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Rgs4 Gene Detail
Summary
  • Symbol
    Rgs4
  • Name
    regulator of G-protein signaling 4
  • Synonyms
    ESTM48, ESTM50
  • Feature Type
    protein coding gene
  • IDs
    MGI:108409
    NCBI Gene: 19736
  • Alliance
    genome feature page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:169569046-169575211 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 76.84 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    252 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_108409
 protein coding gene Chr1:169569046-169575211 (-)
129S1/SvImJ ENSMUSG00200042685
 protein coding gene Chr1:167031036-167037218 (-)
A/J ENSMUSG00195045176
 protein coding gene Chr1:166348980-166355119 (-)
AKR/J ENSMUSG00220028027
 protein coding gene Chr1:166060631-166066792 (-)
BALB/cJ ENSMUSG00180039378
 protein coding gene Chr1:166627728-166633899 (-)
C3H/HeJ ENSMUSG00175047066
 protein coding gene Chr1:166687428-166693612 (-)
C57BL/6NJ ENSMUSG00215041669
 protein coding gene Chr1:166509716-166515881 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014832
 protein coding gene Chr1:160011470-160017618 (-)
CAST/EiJ ENSTCUG00005043807
 protein coding gene Chr1:165020274-165026447 (-)
CBA/J ENSMUSG00210035721
 protein coding gene Chr1:166593608-166599777 (-)
DBA/2J ENSMUSG00185011394
 protein coding gene Chr1:170810383-170816552 (-)
FVB/NJ ENSMUSG00205020210
 protein coding gene Chr1:165549572-165555752 (-)
JF1/MsJ ENSUMUG00000007299
 protein coding gene Chr1:169953445-169959608 (-)
LP/J ENSMUSG00230025898
 protein coding gene Chr1:170418683-170424863 (-)
NOD/ShiLtJ ENSMUSG00190026630
 protein coding gene Chr1:166348892-166355033 (-)
NZO/HlLtJ ENSMUSG00225004393
 protein coding gene Chr1:174030685-174036862 (-)
PWK/PhJ ENSLUMG00010032034
 protein coding gene Chr1:165321275-165327431 (-)
SPRET/EiJ ENSMSPG00010047260
 protein coding gene Chr1:168891621-168895650 (-)
WSB/EiJ ENSIUOG00005034294
 protein coding gene Chr1:165772478-165778662 (-)



Homology
more
  • Human Ortholog
    RGS4, regulator of G protein signaling 4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RGS4, regulator of G protein signaling 4
  • Synonyms
    RGP4, SCZD9
  • Links
    NCBI Gene ID: 5999
    UniProt: P49798

  • Chr Location
    1q23.3; chr1:163068775-163076802 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human RGS4 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    26 phenotypes from 6 alleles in 7 genetic backgrounds
    19 phenotypes from multigenic genotypes
    33 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for one null allele display background dependent partially penetrant embryonic lethality, decreased body weight, and mildly impaired coordination. Another allele displays increased cholesterol levels in males. Mice homozygous for a different null allele exhibit no abnormal phenotype.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    24
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1135
  • Tissues
    207
  • cDNA Data
    53
  • Literature Summary
    30
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 19736 NCBI Gene Model | MGI Sequence Detail 6166 C57BL/6J ±  kb
    transcript NM_009062 RefSeq | MGI Sequence Detail 2952 C57BL/6  
    polypeptide O08899 UniProt | EBI | MGI Sequence Detail 205 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 64
      cDNA 55
      Primer pair 7
      Other 2
      Antibodies 1

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGD-MRK-37452, MGI:1334420, MGI:1334426
    References
    more
    • Summaries
      All 109
      Developmental Gene Expression 30
      Gene Ontology 5
      Phenotypes 33
    • Earliest
      J:36569 Chen CK, et al., RGS-r, a retinal specific RGS protein, binds an intermediate conformation of transducin and enhances recycling. Proc Natl Acad Sci U S A. 1996 Nov 12;93(23):12885-9
    • Latest
      J:380949 Kiyama T, et al., Tbr2-dependent parallel pathways regulate the development of distinct ipRGC subtypes. Commun Biol. 2026 Feb 1;9(1)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory