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Dhx9 Gene Detail
Summary
  • Symbol
    Dhx9
  • Name
    DExH-box helicase 9
  • Synonyms
    Ddx9, leukophysin, NDH II, NDHII, nuclear DNA helicase II, RHA, RNA helicase
  • Feature Type
    protein coding gene
  • IDs
    MGI:108177
    NCBI Gene: 13211
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:153331504-153363406 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 65.37 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    700 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_108177
 protein coding gene Chr1:153331504-153363464 (-)
129S1/SvImJ ENSMUSG00200002019
 protein coding gene Chr1:150772443-150804346 (-)
A/J ENSMUSG00195013449
 protein coding gene Chr1:150149968-150181870 (-)
AKR/J ENSMUSG00220005617
 protein coding gene Chr1:149958776-149990678 (-)
BALB/cJ ENSMUSG00180031399
 protein coding gene Chr1:150379688-150411593 (-)
C3H/HeJ ENSMUSG00175002788
 protein coding gene Chr1:150416510-150448412 (-)
C57BL/6NJ ENSMUSG00215003347
 protein coding gene Chr1:150314636-150346540 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014709
 protein coding gene Chr1:144193948-144230026 (-)
CAST/EiJ ENSTCUG00005005530
 protein coding gene Chr1:148968222-149000179 (-)
CBA/J ENSMUSG00210030657
 protein coding gene Chr1:150320297-150352199 (-)
DBA/2J ENSMUSG00185043523
 protein coding gene Chr1:154608411-154640286 (-)
FVB/NJ ENSMUSG00205028750
 protein coding gene Chr1:149450224-149482114 (-)
JF1/MsJ ENSUMUG00000014112
 protein coding gene Chr1:153757676-153789578 (-)
LP/J ENSMUSG00230013603
 protein coding gene Chr1:154176512-154208394 (-)
NOD/ShiLtJ ENSMUSG00190011795
 protein coding gene Chr1:150164842-150196716 (-)
NZO/HlLtJ ENSMUSG00225005711
 protein coding gene Chr1:157833360-157865262 (-)
PWK/PhJ ENSLUMG00010028343
 protein coding gene Chr1:149115549-149147413 (-)
SPRET/EiJ ENSMSPG00010005004
 protein coding gene Chr1:152432896-152464995 (-)
WSB/EiJ ENSIUOG00005022026
 protein coding gene Chr1:149738093-149769980 (-)



Homology
more
  • Human Ortholog
    DHX9, DExH-box helicase 9
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DHX9, DExH-box helicase 9
  • Synonyms
    DDX9, LKP, MRD75, NDH2, NDHII, RHA
  • Links
    NCBI Gene ID: 1660
    UniProt: Q08211

  • Chr Location
    1q25.3; chr1:182839302-182887982 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human DHX9 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    26 phenotypes from 3 alleles in 4 genetic backgrounds
    1 phenotype from multigenic genotypes
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes die in embryonic stages with massive apoptotic cell death in embryonic ectodermal cells.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    169
  • GO References
    16
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    953
  • Tissues
    102
  • cDNA Data
    70
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000042699 Ensembl Gene Model | MGI Sequence Detail 31903 C57BL/6J ±  kb
    transcript ENSMUST00000042141 Ensembl | MGI Sequence Detail 4616 Not Applicable  
    polypeptide ENSMUSP00000038135 Ensembl | MGI Sequence Detail 1384 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      10 Sequences
    • Protein Ontology
      PR:000006474 ATP-dependent RNA helicase A
      (term hierarchy)
    • PDB
      1UIL, 1WHQ, 2RS6, 2RS7
    • EC
      3.6.4.13
    • InterPro Domains
      IPR011709 DEAD-box helicase, OB fold
      IPR011545 DEAD/DEAH-box helicase domain
      IPR044447 DHX9, DEXH-box helicase domain
      IPR044445 DHX9, first double-stranded RNA binding domain
      IPR044446 DHX9, second double-stranded RNA binding domain
      IPR002464 DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site
      IPR014720 Double-stranded RNA-binding domain
      IPR007502 Helicase-associated domain
      IPR048333 Helicase associated domain (HA2), winged-helix domain
      IPR001650 Helicase, C-terminal domain-like
      IPR014001 Helicase superfamily 1/2, ATP-binding domain
      IPR027417 P-loop containing nucleoside triphosphate hydrolase
    • GlyGen
      O70133 4 sites, 3 N-linked glycans (2 sites), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 74
      Genomic 3
      cDNA 70
      Primer pair 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-37216, MGI:2138215
    References
    more
    • Summaries
      All 80
      Developmental Gene Expression 6
      Gene Ontology 16
      Phenotypes 23
    • Earliest
      J:45144 Miazek A, et al., Identification of a T cell lineage-specific RNA/DNA helicase and its cell surface expression during intrathymic education of alphabeta and gammadelta T cells. Eur J Immunol. 1997 Dec;27(12):3269-82
    • Latest
      J:382687 Shi M, et al., DHX9 sustains hematopoietic stem cell function in cooperation with H3 acetylation. Stem Cell Reports. 2026 Mar 10;21(3):102794
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory