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Reg3a Gene Detail
Summary
  • Symbol
    Reg3a
  • Name
    regenerating islet-derived 3 alpha
  • Synonyms
    RegIII (alpha)
  • Feature Type
    protein coding gene
  • IDs
    MGI:109408
    NCBI Gene: 19694
  • Alliance
    genome feature page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:78357692-78360810 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 34.76 cM, cytoband C
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    190 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109408
 protein coding gene Chr6:78357692-78360822 (+)
129S1/SvImJ ENSMUSG00200011054
 protein coding gene Chr6:75271511-75274631 (+)
A/J ENSMUSG00195012035
 protein coding gene Chr6:74974357-74977479 (+)
AKR/J ENSMUSG00220001958
 protein coding gene Chr6:74007088-74010192 (+)
BALB/cJ ENSMUSG00180008935
 protein coding gene Chr6:75376048-75379168 (+)
C3H/HeJ ENSMUSG00175012117
 protein coding gene Chr6:102057618-102060736 (-)
C57BL/6NJ ENSMUSG00215007062
 protein coding gene Chr6:75360225-75363345 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028521
 protein coding gene Chr6:74919861-74923079 (+)
CAST/EiJ ENSTCUG00005008153
 protein coding gene Chr6:75481590-75485286 (+)
CBA/J ENSMUSG00210011214
 protein coding gene Chr6:75187264-75190384 (+)
DBA/2J ENSMUSG00185000849
 protein coding gene Chr6:75740731-75743850 (+)
FVB/NJ ENSMUSG00205015433
 protein coding gene Chr6:74451082-74454198 (+)
JF1/MsJ ENSUMUG00000009334
 protein coding gene Chr6:74834524-74837701 (+)
LP/J ENSMUSG00230006162
 protein coding gene Chr6:76843755-76846875 (+)
NOD/ShiLtJ ENSMUSG00190001388
 protein coding gene Chr6:74815994-74819110 (+)
NZO/HlLtJ ENSMUSG00225006794
 protein coding gene Chr6:78835371-78838524 (+)
PWK/PhJ ENSLUMG00010005940
 protein coding gene Chr6:74252354-74256073 (+)
SPRET/EiJ ENSMSPG00010000348
 protein coding gene Chr6:76204114-76207138 (+)
WSB/EiJ ENSIUOG00005018128
 protein coding gene Chr6:75792822-75795956 (+)



Homology
more
  • Human Ortholog
    REG3A, regenerating family member 3 alpha
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    REG3A, regenerating family member 3 alpha
  • Synonyms
    HIP, HIP/PAP, INGAP, PAP, PAP1, PAP-H, PBCGF, REG3, REG-III
  • Links
    NCBI Gene ID: 5068
    UniProt: Q06141

  • Chr Location
    2p12; chr2:79157003-79159753 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotype references
  • All Mutations and Alleles
    7
  • Endonuclease-mediated
    5
  • Spontaneous
    1
  • Targeted
    1
  • Genomic Mutations
    2 involving Reg3a
  • Incidental Mutations
    APF
  • Find Mice (IMSR)
    17 strains or lines available
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    22
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    601
  • Tissues
    4
  • cDNA Data
    8
  • Literature Summary
    3
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000079516 Ensembl Gene Model | MGI Sequence Detail 3119 C57BL/6J ±  kb
transcript ENSMUST00000101272 Ensembl | MGI Sequence Detail 825 Not Applicable  
polypeptide ENSMUSP00000098829 Ensembl | MGI Sequence Detail 175 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    4 Sequences
  • InterPro Domains
    IPR050111 C-type lectin and snaclec domain-containing protein
    IPR018378 C-type lectin, conserved site
    IPR016187 C-type lectin fold
    IPR001304 C-type lectin-like
    IPR016186 C-type lectin-like/link domain superfamily
Molecular
Reagents
less
  • All nucleic 11
    Genomic 2
    cDNA 8
    Primer pair 1

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-38453, MGI:2141615
References
more
  • Summaries
    All 44
    Developmental Gene Expression 3
    Gene Ontology 5
    Phenotypes 13
  • Earliest
    J:38547 Narushima Y, et al., Structure, chromosomal localization and expression of mouse genes encoding type III Reg, RegIII alpha, RegIII beta, RegIII gamma. Gene. 1997 Feb 7;185(2):159-68
  • Latest
    J:386463 Rias E, et al., Protocol for isolation of total RNA from mouse whole cochlea using organic solvents. STAR Protoc. 2026 Mar 20;7(1):104376
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory