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Skic2 Gene Detail
Summary
  • Symbol
    Skic2
  • Name
    SKI2 subunit of superkiller complex
  • Synonyms
    4930534J06Rik, Ski2w, Skiv2l
  • Feature Type
    protein coding gene
  • IDs
    MGI:1099835
    NCBI Gene: 108077
  • Alliance
    genome feature page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:35058202-35069180 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 18.39 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1099835
 protein coding gene Chr17:35058202-35069186 (-)
129S1/SvImJ ENSMUSG00200049873
 protein coding gene Chr17:30760687-30772565 (-)
A/J ENSMUSG00195036274
 protein coding gene Chr17:31660220-31672714 (-)
AKR/J ENSMUSG00220049715
 protein coding gene Chr17:30688808-30701388 (-)
BALB/cJ ENSMUSG00180035566
 protein coding gene Chr17:31030773-31042580 (-)
C3H/HeJ ENSMUSG00175028836
 protein coding gene Chr17:30574919-30587502 (-)
C57BL/6NJ ENSMUSG00215046964
 protein coding gene Chr17:30600172-30612752 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021477
 protein coding gene Chr17:31573996-31584873 (-)
CAST/EiJ ENSTCUG00005040806
 protein coding gene Chr17:31618392-31630976 (-)
CBA/J ENSMUSG00210047691
 protein coding gene Chr17:30397027-30409609 (-)
DBA/2J ENSMUSG00185045781
 protein coding gene Chr17:33049352-33061844 (-)
FVB/NJ ENSMUSG00205041218
 protein coding gene Chr17:30918984-30931270 (-)
JF1/MsJ ENSUMUG00000051325
 protein coding gene Chr17:32301785-32314381 (-)
LP/J ENSMUSG00230054584
 protein coding gene Chr17:34158949-34170827 (-)
NOD/ShiLtJ ENSMUSG00190051078
 protein coding gene Chr17:30519823-30532325 (-)
NZO/HlLtJ ENSMUSG00225053709
 protein coding gene Chr17:36171264-36183835 (-)
PWK/PhJ ENSLUMG00010046883
 protein coding gene Chr17:30136724-30149296 (-)
SPRET/EiJ ENSMSPG00010047817
 protein coding gene Chr17:31323700-31334705 (-)
WSB/EiJ ENSIUOG00005050110
 protein coding gene Chr17:31247575-31260066 (-)



Homology
more
  • Human Ortholog
    SKIC2, SKI2 subunit of superkiller complex
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SKIC2, SKI2 subunit of superkiller complex
  • Synonyms
    170A, DDX13, HLP, SKI2, SKI2W, SKIV2, SKIV2L, SKIV2L1, THES2
  • Links
    NCBI Gene ID: 6499
    UniProt: Q15477

  • Chr Location
    6p21.33; chr6:31959116-31969852 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human SKIC2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    1 phenotype from multigenic genotypes
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a transgenic gene disruption exhibit embryonic lethality at E6.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    34
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    598
  • Tissues
    1
  • cDNA Data
    119
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 108077 NCBI Gene Model | MGI Sequence Detail 10979 C57BL/6J ±  kb
    transcript NM_021337 RefSeq | MGI Sequence Detail 3972 C57BL/6  
    polypeptide Q6NZR5 UniProt | EBI | MGI Sequence Detail 1244 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 120
      Genomic 1
      cDNA 119

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:2147055, MGI:2148488, MGI:2442955, MGI:7382774
    References
    more
    • Summaries
      All 45
      Developmental Gene Expression 1
      Gene Ontology 8
      Phenotypes 13
    • Earliest
      J:43702 Gee S, et al., Cloning of mDEAH9, a putative RNA helicase and mammalian homologue of Saccharomyces cerevisiae splicing factor Prp43. Proc Natl Acad Sci U S A. 1997 Oct 28;94(22):11803-7
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory