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Tnnt3 Gene Detail
Summary
  • Symbol
    Tnnt3
  • Name
    troponin T3, skeletal, fast
  • Synonyms
    fTnT, skeletal muscle fast-twitch TnT
  • Feature Type
    protein coding gene
  • IDs
    MGI:109550
    NCBI Gene: 21957
  • Alliance
    genome feature page
  • Transcription Start Sites
    16 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:142052573-142069746 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 87.94 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    269 from dbSNP Build 142
  • Strain Annotations
    14
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109550
 protein coding gene Chr7:142052530-142069746 (+)
129S1/SvImJ ENSMUSG00200045423
 protein coding gene Chr7:128618946-128636120 (+)
A/J ENSMUSG00195038016
 protein coding gene Chr7:133101006-133118180 (+)
AKR/J ENSMUSG00220034081
 protein coding gene Chr7:126583229-126600401 (+)
BALB/cJ ENSMUSG00180034189
 protein coding gene Chr7:129788757-129809599 (+)
C3H/HeJ ENSMUSG00175033980
 protein coding gene Chr7:130521932-130539104 (+)
C57BL/6NJ ENSMUSG00215045219
 protein coding gene Chr7:129788269-129805445 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030726
 protein coding gene Chr7:144700440-144717308 (+)
CAST/EiJ no annotation
CBA/J ENSMUSG00210026565
 protein coding gene Chr7:130279853-130297026 (+)
DBA/2J ENSMUSG00185014971
 protein coding gene Chr7:134558436-134575608 (+)
FVB/NJ ENSMUSG00205041116
 protein coding gene Chr7:130200561-130217733 (+)
JF1/MsJ no annotation
LP/J ENSMUSG00230041417
 protein coding gene Chr7:140721770-140738944 (+)
NOD/ShiLtJ ENSMUSG00190018526
 protein coding gene Chr7:130387332-130404504 (+)
NZO/HlLtJ ENSMUSG00225051122
 protein coding gene Chr7:138930700-138947871 (+)
PWK/PhJ no annotation
SPRET/EiJ no annotation
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    TNNT3, troponin T3, fast skeletal type
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TNNT3, troponin T3, fast skeletal type
  • Synonyms
    beta-TnTF, DA2B2, TNTF
  • Links
    NCBI Gene ID: 7140
    UniProt: P45378

  • Chr Location
    11p15.5; chr11:1919456-1938711 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with human TNNT3 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 1 allele in 1 genetic background
    1 phenotype from multigenic genotypes
    4 images
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit neonatal lethality, decreased fetal weight, liver and kidney hemorrhage and thin diaphragm. Mice heterozygous for this allele exhibit growth retardation with mild skeleton defects.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    21
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    862
  • Tissues
    96
  • cDNA Data
    97
  • Literature Summary
    37
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000061723 Ensembl Gene Model | MGI Sequence Detail 17174 C57BL/6J ±  kb
    transcript ENSMUST00000179658 Ensembl | MGI Sequence Detail 1079 Not Applicable  
    polypeptide ENSMUSP00000136278 Ensembl | MGI Sequence Detail 272 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 117
      Genomic 7
      cDNA 97
      Primer pair 12
      Other 1
      Antibodies 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-39549
    References
    more
    • Summaries
      All 73
      Developmental Gene Expression 37
      Gene Ontology 4
      Phenotypes 6
    • Earliest
      J:39609 Koch A, et al., cDNA cloning and chromosomal mapping of mouse fast skeletal muscle troponin T. Mamm Genome. 1997 May;8(5):346-8
    • Latest
      J:304923 Doll CF, et al., Gestational intermittent hyperoxia rescues murine genetic congenital heart disease in part. Sci Rep. 2021 Mar 23;11(1):6608
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/15/2026
    MGI 6.29     		The Jackson Laboratory