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Ugt8a Gene Detail
Summary
  • Symbol
    Ugt8a
  • Name
    UDP galactosyltransferase 8A
  • Synonyms
    Cgt, mCerGT, Ugt8
  • Feature Type
    protein coding gene
  • IDs
    MGI:109522
    NCBI Gene: 22239
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:125658920-125732268 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 3, 54.68 cM, cytoband E3-F1
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    829 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109522
protein coding gene Chr3:125655071-125732301 (-)
129S1/SvImJ MGP_129S1SvImJ_G0027856
protein coding gene Chr3:128271705-128347736 (-)
A/J MGP_AJ_G0027815
protein coding gene Chr3:123884280-123952995 (-)
AKR/J MGP_AKRJ_G0027780
protein coding gene Chr3:127100950-127170063 (-)
BALB/cJ MGP_BALBcJ_G0027827
protein coding gene Chr3:123743200-123809456 (-)
C3H/HeJ MGP_C3HHeJ_G0027557
protein coding gene Chr3:127460243-127533694 (-)
C57BL/6NJ MGP_C57BL6NJ_G0028272
protein coding gene Chr3:132911057-132989767 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025609
protein coding gene Chr3:119200832-119263490 (-)
CAST/EiJ MGP_CASTEiJ_G0027012
protein coding gene Chr3:126958154-127033119 (-)
CBA/J MGP_CBAJ_G0027532
protein coding gene Chr3:137354662-137426040 (-)
DBA/2J MGP_DBA2J_G0027673
protein coding gene Chr3:123107626-123182775 (-)
FVB/NJ MGP_FVBNJ_G0027641
protein coding gene Chr3:120700002-120777195 (-)
LP/J MGP_LPJ_G0027783
protein coding gene Chr3:129797698-129870531 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0027671
protein coding gene Chr3:145295298-145394495 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0028328
protein coding gene Chr3:126738675-126808248 (-)
PWK/PhJ MGP_PWKPhJ_G0026738
protein coding gene Chr3:122843612-122914359 (-)
SPRET/EiJ MGP_SPRETEiJ_G0026562
protein coding gene Chr3:124780775-124854970 (-)
WSB/EiJ MGP_WSBEiJ_G0027092
protein coding gene Chr3:127423401-127506714 (-)



Homology
more
  • Human Ortholog
    UGT8, UDP glycosyltransferase 8
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    UGT8, UDP glycosyltransferase 8
  • Synonyms
    CGT, UGT4
  • Links
    NCBI Gene ID: 7368
    neXtProt AC: NX_Q16880
    UniProt: Q16880

  • Chr Location
    4q26; chr4:114598402-114678225 (+)  GRCh38

Human Diseases
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  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    18 phenotypes from 2 alleles in 3 genetic backgrounds
    4 phenotypes from multigenic genotypes
    2 images
    39 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mutants fail to make galactolipid galactocerebroside and its sulfated derivative that are normal myelin constituents. Mutants have tremors, ataxia, progressive hindlimb paralysis and vacuole formation in ventral spinal cord due to abnormal myelin sheath.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000032854 Ensembl Gene Model | MGI Sequence Detail 73349 C57BL/6J ±  kb
    transcript ENSMUST00000198610 Ensembl | MGI Sequence Detail 3762 Not Applicable  
    polypeptide ENSMUSP00000143605 Ensembl | MGI Sequence Detail 541 Not Applicable  
    For the selected sequence
    Protein
    Information
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    Molecular
    Reagents
    less
    • All nucleic 42
      Genomic 15
      cDNA 22
      Primer pair 3
      Other 2

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-36113, MGD-MRK-39521, MGI:2139820, MGI:2139983
    References
    more
    • Summaries
      All 84
      Developmental Gene Expression 11
      Diseases 1
      Gene Ontology 7
      Phenotypes 39
    • Earliest
      J:33930 Bosio A, et al., Molecular cloning and characterization of the mouse CGT gene encoding UDP-galactose ceramide-galactosyltransferase (cerebroside synthetase). Genomics. 1996 Jul 1;35(1):223-6
    • Latest
      J:288683 Gacem N, et al., ADAR1 mediated regulation of neural crest derived melanocytes and Schwann cell development. Nat Commun. 2020 Jan 10;11(1):198

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    last database update
    03/12/2024
    MGI 6.23
    The Jackson Laboratory