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Dpf2 Gene Detail
Summary
  • Symbol
    Dpf2
  • Name
    double PHD fingers 2
  • Synonyms
    2210010M07Rik, Baf45d, Req, requiem, ubi-d4
  • Feature Type
    protein coding gene
  • IDs
    MGI:109529
    NCBI Gene: 19708
  • Alliance
    genome feature page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:5946544-5962899 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 4.34 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    409 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109529
 protein coding gene Chr19:5946544-5963038 (-)
129S1/SvImJ ENSMUSG00200045066
 protein coding gene Chr19:2708961-2725316 (-)
A/J ENSMUSG00195048664
 protein coding gene Chr19:3104258-3120611 (-)
AKR/J ENSMUSG00220043587
 protein coding gene Chr19:2877394-2893748 (-)
BALB/cJ ENSMUSG00180040796
 protein coding gene Chr19:3478971-3495325 (-)
C3H/HeJ ENSMUSG00175011002
 protein coding gene Chr19:2729161-2745514 (-)
C57BL/6NJ ENSMUSG00215043428
 protein coding gene Chr19:2947269-2963624 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022575
 protein coding gene Chr19:2649171-2664757 (-)
CAST/EiJ ENSTCUG00005039919
 protein coding gene Chr19:2865824-2881799 (-)
CBA/J ENSMUSG00210033782
 protein coding gene Chr19:2731934-2748288 (-)
DBA/2J ENSMUSG00185042145
 protein coding gene Chr19:3108428-3124781 (-)
FVB/NJ ENSMUSG00205045549
 protein coding gene Chr19:3114656-3130605 (-)
JF1/MsJ ENSUMUG00000047496
 protein coding gene Chr19:3083684-3099626 (-)
LP/J ENSMUSG00230052823
 protein coding gene Chr19:4015851-4032206 (-)
NOD/ShiLtJ ENSMUSG00190026177
 protein coding gene Chr19:2638760-2655113 (-)
NZO/HlLtJ ENSMUSG00225024896
 protein coding gene Chr19:7724662-7741017 (-)
PWK/PhJ ENSLUMG00010005105
 protein coding gene Chr19:2848963-2864906 (-)
SPRET/EiJ ENSMSPG00010044428
 protein coding gene Chr19:2837212-2854253 (-)
WSB/EiJ ENSIUOG00005038154
 protein coding gene Chr19:2752140-2768493 (-)



Homology
more
  • Human Ortholog
    DPF2, double PHD fingers 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DPF2, double PHD fingers 2
  • Synonyms
    CSS7, REQ, SMARCG2, ubi-d4, UBID4
  • Links
    NCBI Gene ID: 5977
    UniProt: Q92785

  • Chr Location
    11q13.1; chr11:65333821-65354262 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human DPF2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 2 alleles in 2 genetic backgrounds
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a floxed allele are viable and fertile.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    36
  • GO References
    15
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    885
  • Tissues
    265
  • cDNA Data
    27
  • Literature Summary
    16
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 19708 NCBI Gene Model | MGI Sequence Detail 16356 C57BL/6J ±  kb
    transcript NM_001291078 RefSeq | MGI Sequence Detail 3356 ZRU/MplStud  
    polypeptide Q61103 UniProt | EBI | MGI Sequence Detail 391 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 35
      cDNA 28
      Primer pair 4
      Other 3
      Antibodies 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-39528, MGI:1925740
    References
    more
    • Summaries
      All 70
      Developmental Gene Expression 16
      Gene Ontology 15
      Phenotypes 15
    • Earliest
      J:40256 Gabig TG, et al., Requiem: a novel zinc finger gene essential for apoptosis in myeloid cells. J Biol Chem. 1994 Nov 25;269(47):29515-9
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory