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Il4i1 Gene Detail
Summary
  • Symbol
    Il4i1
  • Name
    interleukin 4 induced 1
  • Synonyms
    Fig1, Fig1-ps, H-4, H4, H-46, H46
  • Feature Type
    protein coding gene
  • IDs
    MGI:109552
    NCBI Gene: 14204
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:44485712-44490233 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 28.93 cM
  • Mapping Data
    9 experiments
Strain
Comparison
more
  • SNPs within 2kb
    148 from dbSNP Build 142
  • Strain Annotations
    15
  • PCR
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109552
 protein coding gene Chr7:44465811-44490233 (+)
129S1/SvImJ ENSMUSG00200027718
 protein coding gene Chr7:32061589-32086778 (+)
A/J ENSMUSG00195037240
 protein coding gene Chr7:36089656-36114845 (+)
AKR/J no annotation
BALB/cJ ENSMUSG00180036131
 protein coding gene Chr7:32965049-32990238 (+)
C3H/HeJ ENSMUSG00175030918
 protein coding gene Chr7:33497519-33522708 (+)
C57BL/6NJ no annotation
CAROLI/EiJ MGP_CAROLIEiJ_G0029676
 protein coding gene Chr7:46750286-46774746 (+)
CAST/EiJ ENSTCUG00005046931
 protein coding gene Chr7:36474694-36501236 (+)
CBA/J ENSMUSG00210048140
 protein coding gene Chr7:33868884-33894073 (+)
DBA/2J ENSMUSG00185045130
 protein coding gene Chr7:37741515-37766704 (+)
FVB/NJ no annotation
JF1/MsJ ENSUMUG00000017092
 protein coding gene Chr7:42229927-42254958 (+)
LP/J ENSMUSG00230051472
 protein coding gene Chr7:43170977-43195651 (+)
NOD/ShiLtJ no annotation
NZO/HlLtJ ENSMUSG00225014107
 protein coding gene Chr7:41379563-41404236 (+)
PWK/PhJ ENSLUMG00010038844
 protein coding gene Chr7:32698411-32722507 (+)
SPRET/EiJ ENSMSPG00010040827
 protein coding gene Chr7:32490061-32499332 (+)
WSB/EiJ ENSIUOG00005022676
 protein coding gene Chr7:34285487-34310588 (+)



Homology
more
  • Human Ortholog
    IL4I1, interleukin 4 induced 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    IL4I1, interleukin 4 induced 1
  • Synonyms
    FIG1, hIL4I1, LAAO, LAO
  • Links
    NCBI Gene ID: 259307
    UniProt: Q96RQ9

  • Chr Location
    19q13.33; chr19:49889654-49929539 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 2 alleles in 2 genetic backgrounds
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in no obvious phenotype.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    47
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • cDNA Data
    28
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 14204 NCBI Gene Model | MGI Sequence Detail 4522 C57BL/6J ±  kb
    transcript NM_010215 RefSeq | MGI Sequence Detail 2059 ZRU/MplStud  
    polypeptide O09046 UniProt | EBI | MGI Sequence Detail 630 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 32
      Genomic 1
      cDNA 30
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-10460, MGD-MRK-10467, MGD-MRK-10589, MGD-MRK-39551, MGI:892974, MGI:95993
    References
    more
    • Summaries
      All 67
      Gene Ontology 13
      Phenotypes 21
    • Earliest
      J:121 SNELL GD, et al., Histocompatibility genes of mice. III. H-1 and H-4, two histocompatibility loci in the first linkage group. Immunology. 1961 Oct;4:366-79
    • Latest
      J:386367 Fhaikrue I, et al., l-amino acid oxidases Lao1 and Il4i1 are major determinants of early intestinal transcriptional responses to DSS-induced stress. Biochem Biophys Res Commun. 2026 Apr 24;820:153841
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory