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Neurod4 Gene Detail
Summary
  • Symbol
    Neurod4
  • Name
    neurogenic differentiation 4
  • Synonyms
    Atoh3, bHLHa4, Math3, MATH-3
  • Feature Type
    protein coding gene
  • IDs
    MGI:108055
    NCBI Gene: 11923
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:130104021-130116109 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 77.81 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    259 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_108055
 protein coding gene Chr10:130104021-130116123 (-)
129S1/SvImJ ENSMUSG00200013001
 protein coding gene Chr10:126462473-126474566 (-)
A/J ENSMUSG00195013789
 protein coding gene Chr10:126931637-126943742 (-)
AKR/J ENSMUSG00220006164
 protein coding gene Chr10:126525332-126537453 (-)
BALB/cJ ENSMUSG00180011031
 protein coding gene Chr10:126916642-126928744 (-)
C3H/HeJ ENSMUSG00175005514
 protein coding gene Chr10:126906031-126918150 (-)
C57BL/6NJ ENSMUSG00215012717
 protein coding gene Chr10:126522781-126534869 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016002
 protein coding gene Chr10:122533470-122544077 (-)
CAST/EiJ ENSTCUG00005037745
 protein coding gene Chr10:125880613-125892656 (-)
CBA/J ENSMUSG00210007580
 protein coding gene Chr10:126730337-126742462 (-)
DBA/2J ENSMUSG00185025862
 protein coding gene Chr10:126889679-126901772 (-)
FVB/NJ ENSMUSG00205013005
 protein coding gene Chr10:126133847-126145963 (-)
JF1/MsJ ENSUMUG00000032945
 protein coding gene Chr10:128206142-128218253 (-)
LP/J ENSMUSG00230032914
 protein coding gene Chr10:128823986-128836068 (-)
NOD/ShiLtJ ENSMUSG00190014654
 protein coding gene Chr10:126947648-126959739 (-)
NZO/HlLtJ ENSMUSG00225012766
 protein coding gene Chr10:133014288-133026391 (-)
PWK/PhJ ENSLUMG00010010091
 protein coding gene Chr10:126662458-126674517 (-)
SPRET/EiJ ENSMSPG00010027683
 protein coding gene Chr10:128608916-128620916 (-)
WSB/EiJ ENSIUOG00005007664
 protein coding gene Chr10:126536271-126548425 (-)



Homology
more
  • Human Ortholog
    NEUROD4, neuronal differentiation 4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NEUROD4, neuronal differentiation 4
  • Synonyms
    ATH-3, ATH3, Atoh3, bHLHa4, MATH-3, MATH3
  • Links
    NCBI Gene ID: 58158
    UniProt: Q9HD90

  • Chr Location
    12q13.2; chr12:55019974-55030017 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotypes from 1 allele in 1 genetic background
    26 phenotypes from multigenic genotypes
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation exhibit reduced growth, ataxia, and high postnatal mortality. Mutants show impaired postnatal cerebellar development, with thinner inner granular cell and molecular layers.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    30
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1169
  • Tissues
    290
  • cDNA Data
    42
  • Literature Summary
    78
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000048015 Ensembl Gene Model | MGI Sequence Detail 12089 C57BL/6J ±  kb
    transcript ENSMUST00000061571 Ensembl | MGI Sequence Detail 3345 Not Applicable  
    polypeptide ENSMUSP00000051379 Ensembl | MGI Sequence Detail 330 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000011154 neurogenic differentiation factor 4
      (term hierarchy)
    • InterPro Domains
      IPR050359 Basic helix-loop-helix transcription factors
      IPR036638 Helix-loop-helix DNA-binding domain superfamily
      IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
      IPR022575 Neurogenic differentiation factor, domain of unknown function
      IPR016637 Neurogenic differentiation factor NeuroD
    Molecular
    Reagents
    less
    • All nucleic 56
      Genomic 2
      cDNA 43
      Primer pair 7
      Other 4
      Antibodies 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-37091, MGI:2143684
    References
    more
    • Summaries
      All 118
      Developmental Gene Expression 78
      Gene Ontology 10
      Phenotypes 12
    • Earliest
      J:36536 Isaka F, et al., Genetic mapping of four mouse bHLH genes related to Drosophila proneural gene atonal. Genomics. 1996 Nov 1;37(3):400-2
    • Latest
      J:372018 Li W, et al., Kin17 promotes rDNA transcription, ribosomal biogenesis, and cortical lamination. EMBO Rep. 2025 Sep;26(17):4283-4311
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory