Rad51b MGI Mouse Gene Detail - MGI:1099436 - RAD51 paralog B

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Rad51b Gene Detail

Symbol

Rad51b
Name

RAD51 paralog B
Synonyms

mREC2, R51H2, Rad51b, Rad51l1

Feature Type

protein coding gene
IDs

MGI:1099436
NCBI Gene: 19363
Alliance

gene page
Transcription Start Sites

31 TSS

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Sequence Map

Chr12:79344056-79861464 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 12, 35.51 cM
Mapping Data

2 experiments

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SNPs within 2kb

3538 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates	Select Strains
C57BL/6J	MGI_C57BL6J_1099436	protein coding gene	Chr12:79344032-79895034 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0019884	protein coding gene	Chr12:79586991-79813935 (+)
A/J	MGP_AJ_G0019842	protein coding gene	Chr12:76728748-76940219 (+)
AKR/J	MGP_AKRJ_G0019817	protein coding gene	Chr12:78804738-79026298 (+)
BALB/cJ	MGP_BALBcJ_G0019821	protein coding gene	Chr12:76977216-77191988 (+)
C3H/HeJ	MGP_C3HHeJ_G0019627	protein coding gene	Chr12:79281752-79500671 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0020273	protein coding gene	Chr12:81941178-82176894 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017892	protein coding gene	Chr12:73747216-73958287 (+)
CAST/EiJ	MGP_CASTEiJ_G0019177	protein coding gene	Chr12:74119697-74344661 (+)
CBA/J	MGP_CBAJ_G0019598	protein coding gene	Chr12:85121465-85378796 (+)
DBA/2J	MGP_DBA2J_G0019713	protein coding gene	Chr12:76346715-76561369 (+)
FVB/NJ	MGP_FVBNJ_G0019699	protein coding gene	Chr12:75161825-75376427 (+)
LP/J	MGP_LPJ_G0019785	protein coding gene	Chr12:79528222-79755737 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019738	protein coding gene	Chr12:88203524-88435431 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020308	protein coding gene	Chr12:78320567-78542821 (+)
PWK/PhJ	MGP_PWKPhJ_G0018943	protein coding gene	Chr12:70712308-70929772 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0018737	protein coding gene	Chr12:72821869-73034544 (+)
WSB/EiJ	MGP_WSBEiJ_G0019230	protein coding gene	Chr12:78943215-79171984 (+)

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Human Ortholog

RAD51B, RAD51 paralog B

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

RAD51B, RAD51 paralog B
Synonyms

R51H2, RAD51L1, REC2
Links

HGNC:9822

NCBI Gene ID: 5890

neXtProt AC: NX_O15315

UniProt: O15315
Chr Location

14q24.1; chr14:67819779-68730218 (+) GRCh38

MGI Vertebrate Homology

Rad51b stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: RAD51B
Protein SuperFamily

Rad51
Gene Tree

Rad51b

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
1 phenotype from multigenic genotypes
10 phenotype references

Phenotype Overview

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

25
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

20
Targeted

3
Genomic Mutations

1 involving Rad51b
Incidental Mutations

APF
Find Mice (IMSR)

25 strains or lines available

Embryos homozygous for a knock-out allele are severely growth retarded and exhibit complete early embryonic lethality; interestingly, mutant embryos survive and develop further in a Trp53-null background.

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All GO Annotations

28
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

750
Tissues

9
cDNA Data

16
Literature Summary

4

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

ZFIN rad51b

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All Sequences

72
RefSeq

40
UniProt

1
CCDS

CCDS56845.1, CCDS88360.1

Ensembl

ENSMUSG00000059060 (Evidence)
NCBI Gene

19363

Representative Sequences				Length	Strain/Species	Flank
	genomic	ENSMUSG00000059060	Ensembl Gene Model \| MGI Sequence Detail	517409	C57BL/6J	± kb
	transcript	ENSMUST00000171210	Ensembl \| MGI Sequence Detail	1858	Not Applicable
	polypeptide	ENSMUSP00000128357	Ensembl \| MGI Sequence Detail	350	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000013676 DNA repair protein RAD51 homolog 2

(term hierarchy)
InterPro Domains

IPR003593 AAA+ ATPase domain

IPR013632 DNA recombination and repair protein Rad51-like, C-terminal

IPR016467 DNA recombination and repair protein, RecA-like

IPR020588 DNA recombination and repair protein RecA-like, ATP-binding domain

IPR030548 DNA repair protein RAD51 homologue 2

IPR027417 P-loop containing nucleoside triphosphate hydrolase

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All nucleic 20

Genomic 2

cDNA 18

Microarray probesets 4

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MGI:2144860

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Summaries

All 40

Developmental Gene Expression 4

Gene Ontology 6

Phenotypes 10
Earliest

J:41747 Rice MC, et al., Isolation of human and mouse genes based on homology to REC2, a recombinational repair gene from the fungus Ustilago maydis. Proc Natl Acad Sci U S A. 1997 Jul 8;94(14):7417-22
Latest

J:336101 Dickinson K, et al., WT1 regulates expression of DNA repair gene Neil3 during nephrogenesis. Am J Physiol Renal Physiol. 2023 Mar 1;324(3):F245-F255

TSS for Rad51b:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr114093	Chr12:79343211-79343224 (+)	-838 bp
Tssr114094	Chr12:79344085-79344101 (+)	37 bp
Tssr114095	Chr12:79344119-79344151 (+)	79 bp
Tssr114096	Chr12:79350090-79350113 (+)	6,046 bp
Tssr114097	Chr12:79373873-79373905 (+)	29,833 bp
Tssr114098	Chr12:79374013-79374024 (+)	29,963 bp
Tssr114099	Chr12:79382162-79382208 (+)	38,129 bp
Tssr114100	Chr12:79430584-79430605 (+)	86,539 bp
Tssr114101	Chr12:79432918-79432921 (+)	88,864 bp
Tssr3875	Chr12:79437148-79437152 (+)	93,094 bp
Tssr114102	Chr12:79528775-79528778 (+)	184,721 bp
Tssr114103	Chr12:79536917-79536928 (+)	192,867 bp
Tssr114104	Chr12:79579346-79579351 (+)	235,293 bp
Tssr114105	Chr12:79594533-79594551 (+)	250,486 bp
Tssr114106	Chr12:79605818-79605826 (+)	261,766 bp
Tssr114107	Chr12:79606519-79606540 (+)	262,474 bp
Tssr114108	Chr12:79617001-79617006 (+)	272,948 bp
Tssr114109	Chr12:79621822-79621827 (+)	277,769 bp
Tssr3876	Chr12:79658013-79658017 (+)	313,959 bp
Tssr114110	Chr12:79689797-79689801 (+)	345,743 bp
Tssr114111	Chr12:79692586-79692607 (+)	348,541 bp
Tssr114112	Chr12:79710608-79710611 (+)	366,554 bp
Tssr114113	Chr12:79769155-79769166 (+)	425,105 bp
Tssr114114	Chr12:79797260-79797302 (+)	453,225 bp
Tssr3877	Chr12:79805021-79805046 (+)	460,978 bp
Tssr114115	Chr12:79809147-79809162 (+)	465,099 bp
Tssr114116	Chr12:79813632-79813651 (+)	469,586 bp
Tssr114117	Chr12:79813656-79813698 (+)	469,621 bp
Tssr114118	Chr12:79816819-79816833 (+)	472,770 bp
Tssr114119	Chr12:79816858-79816866 (+)	472,806 bp
Tssr114120	Chr12:79817213-79817216 (+)	473,159 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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