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Unc5c Gene Detail
Summary
  • Symbol
    Unc5c
  • Name
    unc-5 netrin receptor C
  • Synonyms
    B130051O18Rik, Unc5h3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1095412
    NCBI Gene: 22253
  • Alliance
    gene page
  • Transcription Start Sites
    18 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:141171360-141540685 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 65.57 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    4450 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1095412
 protein coding gene Chr3:141170977-141540685 (+)
129S1/SvImJ MGP_129S1SvImJ_G0027938
 protein coding gene Chr3:144616922-144984695 (+)
A/J MGP_AJ_G0027895
 protein coding gene Chr3:139499204-139863732 (+)
AKR/J MGP_AKRJ_G0027861
 protein coding gene Chr3:143187683-143554073 (+)
BALB/cJ MGP_BALBcJ_G0027907
 protein coding gene Chr3:139297886-139668601 (+)
C3H/HeJ MGP_C3HHeJ_G0027637
 protein coding gene Chr3:143531117-143909925 (+)
C57BL/6NJ MGP_C57BL6NJ_G0028351
 protein coding gene Chr3:149676259-150054134 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025689
 protein coding gene Chr3:134747385-135099287 (+)
CAST/EiJ MGP_CASTEiJ_G0027093
 protein coding gene Chr3:143415607-143800388 (+)
CBA/J MGP_CBAJ_G0027614
 protein coding gene Chr3:154803155-155199775 (+)
DBA/2J MGP_DBA2J_G0027753
 protein coding gene Chr3:138605987-138963336 (+)
FVB/NJ MGP_FVBNJ_G0027720
 protein coding gene Chr3:136055446-136415291 (+)
LP/J MGP_LPJ_G0027863
 protein coding gene Chr3:146062671-146437937 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0027752
 protein coding gene Chr3:163111584-163523434 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0028409
 protein coding gene Chr3:142797304-143162832 (+)
PWK/PhJ MGP_PWKPhJ_G0026817
 protein coding gene Chr3:138415443-138779058 (+)
SPRET/EiJ MGP_SPRETEiJ_G0026644
 protein coding gene Chr3:140879152-141250447 (+)
WSB/EiJ MGP_WSBEiJ_G0027172
 protein coding gene Chr3:143660675-144032342 (+)



Homology
more
  • Human Ortholog
    UNC5C, unc-5 netrin receptor C
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    UNC5C, unc-5 netrin receptor C
  • Synonyms
    UNC5H3
  • Links
    NCBI Gene ID: 8633
    neXtProt AC: NX_O95185
    UniProt: O95185

  • Chr Location
    4q22.3; chr4:95162504-95549206 (-)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    30 phenotypes from 3 alleles in 4 genetic backgrounds
    28 phenotypes from multigenic genotypes
    42 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mutants exhibit ataxia, and reduced size early in life. Mutants exhibit cerebellar defects including reduced size and ectopic cerebellar cells in the midbrain.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    38
  • GO References
    16
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1176
  • Tissues
    214
  • cDNA Data
    53
  • Literature Summary
    62
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 22253 NCBI Gene Model | MGI Sequence Detail 369326 C57BL/6J ±  kb
    transcript NM_001293561 RefSeq | MGI Sequence Detail 9320 ZRU/MplStud  
    polypeptide O08747 UniProt | EBI | MGI Sequence Detail 931 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 69
      Genomic 1
      cDNA 57
      Primer pair 8
      Other 3

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-13803, MGI:2139620, MGI:2442491, MGI:97881
    References
    more
    • Summaries
      All 121
      Developmental Gene Expression 62
      Diseases 1
      Gene Ontology 16
      Phenotypes 42
    • Earliest
      J:28673 Boyer BB, et al., The mitochondrial uncoupling protein gene in brown fat: correlation between DNase I hypersensitivity and expression in transgenic mice. Mol Cell Biol. 1991 Aug;11(8):4147-56
    • Latest
      J:343095 Honeycutt SE, et al., Netrin 1 directs vascular patterning and maturity in the developing kidney. Development. 2023 Nov 15;150(22)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory