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Rgs8 Gene Detail
Summary
  • Symbol
    Rgs8
  • Name
    regulator of G-protein signaling 8
  • Synonyms
    6530413N01Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:108408
    NCBI Gene: 67792
  • Alliance
    genome feature page
  • Transcription Start Sites
    15 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:153528612-153573415 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 65.41 cM, cytoband G2
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1219 from dbSNP Build 142
  • Strain Annotations
    27
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_108408
 protein coding gene Chr1:153528612-153576069 (+)
129S1/SvImJ ENSMUSG00200002179
 protein coding gene Chr1:151012160-151017004 (+)
129S1/SvImJ ENSMUSG00200002188
 protein coding gene Chr1:150969713-151014036 (+)
A/J ENSMUSG00195013495
 protein coding gene Chr1:150389730-150394574 (+)
A/J ENSMUSG00195013503
 protein coding gene Chr1:150347281-150391606 (+)
AKR/J ENSMUSG00220005466
 protein coding gene Chr1:150198510-150203354 (+)
AKR/J ENSMUSG00220005473
 protein coding gene Chr1:150156064-150200386 (+)
BALB/cJ ENSMUSG00180032100
 protein coding gene Chr1:150576932-150621250 (+)
BALB/cJ ENSMUSG00180032084
 protein coding gene Chr1:150619374-150624218 (+)
C3H/HeJ ENSMUSG00175002601
 protein coding gene Chr1:150656233-150661077 (+)
C3H/HeJ ENSMUSG00175002603
 protein coding gene Chr1:150613787-150658109 (+)
C57BL/6NJ ENSMUSG00215003398
 protein coding gene Chr1:150554405-150559249 (+)
C57BL/6NJ ENSMUSG00215003400
 protein coding gene Chr1:150511950-150556281 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014711
 protein coding gene Chr1:144390897-144438220 (+)
CAST/EiJ ENSTCUG00005005340
 protein coding gene Chr1:149162696-149209963 (+)
CBA/J ENSMUSG00210031682
 protein coding gene Chr1:150517555-150561878 (+)
CBA/J ENSMUSG00210031664
 protein coding gene Chr1:150560002-150564846 (+)
DBA/2J ENSMUSG00185040596
 protein coding gene Chr1:154809566-154856616 (+)
FVB/NJ ENSMUSG00205024868
 protein coding gene Chr1:149649594-149696704 (+)
JF1/MsJ ENSUMUG00000014694
 protein coding gene Chr1:153957861-154002235 (+)
LP/J ENSMUSG00230012179
 protein coding gene Chr1:154371308-154418571 (+)
NOD/ShiLtJ ENSMUSG00190012291
 protein coding gene Chr1:150365975-150413030 (+)
NZO/HlLtJ ENSMUSG00225004944
 protein coding gene Chr1:158073044-158077888 (+)
NZO/HlLtJ ENSMUSG00225004950
 protein coding gene Chr1:158030597-158074920 (+)
PWK/PhJ ENSLUMG00010028570
 protein coding gene Chr1:149315791-149360101 (+)
SPRET/EiJ ENSMSPG00010005037
 protein coding gene Chr1:152641427-152676315 (+)
WSB/EiJ ENSIUOG00005022964
 protein coding gene Chr1:149937868-149984984 (+)



Homology
more
  • Human Ortholog
    RGS8, regulator of G protein signaling 8
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RGS8, regulator of G protein signaling 8
  • Links
    NCBI Gene ID: 85397
    UniProt: P57771

  • Chr Location
    1q25.3; chr1:182641816-182752376 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 2 alleles in 2 genetic backgrounds
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit normal fertility and Purkinje cell morphology.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    35
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    645
  • Tissues
    32
  • cDNA Data
    78
  • Literature Summary
    7
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 67792 NCBI Gene Model | MGI Sequence Detail 44804 C57BL/6J ±  kb
transcript NM_026380 RefSeq | MGI Sequence Detail 5827 C57BL/6  
polypeptide Q8BXT1 UniProt | EBI | MGI Sequence Detail 180 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 79
    cDNA 79

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-37451, MGI:1915042
References
more
  • Summaries
    All 55
    Developmental Gene Expression 7
    Gene Ontology 9
    Phenotypes 10
  • Earliest
    J:36569 Chen CK, et al., RGS-r, a retinal specific RGS protein, binds an intermediate conformation of transducin and enhances recycling. Proc Natl Acad Sci U S A. 1996 Nov 12;93(23):12885-9
  • Latest
    J:385686 Steklikova K, et al., Factors Involved in Enamel Knot Establishment and Cap Formation. J Dent Res. 2025 Jul;104(7):784-794
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/01/2026
MGI 6.24 		The Jackson Laboratory