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Fzd8 Gene Detail
Summary
  • Symbol
    Fzd8
  • Name
    frizzled class receptor 8
  • Synonyms
    Fz8, mFZ8
  • Feature Type
    protein coding gene
  • IDs
    MGI:108460
    NCBI Gene: 14370
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:9212856-9216201 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 18, 4.91 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    81 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_108460
 protein coding gene Chr18:9212163-9218136 (+)
129S1/SvImJ ENSMUSG00200022835
 protein coding gene Chr18:6155067-6161041 (+)
A/J ENSMUSG00195007883
 protein coding gene Chr18:6333000-6338975 (+)
AKR/J ENSMUSG00220018487
 protein coding gene Chr18:6324181-6330156 (+)
BALB/cJ ENSMUSG00180005223
 protein coding gene Chr18:6768921-6774895 (+)
C3H/HeJ ENSMUSG00175007020
 protein coding gene Chr18:6304273-6310247 (+)
C57BL/6NJ ENSMUSG00215017395
 protein coding gene Chr18:6048395-6054368 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021983
 protein coding gene Chr18:5679968-5683312 (+)
CAST/EiJ ENSTCUG00005016090
 protein coding gene Chr18:6205439-6211399 (+)
CBA/J ENSMUSG00210021805
 protein coding gene Chr18:6317221-6323195 (+)
DBA/2J ENSMUSG00185028173
 protein coding gene Chr18:6326698-6332671 (+)
FVB/NJ ENSMUSG00205020848
 protein coding gene Chr18:6112928-6118901 (+)
JF1/MsJ ENSUMUG00000023437
 protein coding gene Chr18:6402635-6408609 (+)
LP/J ENSMUSG00230026158
 protein coding gene Chr18:8399668-8405642 (+)
NOD/ShiLtJ ENSMUSG00190009539
 protein coding gene Chr18:6099522-6105495 (+)
NZO/HlLtJ ENSMUSG00225033527
 protein coding gene Chr18:8310172-8316145 (+)
PWK/PhJ ENSLUMG00010008595
 protein coding gene Chr18:6590371-6596342 (+)
SPRET/EiJ ENSMSPG00010010640
 protein coding gene Chr18:6227137-6233112 (+)
WSB/EiJ ENSIUOG00005025616
 protein coding gene Chr18:6176391-6182364 (+)



Homology
more
  • Human Ortholog
    FZD8, frizzled class receptor 8
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FZD8, frizzled class receptor 8
  • Synonyms
    FZ-8, hFZ8
  • Links
    NCBI Gene ID: 8325
    UniProt: Q9H461

  • Chr Location
    10p11.21; chr10:35638247-35642296 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 3 alleles in 3 genetic backgrounds
    4 phenotypes from multigenic genotypes
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene does not appear to result in a phenotype.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    55
  • GO References
    27
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1242
  • Tissues
    375
  • cDNA Data
    29
  • Literature Summary
    73
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 14370 NCBI Gene Model | MGI Sequence Detail 3346 C57BL/6J ±  kb
    transcript NM_008058 RefSeq | MGI Sequence Detail 3346 Not Specified  
    polypeptide Q61091 UniProt | EBI | MGI Sequence Detail 685 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 60
      Genomic 1
      cDNA 31
      Primer pair 21
      Other 7

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGD-MRK-37504
    References
    more
    • Summaries
      All 131
      Developmental Gene Expression 73
      Gene Ontology 27
      Phenotypes 14
    • Earliest
      J:37068 Wang Y, et al., A large family of putative transmembrane receptors homologous to the product of the Drosophila tissue polarity gene frizzled. J Biol Chem. 1996 Feb 23;271(8):4468-76
    • Latest
      J:366779 Liu J, et al., A human-specific enhancer fine-tunes radial glia potency and corticogenesis. Nature. 2025 May 14;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory