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Nek2 Gene Detail
Summary
  • Symbol
    Nek2
  • Name
    NIMA (never in mitosis gene a)-related expressed kinase 2
  • Feature Type
    protein coding gene
  • IDs
    MGI:109359
    NCBI Gene: 18005
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:191553622-191565161 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 96.94 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    382 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109359
 protein coding gene Chr1:191553556-191565162 (+)
129S1/SvImJ ENSMUSG00200004256
 protein coding gene Chr1:189337262-189348916 (+)
A/J ENSMUSG00195008022
 protein coding gene Chr1:188916638-188928292 (+)
AKR/J ENSMUSG00220004671
 protein coding gene Chr1:188160507-188172163 (+)
BALB/cJ ENSMUSG00180016419
 protein coding gene Chr1:188982089-188993743 (+)
C3H/HeJ ENSMUSG00175020563
 protein coding gene Chr1:189170012-189181666 (+)
C57BL/6NJ ENSMUSG00215012603
 protein coding gene Chr1:188386404-188398010 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015055
 protein coding gene Chr1:181634086-181645868 (+)
CAST/EiJ ENSTCUG00005001923
 protein coding gene Chr1:186952393-186964056 (+)
CBA/J ENSMUSG00210003350
 protein coding gene Chr1:188832295-188843949 (+)
DBA/2J ENSMUSG00185010100
 protein coding gene Chr1:193445571-193457221 (+)
FVB/NJ ENSMUSG00205003637
 protein coding gene Chr1:187828110-187839764 (+)
JF1/MsJ ENSUMUG00000006590
 protein coding gene Chr1:192425534-192437220 (+)
LP/J ENSMUSG00230024207
 protein coding gene Chr1:192980895-192992549 (+)
NOD/ShiLtJ ENSMUSG00190031656
 protein coding gene Chr1:188807945-188819597 (+)
NZO/HlLtJ ENSMUSG00225015331
 protein coding gene Chr1:196733394-196745054 (+)
PWK/PhJ ENSLUMG00010005967
 protein coding gene Chr1:187664522-187676176 (+)
SPRET/EiJ ENSMSPG00010022126
 protein coding gene Chr1:191202264-191213791 (+)
WSB/EiJ ENSIUOG00005004442
 protein coding gene Chr1:188170318-188181990 (+)



Homology
more
  • Human Ortholog
    NEK2, NIMA related kinase 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NEK2, NIMA related kinase 2
  • Synonyms
    HsPK21, NEK2A, NLK1, PPP1R111, RP67
  • Links
    NCBI Gene ID: 4751
    UniProt: P51955

  • Chr Location
    1q32.3; chr1:211658256-211675663 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human NEK2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 2 alleles in 2 genetic backgrounds
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    69
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    649
  • Tissues
    31
  • cDNA Data
    26
  • Literature Summary
    14
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 18005 NCBI Gene Model | MGI Sequence Detail 11540 C57BL/6J ±  kb
    transcript NM_010892 RefSeq | MGI Sequence Detail 3160 ZRU/MplStud  
    polypeptide O35942 UniProt | EBI | MGI Sequence Detail 443 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 33
      cDNA 26
      Primer pair 7
      Antibodies 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-38404, MGI:2138121, MGI:2138656
    References
    more
    • Summaries
      All 65
      Developmental Gene Expression 14
      Gene Ontology 13
      Phenotypes 14
    • Earliest
      J:13545 Biesecker LG, et al., Identification of four murine cDNAs encoding putative protein kinases from primitive embryonic stem cells differentiated in vitro. Proc Natl Acad Sci U S A. 1993 Aug 1;90(15):7044-8
    • Latest
      J:373442 Zhou Y, et al., Loss-of-function variants in ciliary genes confer high risk for tetralogy of Fallot. Sci Adv. 2025 Oct 10;11(41):eadt0836
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory