Kif1a MGI Mouse Gene Detail - MGI:108391 - kinesin family member 1A

Symbol

Kif1a
Name

kinesin family member 1A
Synonyms

ATSV, C630002N23Rik, Kns1, LOC381283, N-3 kinesin

Feature Type

protein coding gene
IDs

MGI:108391
NCBI Gene: 16560
Alliance

genome feature page
Transcription Start Sites

14 TSS

Sequence Map

Chr1:92943186-93029673 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 46.74 cM, cytoband E1-E2
Mapping Data

3 experiments

SNPs within 2kb

2241 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_108391	protein coding gene	Chr1:92943180-93029760 (-)
129S1/SvImJ	ENSMUSG00200037587	protein coding gene	Chr1:90163715-90230649 (-)
A/J	ENSMUSG00195029719	protein coding gene	Chr1:89722551-89789495 (-)
AKR/J	ENSMUSG00220044687	protein coding gene	Chr1:89872771-89939796 (-)
BALB/cJ	ENSMUSG00180014181	protein coding gene	Chr1:90035278-90102303 (-)
C3H/HeJ	ENSMUSG00175001003	protein coding gene	Chr1:89917748-89984742 (-)
C57BL/6NJ	ENSMUSG00215028566	protein coding gene	Chr1:89844941-89911949 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014447	protein coding gene	Chr1:85485249-85573648 (-)
CAST/EiJ	ENSTCUG00005006782	protein coding gene	Chr1:89498928-89567681 (-)
CBA/J	ENSMUSG00210011876	protein coding gene	Chr1:89762952-89829942 (-)
DBA/2J	ENSMUSG00185012945	protein coding gene	Chr1:94235960-94302900 (-)
FVB/NJ	ENSMUSG00205039753	protein coding gene	Chr1:89160995-89228018 (-)
JF1/MsJ	ENSUMUG00000012238	protein coding gene	Chr1:92974229-93042921 (-)
LP/J	ENSMUSG00230019760	protein coding gene	Chr1:93499831-93566763 (-)
NOD/ShiLtJ	ENSMUSG00190020299	protein coding gene	Chr1:89803000-89870022 (-)
NZO/HlLtJ	ENSMUSG00225003362	protein coding gene	Chr1:97398130-97465054 (-)
PWK/PhJ	ENSLUMG00010038908	protein coding gene	Chr1:89361335-89430049 (-)
SPRET/EiJ	ENSMSPG00010044141	protein coding gene	Chr1:91387333-91475361 (-)
WSB/EiJ	ENSIUOG00005033604	protein coding gene	Chr1:89460070-89527268 (-)

Human Ortholog

KIF1A, kinesin family member 1A

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

KIF1A, kinesin family member 1A
Synonyms

ATSV, C2orf20, HSN2C, MRD9, NESCAVS, SPG30, SPG30A, SPG30B, UNC104
Links

HGNC:888

NCBI Gene ID: 547

UniProt: Q12756
Chr Location

2q37.3; chr2:240713761-240824320 (-) GRCh38

MGI Vertebrate Homology

Kif1a stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: KIF1A
Gene Tree

Kif1a

Diseases

1 with Kif1a mouse models; 7 with human KIF1A associations

Human Disease

Mouse Models

hereditary spastic paraplegia 30

IDs

View 2 models

hereditary sensory and autonomic neuropathy

IDs

hereditary sensory neuropathy type 2C

IDs

hereditary spastic paraplegia

IDs

hereditary spastic paraplegia 30A

IDs

hereditary spastic paraplegia 30B

IDs

NESCAV syndrome

IDs

Click on a disease name to see all genes associated with that disease.

Mutations/Alleles

2 with disease annotations

References

1 with disease annotations

less

Phenotype Summary

21 phenotypes from 3 alleles in 3 genetic backgrounds
3 images
16 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

14
Chemically induced (other)

1
Endonuclease-mediated

6
Gene trapped

1
Radiation induced

1
Spontaneous

2
Targeted

3
Genomic Mutations

2 involving Kif1a
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

97 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Most mice homozygous for a null allele die within a day of birth, with reduced motor and sensory deficits, decreased synaptic vesicle precursor transport, and significant neuronal degeneration in the central nervous system, but two point mutant alleles cause progressive hindleg paralysis

less

All GO Annotations

60
GO References

13

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

806
Tissues

57
cDNA Data

337
Literature Summary

9

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase kif1a

less

All Sequences

96
RefSeq

26
UniProt

16
CCDS

CCDS48326.1, CCDS48327.1, CCDS78651.1, CCDS78652.1

Ensembl

ENSMUSG00000014602 (Evidence)
NCBI Gene

16560

			Length	Strain/Species	Flank
genomic	ENSMUSG00000014602	Ensembl Gene Model \| MGI Sequence Detail	86488	C57BL/6J	± kb
transcript	ENSMUST00000190723	Ensembl \| MGI Sequence Detail	6141	Not Applicable
polypeptide	ENSMUSP00000140163	Ensembl \| MGI Sequence Detail	1791	Not Applicable

less

UniProt

16 Sequences
Protein Ontology

PR:000009295 kinesin-like protein KIF1A

(term hierarchy)
PDB

1I5S, 1I6I, 1IA0, 1VFV, 1VFW, 1VFX, 1VFZ, 2HXF, 2HXH, 2ZFI, 2ZFJ, 2ZFK, 2ZFL, 2ZFM, 7EO9, 7EOB
EC

5.6.1.3
InterPro Domains

IPR000253 Forkhead-associated (FHA) domain

IPR032405 Kinesin-associated

IPR022164 Kinesin-like

IPR022140 Kinesin-like KIF1-type

IPR049780 Kinesin-like protein KIF1A/B, pleckstrin homology domain

IPR049779 Kinesin-like protein KIF1A, forkhead associated domain

IPR001752 Kinesin motor domain

IPR019821 Kinesin motor domain, conserved site

IPR036961 Kinesin motor domain superfamily

IPR011993 PH-like domain superfamily

IPR001849 Pleckstrin homology domain

IPR027417 P-loop containing nucleoside triphosphate hydrolase

IPR008984 SMAD/FHA domain superfamily
GlyGen

P33173 4 sites, 3 N-linked glycans (3 sites), 1 O-linked glycan (1 site)

less

All nucleic 339

cDNA 337

Primer pair 2

Antibodies 1

Microarray probesets 4

less

MGD-MRK-11590, MGD-MRK-37431, MGI:2686472

Summaries

All 74

Developmental Gene Expression 9

Diseases 1

Gene Ontology 13

Phenotypes 16
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:390047 Hatton CL, et al., Genetic Deletion of Sarm1 in Mouse Models of Three Neurological Diseases. J Peripher Nerv Syst. 2025 Sep;30(3):e70052

TSS for Kif1a:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr13007	Chr1:93029576-93029601 (-)	84 bp
Tssr13006	Chr1:93029547-93029571 (-)	114 bp
Tssr13005	Chr1:93029532-93029543 (-)	135 bp
Tssr13004	Chr1:93011693-93011696 (-)	17,978 bp
Tssr13003	Chr1:93003965-93003977 (-)	25,702 bp
Tssr13002	Chr1:93003948-93003960 (-)	25,719 bp
Tssr13001	Chr1:93003919-93003930 (-)	25,748 bp
Tssr13000	Chr1:93000813-93000826 (-)	28,853 bp
Tssr12998	Chr1:92996401-92996441 (-)	33,252 bp
Tssr12997	Chr1:92950863-92950875 (-)	78,804 bp
Tssr12996	Chr1:92950793-92950842 (-)	78,855 bp
Tssr12995	Chr1:92943801-92943813 (-)	85,866 bp
Tssr12994	Chr1:92943771-92943787 (-)	85,894 bp
Tssr12993	Chr1:92943694-92943770 (-)	85,941 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/01/2026 MGI 6.24