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Mfhas1 Gene Detail
Summary
  • Symbol
    Mfhas1
  • Name
    malignant fibrous histiocytoma amplified sequence 1
  • Synonyms
    2310066G09Rik, D8Ertd91e
  • Feature Type
    protein coding gene
  • IDs
    MGI:1098644
    NCBI Gene: 52065
  • Alliance
    genome feature page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:36054952-36146603 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 21.16 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3237 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1098644
 protein coding gene Chr8:36054922-36146603 (+)
129S1/SvImJ ENSMUSG00200007434
 protein coding gene Chr8:31148988-31238833 (+)
A/J ENSMUSG00195005848
 protein coding gene Chr8:31651092-31740949 (+)
AKR/J ENSMUSG00220005663
 protein coding gene Chr8:31413766-31503618 (+)
BALB/cJ ENSMUSG00180003165
 protein coding gene Chr8:31194433-31284287 (+)
C3H/HeJ ENSMUSG00175014042
 protein coding gene Chr8:31356987-31446839 (+)
C57BL/6NJ ENSMUSG00215006588
 protein coding gene Chr8:31124019-31215679 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030980
 protein coding gene Chr8:29798402-29890279 (+)
CAST/EiJ ENSTCUG00005005313
 protein coding gene Chr8:31309603-31401817 (+)
CBA/J ENSMUSG00210012727
 protein coding gene Chr8:31179958-31269804 (+)
DBA/2J ENSMUSG00185002088
 protein coding gene Chr8:37106232-37196073 (+)
FVB/NJ ENSMUSG00205002253
 protein coding gene Chr8:30392559-30482410 (+)
JF1/MsJ ENSUMUG00000007139
 protein coding gene Chr8:38800005-38891661 (+)
LP/J ENSMUSG00230009489
 protein coding gene Chr8:40756352-40846194 (+)
NOD/ShiLtJ ENSMUSG00190015542
 protein coding gene Chr8:31227876-31317709 (+)
NZO/HlLtJ ENSMUSG00225014259
 protein coding gene Chr8:44353009-44442344 (+)
PWK/PhJ ENSLUMG00010012679
 protein coding gene Chr8:31024503-31116817 (+)
SPRET/EiJ ENSMSPG00010004457
 protein coding gene Chr8:31744002-31835667 (+)
WSB/EiJ ENSIUOG00005005286
 protein coding gene Chr8:31981458-32073875 (+)



Homology
more
  • Human Ortholog
    MFHAS1, multifunctional ROCO family signaling regulator 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MFHAS1, multifunctional ROCO family signaling regulator 1
  • Synonyms
    LRRC65, MASL1, ROCO4
  • Links
    NCBI Gene ID: 9258
    UniProt: Q9Y4C4

  • Chr Location
    8p23.1; chr8:8783354-8893630 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    3 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    66
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    702
  • Tissues
    10
  • cDNA Data
    59
  • Literature Summary
    1
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000070056 Ensembl Gene Model | MGI Sequence Detail 91652 C57BL/6J ±  kb
transcript ENSMUST00000037666 Ensembl | MGI Sequence Detail 6408 Not Applicable  
polypeptide ENSMUSP00000044135 Ensembl | MGI Sequence Detail 1048 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 60
    cDNA 59
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
less
MGI:1919190
References
more
  • Summaries
    All 33
    Developmental Gene Expression 1
    Gene Ontology 8
    Phenotypes 3
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:262346 Zhong J, et al., MFHAS1 Is Associated with Sepsis and Stimulates TLR2/NF-kappaB Signaling Pathway Following Negative Regulation. PLoS One. 2015;10(11):e0143662
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory