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Tbc1d14 Gene Detail
Summary
  • Symbol
    Tbc1d14
  • Name
    TBC1 domain family, member 14
  • Synonyms
    2810413P16Rik, D5Ertd110e, mKIAA1322
  • Feature Type
    protein coding gene
  • IDs
    MGI:1098708
    NCBI Gene: 100855
  • Alliance
    genome feature page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:36647948-36743611 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 19.15 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2141 from dbSNP Build 142
  • Strain Annotations
    27
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1098708
 protein coding gene Chr5:36647948-36750620 (-)
129S1/SvImJ ENSMUSGG00200054740
 protein coding gene Chr5:32117780-32164326 (-)
129S1/SvImJ ENSMUSG00200031506
 protein coding gene Chr5:32176766-32218365 (-)
A/J ENSMUSGG00195055427
 protein coding gene Chr5:31591194-31631414 (-)
A/J ENSMUSG00195029255
 protein coding gene Chr5:31643965-31684603 (-)
AKR/J ENSMUSG00220002149
 protein coding gene Chr5:31670556-31711194 (-)
AKR/J ENSMUSGG00220054501
 protein coding gene Chr5:31617780-31658000 (-)
BALB/cJ ENSMUSG00180022063
 protein coding gene Chr5:31446820-31487455 (-)
BALB/cJ ENSMUSGG00180055430
 protein coding gene Chr5:31394039-31434259 (-)
C3H/HeJ ENSMUSG00175018348
 protein coding gene Chr5:33431067-33471705 (-)
C3H/HeJ ENSMUSGG00175054839
 protein coding gene Chr5:33378294-33418510 (-)
C57BL/6NJ ENSMUSGG00215055223
 protein coding gene Chr5:32115020-32155218 (-)
C57BL/6NJ ENSMUSG00215005104
 protein coding gene Chr5:32167660-32209256 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027159
 protein coding gene Chr5:31428939-31531944 (-)
CAST/EiJ no annotation
CBA/J ENSMUSG00210003496
 protein coding gene Chr5:32395095-32435733 (-)
CBA/J ENSMUSGG00210054943
 protein coding gene Chr5:32342324-32382540 (-)
DBA/2J ENSMUSG00185015312
 protein coding gene Chr5:34262417-34303053 (-)
DBA/2J ENSMUSGG00185057629
 protein coding gene Chr5:34209683-34249889 (-)
FVB/NJ ENSMUSG00205016594
 protein coding gene Chr5:31146482-31187115 (-)
FVB/NJ ENSMUSGG00205054352
 protein coding gene Chr5:31093752-31133957 (-)
JF1/MsJ no annotation
LP/J ENSMUSGG00230055388
 protein coding gene Chr5:38821354-38867898 (-)
LP/J ENSMUSG00230045294
 protein coding gene Chr5:38880337-38921931 (-)
NOD/ShiLtJ ENSMUSG00190003117
 protein coding gene Chr5:31445536-31486158 (-)
NOD/ShiLtJ ENSMUSGG00190054826
 protein coding gene Chr5:31392792-31433012 (-)
NZO/HlLtJ ENSMUSGG00225055430
 protein coding gene Chr5:44024696-44064917 (-)
NZO/HlLtJ ENSMUSG00225016061
 protein coding gene Chr5:44077456-44118072 (-)
PWK/PhJ no annotation
SPRET/EiJ ENSMSPG00010033799
 protein coding gene Chr5:32714113-32818194 (-)
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    TBC1D14, TBC1 domain family member 14
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TBC1D14, TBC1 domain family member 14
  • Links
    NCBI Gene ID: 57533
    UniProt: Q9P2M4

  • Chr Location
    4p16.1; chr4:6909242-7033118 (+)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    29 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    31
  • Chemically induced (ENU)
    2
  • Chemically induced (other)
    2
  • Endonuclease-mediated
    3
  • Gene trapped
    18
  • Radiation induced
    4
  • Spontaneous
    1
  • Targeted
    1
  • Genomic Mutations
    8 involving Tbc1d14
  • Incidental Mutations
    Mutagenetix , APF
  • Find Mice (IMSR)
    35 strains or lines available
Embryos homozygous for an ENU-induced mutation appear arrested at an egg cylinder-like state and show complete embryonic lethality between implantation and placentation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    15
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    616
  • Tissues
    19
  • cDNA Data
    179
  • Literature Summary
    2
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 100855 NCBI Gene Model | MGI Sequence Detail 95664 C57BL/6J ±  kb
transcript NM_001113362 RefSeq | MGI Sequence Detail 4783 ZRU/MplStud  
polypeptide Q8CGA2 UniProt | EBI | MGI Sequence Detail 694 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 181
    cDNA 180
    Primer pair 1

    Microarray probesets 4
Other
Accession IDs
less
MGI:1919674, MGI:2141090, MGI:2141331
References
more
  • Summaries
    All 57
    Developmental Gene Expression 2
    Diseases 1
    Gene Ontology 5
    Phenotypes 29
  • Earliest
    J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
  • Latest
    J:313619 Bedogni F, et al., Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory