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Alppl2 Gene Detail
Summary
  • Symbol
    Alppl2
  • Name
    alkaline phosphatase, placental-like 2
  • Synonyms
    Akp5, D1Ertd816e
  • Feature Type
    protein coding gene
  • IDs
    MGI:108009
    NCBI Gene: 11650
  • Alliance
    gene page
Location &
Maps
more
  • Sequence Map
    Chr1:87014416-87017650 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 44.05 cM, cytoband C5
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    47 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_108009
 protein coding gene Chr1:87014412-87023656 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016254
 protein coding gene Chr1:88417219-88420453 (-)
A/J MGP_AJ_G0016235
 protein coding gene Chr1:85117735-85120969 (-)
AKR/J MGP_AKRJ_G0016196
 protein coding gene Chr1:87629231-87632465 (-)
BALB/cJ MGP_BALBcJ_G0016192
 protein coding gene Chr1:85233691-85236925 (-)
C3H/HeJ MGP_C3HHeJ_G0016020
 protein coding gene Chr1:87887844-87891078 (-)
C57BL/6NJ MGP_C57BL6NJ_G0016648
 protein coding gene Chr1:91770114-91773348 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014370
 protein coding gene Chr1:79571378-79574579 (-)
CAST/EiJ MGP_CASTEiJ_G0015605
 protein coding gene Chr1:87092811-87096041 (-)
CBA/J MGP_CBAJ_G0015996
 protein coding gene Chr1:94627860-94631094 (-)
DBA/2J MGP_DBA2J_G0016099
 protein coding gene Chr1:84420948-84424182 (-)
FVB/NJ MGP_FVBNJ_G0016098
 protein coding gene Chr1:83482922-83487132 (-)
LP/J MGP_LPJ_G0016170
 protein coding gene Chr1:89488521-89491755 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016124
 protein coding gene Chr1:97915718-97918952 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0016691
 protein coding gene Chr1:87730429-87733663 (-)
PWK/PhJ MGP_PWKPhJ_G0015392
 protein coding gene Chr1:83718140-83721382 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015172
 protein coding gene Chr1:86662578-86665840 (-)
WSB/EiJ MGP_WSBEiJ_G0015669
 protein coding gene Chr1:87397815-87401049 (-)



Homology
more
  • Human Ortholog
    ALPG, alkaline phosphatase, germ cell
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ALPG, alkaline phosphatase, germ cell
  • Synonyms
    ALPPL, ALPPL2, GCAP
  • Links
    NCBI Gene ID: 251
    neXtProt AC: NX_P10696
    UniProt: P10696

  • Chr Location
    2q37.1; chr2:232406844-232410714 (+)  GRCh38
  • Human Ortholog
    ALPI, alkaline phosphatase, intestinal
  • Synonyms
    IAP
  • Links
    NCBI Gene ID: 248
    neXtProt AC: NX_P09923
    UniProt: P09923

  • Chr Location
    2q37.1; chr2:232456125-232460753 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human ALPI associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 1 allele in 2 genetic backgrounds
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit strain background-dependent differences in the timing of preimplantation cleavage and development, embryo survival, gestational length and litter size.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    11
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    822
  • Tissues
    110
  • cDNA Data
    128
  • Literature Summary
    6
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000026246 Ensembl Gene Model | MGI Sequence Detail 3235 C57BL/6J ±  kb
transcript ENSMUST00000188310 Ensembl | MGI Sequence Detail 2016 Not Applicable  
polypeptide ENSMUSP00000139887 Ensembl | MGI Sequence Detail 529 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 133
    Genomic 2
    cDNA 128
    Primer pair 3

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-37043, MGI:1289312, MGI:2138659
References
more
  • Summaries
    All 44
    Developmental Gene Expression 6
    Gene Ontology 5
    Phenotypes 10
  • Earliest
    J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
  • Latest
    J:279777 Arno B, et al., TNAP limits TGF-beta-dependent cardiac and skeletal muscle fibrosis by inactivating the SMAD2/3 transcription factors. J Cell Sci. 2019 Aug 8;132(15):jcs234948
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory