About   Help   FAQ
Lama4 Gene Detail
Summary
  • Symbol
    Lama4
  • Name
    laminin, alpha 4
  • Synonyms
    laminin [a]4
  • Feature Type
    protein coding gene
  • IDs
    MGI:109321
    NCBI Gene: 16775
  • Alliance
    genome feature page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:38841511-38986184 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 20.02 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    4606 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109321
 protein coding gene Chr10:38841511-38986184 (+)
129S1/SvImJ ENSMUSG00200008020
 protein coding gene Chr10:35696538-35843113 (+)
A/J ENSMUSG00195017026
 protein coding gene Chr10:35999255-36145836 (+)
AKR/J ENSMUSG00220026497
 protein coding gene Chr10:35675919-35822500 (+)
BALB/cJ ENSMUSG00180015172
 protein coding gene Chr10:36084565-36231132 (+)
C3H/HeJ ENSMUSG00175011182
 protein coding gene Chr10:35878596-36025508 (+)
C57BL/6NJ ENSMUSG00215009268
 protein coding gene Chr10:35629458-35776025 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015242
 protein coding gene Chr10:34455533-34598239 (+)
CAST/EiJ ENSTCUG00005025924
 protein coding gene Chr10:36067301-36214214 (+)
CBA/J ENSMUSG00210025047
 protein coding gene Chr10:35772431-35919007 (+)
DBA/2J ENSMUSG00185006985
 protein coding gene Chr10:35924962-36071535 (+)
FVB/NJ ENSMUSG00205011426
 protein coding gene Chr10:35839582-35986153 (+)
JF1/MsJ ENSUMUG00000017771
 protein coding gene Chr10:35672423-35818647 (+)
LP/J ENSMUSG00230015261
 protein coding gene Chr10:37685625-37832188 (+)
NOD/ShiLtJ ENSMUSG00190028916
 protein coding gene Chr10:36053385-36199927 (+)
NZO/HlLtJ ENSMUSG00225017391
 protein coding gene Chr10:42010798-42159055 (+)
PWK/PhJ ENSLUMG00010007316
 protein coding gene Chr10:35796004-35942170 (+)
SPRET/EiJ ENSMSPG00010018961
 protein coding gene Chr10:36833935-36980229 (+)
WSB/EiJ ENSIUOG00005014788
 protein coding gene Chr10:35579385-35730573 (+)



Homology
more
  • Human Ortholog
    LAMA4, laminin subunit alpha 4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LAMA4, laminin subunit alpha 4
  • Synonyms
    CMD1JJ, LAMA3, LAMA4*-1
  • Links
    NCBI Gene ID: 3910
    UniProt: Q16363

  • Chr Location
    6q21; chr6:112106077-112254985 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human LAMA4 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    53 phenotypes from 2 alleles in 3 genetic backgrounds
    16 phenotypes from multigenic genotypes
    7 images
    52 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit impaired motor control of the hind limbs associated with improperly positioned synaptic active zones and junctional folds, and prenatal and neonatal hemorrhages associated with capillary defects.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    30
  • GO References
    18
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    791
  • Tissues
    102
  • cDNA Data
    92
  • Literature Summary
    57
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 16775 NCBI Gene Model | MGI Sequence Detail 144674 C57BL/6J ±  kb
    transcript NM_010681 RefSeq | MGI Sequence Detail 6046 ZRU/MplStud  
    polypeptide P97927 UniProt | EBI | MGI Sequence Detail 1816 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      6 Sequences
    • Protein Ontology
      PR:000009653 laminin subunit alpha-4
      (term hierarchy)
    • InterPro Domains
      IPR013320 Concanavalin A-like lectin/glucanase domain superfamily
      IPR000742 EGF-like domain
      IPR009254 Laminin alpha, domain I
      IPR056863 Laminin/attractin/netrin-like, EGF domain
      IPR001791 Laminin G domain
      IPR050440 Laminin/Netrin Extracellular Matrix
      IPR002049 Laminin-type EGF domain
      IPR050372 Neurexin-related cell adhesion and synaptic protein
    • GlyGen
      P97927 21 sites, 12 N-linked glycans (10 sites), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 106
      Genomic 2
      cDNA 97
      Primer pair 5
      Other 2
      Antibodies 6

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-38366
    References
    more
    • Summaries
      All 154
      Developmental Gene Expression 57
      Gene Ontology 18
      Phenotypes 52
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:380950 Deshpande T, et al., Vascular basement membrane laminins modulate functional zonation of cerebral microvessels. J Cereb Blood Flow Metab. 2026 Feb 16;:271678X251410040
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory