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Opn1mw Gene Detail
Summary
  • Symbol
    Opn1mw
  • Name
    opsin 1 (cone pigments), medium-wave-sensitive (color blindness, deutan)
  • Synonyms
    Gcp, green long wavelength sensitive cone opsin, green LWS cone opsin, Green opsin, G/R opsin, Midwavelength sensitive opsin, ML-opsin, M opsin, MWS opsin, Opn1lw, R/G opsin, Rsvp
  • Feature Type
    protein coding gene
  • IDs
    MGI:1097692
    NCBI Gene: 14539
  • Alliance
    genome feature page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:73171072-73194362 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, Syntenic
  • Mapping Data
    44 experiments
Strain
Comparison
more
  • SNPs within 2kb
    467 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    7
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1097692
 protein coding gene ChrX:73171070-73194366 (+)
129S1/SvImJ ENSMUSG00200042734
 protein coding gene ChrX:55231885-55255173 (+)
A/J ENSMUSG00195034337
 protein coding gene ChrX:58907946-58931229 (+)
AKR/J ENSMUSG00220042998
 protein coding gene ChrX:54210261-54233549 (+)
BALB/cJ ENSMUSG00180048658
 protein coding gene ChrX:55488689-55511966 (+)
C3H/HeJ ENSMUSG00175032515
 protein coding gene ChrX:59072318-59095592 (+)
C57BL/6NJ ENSMUSG00215039058
 protein coding gene ChrX:55572320-55595622 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0033171
 protein coding gene ChrX:69135539-69194809 (+)
CAST/EiJ ENSTCUG00005037548
 protein coding gene ChrX:56989634-57012945 (+)
CBA/J ENSMUSG00210040382
 protein coding gene ChrX:55752988-55776269 (+)
DBA/2J ENSMUSG00185033624
 protein coding gene ChrX:68174610-68197902 (+)
FVB/NJ ENSMUSG00205027983
 protein coding gene ChrX:55054001-55077278 (+)
JF1/MsJ ENSUMUG00000029844
 protein coding gene ChrX:88914704-88936647 (+)
LP/J ENSMUSG00230032348
 protein coding gene ChrX:74754019-74777301 (+)
NOD/ShiLtJ ENSMUSG00190032416
 protein coding gene ChrX:54992953-55016230 (+)
NZO/HlLtJ ENSMUSG00225047464
 protein coding gene ChrX:79958415-79981697 (+)
PWK/PhJ ENSLUMG00010040856
 protein coding gene ChrX:54736019-54757946 (+)
SPRET/EiJ ENSMSPG00010032376
 protein coding gene ChrX:57820489-57844123 (+)
WSB/EiJ ENSIUOG00005049031
 protein coding gene ChrX:55820368-55843637 (+)



Homology
more
  • Human Ortholog
    OPN1LW, opsin 1, long wave sensitive
  • Vertebrate Orthologs
    7
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    OPN1LW, opsin 1, long wave sensitive
  • Synonyms
    CBBM, CBP, COD5, RCP, ROP
  • Links
    NCBI Gene ID: 5956
    UniProt: P04000

  • Chr Location
    Xq28; chrX:154144243-154159032 (+)  GRCh38
  • Human Ortholog
    OPN1MW, opsin 1, medium wave sensitive
  • Synonyms
    CBBM, CBD, COD5, GCP, GOP, OPN1MW1
  • Links
    NCBI Gene ID: 2652
    UniProt: P04001

  • Chr Location
    Xq28; chrX:154182596-154196861 (+)  GRCh38
  • Human Ortholog
    OPN1MW2, opsin 1, medium wave sensitive 2
  • Synonyms
    GOP
  • Links
    NCBI Gene ID: 728458
    UniProt: P0DN77

  • Chr Location
    Xq28; chrX:154219756-154233286 (+)  GRCh38
  • Human Ortholog
    OPN1MW3, opsin 1, medium wave sensitive 3
  • Synonyms
    GCP, GOP
  • Links
    NCBI Gene ID: 101060233
    UniProt: P0DN78

  • Chr Location
    chrX:154257582-154271090 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Opn1mw mouse models; 3 with human OPN1LW,OPN1MW associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    2 phenotypes from multigenic genotypes
    30 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
A knock-in allele encoding a derivative of the human red cone pigment results in hemizygous male and homozygous female mice with a ~45-nm red shift in retinal sensitivity; heterozygous females show significant changes in the chromatic sensitivities of retinal ganglion cells.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    32
  • GO References
    17
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    815
  • Tissues
    21
  • cDNA Data
    17
  • Literature Summary
    76
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 14539 NCBI Gene Model | MGI Sequence Detail 23291 C57BL/6J ±  kb
    transcript NM_008106 RefSeq | MGI Sequence Detail 1221 ZRU/MplStud  
    polypeptide O35599 UniProt | EBI | MGI Sequence Detail 359 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 41
      Genomic 8
      cDNA 19
      Primer pair 12
      Other 2
      Antibodies 9

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGD-MRK-14245, MGI:98202
    References
    more
    • Summaries
      All 184
      Developmental Gene Expression 76
      Diseases 1
      Gene Ontology 17
      Phenotypes 30
    • Earliest
      J:24447 Nathans J, et al., Molecular genetics of human color vision: the genes encoding blue, green, and red pigments. Science. 1986 Apr 11;232(4747):193-202
    • Latest
      J:386380 Krueger MR, et al., Roles of sonic hedgehog signaling in retinal patterning and neurogenesis during mammalian eye development. Development. 2026 May 1;153(9):dev205143
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory