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Kif14 Gene Detail
Summary
  • Symbol
    Kif14
  • Name
    kinesin family member 14
  • Synonyms
    D1Ertd367e, N-3 kinesin
  • Feature Type
    protein coding gene
  • IDs
    MGI:1098226
    NCBI Gene: 381293
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:136394081-136459249 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 1, 59.80 cM, cytoband F
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    834 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1098226
protein coding gene Chr1:136394044-136483676 (+)
129S1/SvImJ MGP_129S1SvImJ_G0016542
protein coding gene Chr1:140298669-140369748 (+)
A/J MGP_AJ_G0016525
protein coding gene Chr1:134974699-135041220 (+)
AKR/J MGP_AKRJ_G0016490
protein coding gene Chr1:138984715-139052936 (+)
BALB/cJ MGP_BALBcJ_G0016485
protein coding gene Chr1:135305617-135370509 (+)
C3H/HeJ MGP_C3HHeJ_G0016311
protein coding gene Chr1:139090654-139158802 (+)
C57BL/6NJ MGP_C57BL6NJ_G0016946
protein coding gene Chr1:145309006-145377534 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014657
protein coding gene Chr1:128089601-128156282 (+)
CAST/EiJ MGP_CASTEiJ_G0015891
protein coding gene Chr1:138198316-138268859 (+)
CBA/J MGP_CBAJ_G0016284
protein coding gene Chr1:150348070-150417694 (+)
DBA/2J MGP_DBA2J_G0016390
protein coding gene Chr1:133968830-134038248 (+)
FVB/NJ MGP_FVBNJ_G0016389
protein coding gene Chr1:132617410-132683515 (+)
LP/J MGP_LPJ_G0016461
protein coding gene Chr1:141511640-141579799 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016414
protein coding gene Chr1:155978252-156056342 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0016982
protein coding gene Chr1:138752779-138821526 (+)
PWK/PhJ MGP_PWKPhJ_G0015677
protein coding gene Chr1:133020098-133088623 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015464
protein coding gene Chr1:137743726-137815789 (+)
WSB/EiJ MGP_WSBEiJ_G0015954
protein coding gene Chr1:138794425-138865624 (+)



Homology
more
  • Human Ortholog
    KIF14, kinesin family member 14
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KIF14, kinesin family member 14
  • Synonyms
    MCPH20, MKS12
  • Links
    NCBI Gene ID: 9928
    neXtProt AC: NX_Q15058
    UniProt: Q15058

  • Chr Location
    1q32.1; chr1:200551497-200620751 (-)  GRCh38

Human Diseases
more
  • Diseases
    2 with human KIF14 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    32 phenotypes from 2 alleles in 2 genetic backgrounds
    2 phenotypes from multigenic genotypes
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a spontaneous mutation or targeted allele exhibit severe brain malformations, neurological defects and hypomyelination.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000041498 Ensembl Gene Model | MGI Sequence Detail 65169 C57BL/6J ±  kb
    transcript ENSMUST00000189413 Ensembl | MGI Sequence Detail 8943 Not Applicable  
    polypeptide ENSMUSP00000139698 Ensembl | MGI Sequence Detail 1674 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 22
      Genomic 1
      cDNA 19
      Primer pair 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1196255
    References
    more
    • Summaries
      All 41
      Developmental Gene Expression 3
      Gene Ontology 7
      Phenotypes 12
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:269628 Sishtla K, et al., Observations on spontaneous tumor formation in mice overexpressing mitotic kinesin Kif14. Sci Rep. 2018 Nov 1;8(1):16152

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    03/12/2024
    MGI 6.23
    The Jackson Laboratory