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Degs1 Gene Detail
Summary
  • Symbol
    Degs1
  • Name
    delta 4-desaturase, sphingolipid 1
  • Synonyms
    Des1, Mdes
  • Feature Type
    protein coding gene
  • IDs
    MGI:1097711
    NCBI Gene: 13244
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:182103529-182110366 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 84.93 cM, cytoband H5
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    268 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1097711
 protein coding gene Chr1:182103337-182110369 (-)
129S1/SvImJ ENSMUSG00200021883
 protein coding gene Chr1:179863956-179870988 (-)
A/J ENSMUSG00195039061
 protein coding gene Chr1:179456302-179463341 (-)
AKR/J ENSMUSG00220020269
 protein coding gene Chr1:178694402-178701446 (-)
BALB/cJ ENSMUSG00180036081
 protein coding gene Chr1:179515294-179522326 (-)
C3H/HeJ ENSMUSG00175034644
 protein coding gene Chr1:179690981-179698013 (-)
C57BL/6NJ ENSMUSG00215011902
 protein coding gene Chr1:178916722-178923754 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014999
 protein coding gene Chr1:172121784-172129102 (-)
CAST/EiJ ENSTCUG00005041532
 protein coding gene Chr1:177434268-177441314 (-)
CBA/J ENSMUSG00210018293
 protein coding gene Chr1:179334236-179341280 (-)
DBA/2J ENSMUSG00185033734
 protein coding gene Chr1:183953649-183960693 (-)
FVB/NJ ENSMUSG00205032599
 protein coding gene Chr1:178384834-178391879 (-)
JF1/MsJ ENSUMUG00000004257
 protein coding gene Chr1:182956418-182963444 (-)
LP/J ENSMUSG00230019370
 protein coding gene Chr1:183523220-183530252 (-)
NOD/ShiLtJ ENSMUSG00190025776
 protein coding gene Chr1:179372796-179379835 (-)
NZO/HlLtJ ENSMUSG00225010526
 protein coding gene Chr1:187264940-187271954 (-)
PWK/PhJ ENSLUMG00010016138
 protein coding gene Chr1:178206404-178213455 (-)
SPRET/EiJ ENSMSPG00010032067
 protein coding gene Chr1:181688173-181693993 (-)
WSB/EiJ ENSIUOG00005010879
 protein coding gene Chr1:178555760-178562792 (-)



Homology
more
  • Human Ortholog
    DEGS1, delta 4-desaturase, sphingolipid 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DEGS1, delta 4-desaturase, sphingolipid 1
  • Synonyms
    DEGS, DEGS-1, Des-1, DES1, FADS7, HLD18, MIG15, MLD
  • Links
    NCBI Gene ID: 8560
    UniProt: O15121

  • Chr Location
    1q42.11; chr1:224175756-224193441 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human DEGS1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    25 phenotypes from 2 alleles in 2 genetic backgrounds
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit premature death, decreased to absent ceramide levels, decreased body weight, scaly skin, sparse hair, tremors, hematological and blood chemistry abnormalities, decreased bone mineral content and density and decreased liver function.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    31
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    716
  • Tissues
    103
  • cDNA Data
    145
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 13244 NCBI Gene Model | MGI Sequence Detail 6838 C57BL/6J ±  kb
    transcript NM_007853 RefSeq | MGI Sequence Detail 1853 C57BL/6  
    polypeptide O09005 UniProt | EBI | MGI Sequence Detail 323 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 146
      cDNA 145
      Primer pair 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2138108
    References
    more
    • Summaries
      All 63
      Developmental Gene Expression 6
      Gene Ontology 11
      Phenotypes 21
    • Earliest
      J:41881 Endo K, et al., Mdes, a mouse homolog of the Drosophila degenerative spermatocyte gene is expressed during mouse spermatogenesis. Dev Growth Differ. 1997 Jun;39(3):399-403
    • Latest
      J:389049 Nicholson RJ, et al., Therapeutic remodeling of the ceramide backbone prevents kidney injury. Cell Metab. 2025 Nov 12;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory