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Cx3cl1 Gene Detail
Summary
  • Symbol
    Cx3cl1
  • Name
    C-X3-C motif chemokine ligand 1
  • Synonyms
    CX3C, D8Bwg0439e, fractalkine, neurotactin, Scyd1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1097153
    NCBI Gene: 20312
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:95498808-95509055 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 46.79 cM
  • Mapping Data
    8 experiments
Strain
Comparison
more
  • SNPs within 2kb
    64 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1097153
 protein coding gene Chr8:95498637-95509055 (+)
129S1/SvImJ MGP_129S1SvImJ_G0033968
 protein coding gene Chr8:96209147-96219551 (+)
A/J MGP_AJ_G0033951
 protein coding gene Chr8:92464297-92474702 (+)
AKR/J MGP_AKRJ_G0033877
 protein coding gene Chr8:94982653-94993059 (+)
BALB/cJ MGP_BALBcJ_G0033943
 protein coding gene Chr8:92544755-92555161 (+)
C3H/HeJ MGP_C3HHeJ_G0033653
 protein coding gene Chr8:95693909-95704313 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034464
 protein coding gene Chr8:99711181-99723243 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031405
 protein coding gene Chr8:86269144-86279607 (+)
CAST/EiJ MGP_CASTEiJ_G0032985
 protein coding gene Chr8:95299033-95309394 (+)
CBA/J MGP_CBAJ_G0033629
 protein coding gene Chr8:103006750-103017156 (+)
DBA/2J MGP_DBA2J_G0033783
 protein coding gene Chr8:91922470-91932876 (+)
FVB/NJ MGP_FVBNJ_G0033730
 protein coding gene Chr8:90890431-90900837 (+)
LP/J MGP_LPJ_G0033875
 protein coding gene Chr8:96358834-96369238 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033772
 protein coding gene Chr8:105304284-105314691 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034482
 protein coding gene Chr8:95149623-95160027 (+)
PWK/PhJ MGP_PWKPhJ_G0032687
 protein coding gene Chr8:91310717-91321212 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032524
 protein coding gene Chr8:93985534-93995935 (+)
WSB/EiJ MGP_WSBEiJ_G0033097
 protein coding gene Chr8:95680525-95690933 (+)



Homology
more
  • Human Ortholog
    CX3CL1, C-X3-C motif chemokine ligand 1
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CX3CL1, C-X3-C motif chemokine ligand 1
  • Synonyms
    ABCD-3, C3Xkine, CXC3, CXC3C, fractalkine, neurotactin, NTN, NTT, SCYD1
  • Links
    NCBI Gene ID: 6376
    neXtProt AC: NX_P78423
    UniProt: P78423

  • Chr Location
    16q21; chr16:57372477-57385044 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with human CX3CL1 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    13 phenotypes from 4 alleles in 6 genetic backgrounds
    6 phenotypes from multigenic genotypes
    28 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele show a specific reduction in Gr1(low) monocyte levels, and increased neuronal cell loss in a neurotoxin (MPTP)-induced model of Parkinson disease. Mice homozygous for a different knock-out allele are less susceptible to cerebral ischemia-reperfusion injury.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    109
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    921
  • Tissues
    70
  • cDNA Data
    90
  • Literature Summary
    10
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 20312 NCBI Gene Model | MGI Sequence Detail 10248 C57BL/6J ±  kb
transcript NM_009142 RefSeq | MGI Sequence Detail 3144 ZRU/MplStud  
polypeptide O35188 UniProt | EBI | MGI Sequence Detail 395 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 94
    cDNA 91
    Primer pair 3

    Microarray probesets 5
Other
Accession IDs
less
MGD-MRK-35756, MGI:107291, MGI:1930149, MGI:2142630
References
more
  • Summaries
    All 132
    Developmental Gene Expression 10
    Gene Ontology 14
    Phenotypes 28
  • Earliest
    J:40832 Pan Y, et al., Neurotactin, a membrane-anchored chemokine upregulated in brain inflammation. Nature. 1997 Jun 5;387(6633):611-7
  • Latest
    J:343446 Chen HJ, et al., Fetal CCL2 signaling mediates offspring social behavior and recapitulates effects of prenatal stress. Brain Behav Immun. 2024 Jan;115:308-318
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/09/2024
MGI 6.23 		The Jackson Laboratory