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Htr2b Gene Detail
Summary
  • Symbol
    Htr2b
  • Name
    5-hydroxytryptamine (serotonin) receptor 2B
  • Synonyms
    5-HT2B
  • Feature Type
    protein coding gene
  • IDs
    MGI:109323
    NCBI Gene: 15559
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:86026748-86039692 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 1, 43.94 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    101 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109323
protein coding gene Chr1:86025268-86043960 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016242
protein coding gene Chr1:87338020-87350963 (-)
A/J MGP_AJ_G0016223
protein coding gene Chr1:84104587-84117530 (-)
AKR/J MGP_AKRJ_G0016184
protein coding gene Chr1:86536644-86551189 (-)
BALB/cJ MGP_BALBcJ_G0016180
protein coding gene Chr1:84220619-84233379 (-)
C3H/HeJ MGP_C3HHeJ_G0016008
protein coding gene Chr1:86793295-86806238 (-)
C57BL/6NJ MGP_C57BL6NJ_G0016636
protein coding gene Chr1:90663165-90676109 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014358
protein coding gene Chr1:78601147-78612411 (-)
CAST/EiJ MGP_CASTEiJ_G0015593
protein coding gene Chr1:86029817-86042704 (-)
CBA/J MGP_CBAJ_G0015984
protein coding gene Chr1:93482898-93495842 (-)
DBA/2J MGP_DBA2J_G0016087
protein coding gene Chr1:83413731-83426682 (-)
FVB/NJ MGP_FVBNJ_G0016086
protein coding gene Chr1:82458336-82471279 (-)
LP/J MGP_LPJ_G0016158
protein coding gene Chr1:88442566-88455509 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016112
protein coding gene Chr1:96768017-96781152 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0016679
protein coding gene Chr1:86663607-86677566 (-)
PWK/PhJ MGP_PWKPhJ_G0015380
protein coding gene Chr1:82695274-82708531 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015160
protein coding gene Chr1:85645849-85658664 (-)
WSB/EiJ MGP_WSBEiJ_G0015657
protein coding gene Chr1:86310471-86323418 (-)



Homology
more
  • Human Ortholog
    HTR2B, 5-hydroxytryptamine receptor 2B
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HTR2B, 5-hydroxytryptamine receptor 2B
  • Synonyms
    5-HT2B, 5-HT-2B, 5-HT(2B)
  • Links
    NCBI Gene ID: 3357
    neXtProt AC: NX_P41595
    UniProt: P41595

  • Chr Location
    2q37.1; chr2:231108230-231125042 (-)  GRCh38

Human Diseases
more
  • Diseases
    2 with human HTR2B associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    25 phenotypes from 4 alleles in 5 genetic backgrounds
    15 phenotypes from multigenic genotypes
    50 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation exhibit a lack of cardiac trabeculae, ventricular hypoplasia due to impaired myocyte proliferation, and midgestational and neonatal lethality of variable severity.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000026228 Ensembl Gene Model | MGI Sequence Detail 12945 C57BL/6J ±  kb
    transcript ENSMUST00000027431 Ensembl | MGI Sequence Detail 2083 Not Applicable  
    polypeptide ENSMUSP00000027431 Ensembl | MGI Sequence Detail 479 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 16
      Genomic 2
      cDNA 7
      Primer pair 5
      Other 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-38368, MGI:2138380, MGI:2138536
    References
    more
    • Summaries
      All 109
      Developmental Gene Expression 14
      Diseases 1
      Gene Ontology 14
      Phenotypes 50
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:339295 Benhadda A, et al., 5-HT(1A) and 5-HT(2B) receptor interaction and co-clustering regulate serotonergic neuron excitability. iScience. 2023 Aug 18;26(8):107401

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    last database update
    03/12/2024
    MGI 6.23
    The Jackson Laboratory