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Ap1s1 Gene Detail
Summary
  • Symbol
    Ap1s1
  • Name
    adaptor protein complex AP-1, sigma 1
  • Synonyms
    AP19
  • Feature Type
    protein coding gene
  • IDs
    MGI:1098244
    NCBI Gene: 11769
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:137063847-137074962 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 76.13 cM, cytoband G1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    38 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1098244
 protein coding gene Chr5:137063847-137074989 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030215
 protein coding gene Chr5:141754864-141765966 (-)
A/J MGP_AJ_G0030183
 protein coding gene Chr5:135608092-135619194 (-)
AKR/J MGP_AKRJ_G0030116
 protein coding gene Chr5:139999686-140010736 (-)
BALB/cJ MGP_BALBcJ_G0030193
 protein coding gene Chr5:136966932-136978033 (-)
C3H/HeJ MGP_C3HHeJ_G0029909
 protein coding gene Chr5:140626438-140637538 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030645
 protein coding gene Chr5:147023434-147034576 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027865
 protein coding gene Chr5:129877526-129888671 (-)
CAST/EiJ MGP_CASTEiJ_G0029319
 protein coding gene Chr5:140040177-140051284 (-)
CBA/J MGP_CBAJ_G0029879
 protein coding gene Chr5:152770912-152782014 (-)
DBA/2J MGP_DBA2J_G0030030
 protein coding gene Chr5:135504113-135515216 (-)
FVB/NJ MGP_FVBNJ_G0029985
 protein coding gene Chr5:134684303-134695405 (-)
LP/J MGP_LPJ_G0030119
 protein coding gene Chr5:142183087-142194342 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030017
 protein coding gene Chr5:155667407-155678509 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030686
 protein coding gene Chr5:139832811-139843912 (-)
PWK/PhJ MGP_PWKPhJ_G0029032
 protein coding gene Chr5:134594013-134605283 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028868
 protein coding gene Chr5:137417780-137433241 (-)
WSB/EiJ MGP_WSBEiJ_G0029392
 protein coding gene Chr5:140575477-140586490 (-)



Homology
more
  • Human Ortholog
    AP1S1, adaptor related protein complex 1 subunit sigma 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    AP1S1, adaptor related protein complex 1 subunit sigma 1
  • Synonyms
    AP19, CLAPS1, EKV3, MEDNIK, SIGMA1A
  • Links
    NCBI Gene ID: 1174
    neXtProt AC: NX_P61966
    UniProt: P61966

  • Chr Location
    7q22.1; chr7:101154456-101161596 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human AP1S1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    104 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    19
  • Endonuclease-mediated
    2
  • Gene trapped
    12
  • Targeted
    4
  • Transgenic
    1
  • Genomic Mutations
    1 involving Ap1s1
  • Incidental Mutations
    APF
  • Find Mice (IMSR)
    17 strains or lines available
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    21
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    135
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 11769 NCBI Gene Model | MGI Sequence Detail 11116 C57BL/6J ±  kb
transcript NM_001420722 RefSeq | MGI Sequence Detail 1822 C57BL/6  
polypeptide P61967 UniProt | EBI | MGI Sequence Detail 158 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 135
    cDNA 135

    Microarray probesets 3
References
more
  • Summaries
    All 139
    Gene Ontology 13
    Phenotypes 104
  • Earliest
    J:43399 Kirchhausen T, et al., AP17 and AP19, the mammalian small chains of the clathrin-associated protein complexes show homology to Yap17p, their putative homolog in yeast. J Biol Chem. 1991 Jun 15;266(17):11153-7
  • Latest
    J:343796 Kotov DI, et al., Early cellular mechanisms of type I interferon-driven susceptibility to tuberculosis. Cell. 2023 Nov 18;
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/09/2024
MGI 6.23 		The Jackson Laboratory