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Serpina5 Gene Detail
Summary
  • Symbol
    Serpina5
  • Name
    serine (or cysteine) peptidase inhibitor, clade A, member 5
  • Synonyms
    alpha-1 antiproteinase, antitrypsin, PAI-3, Pci
  • Feature Type
    protein coding gene
  • IDs
    MGI:107817
    NCBI Gene: 268591
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:104067372-104072396 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 53.30 cM, cytoband F1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    104 from dbSNP Build 142
  • Strain Annotations
    16
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107817
 protein coding gene Chr12:104065572-104072397 (+)
129S1/SvImJ MGP_129S1SvImJ_G0020066
 protein coding gene Chr12:105858611-105863616 (+)
A/J MGP_AJ_G0020020
 protein coding gene Chr12:101866968-101871992 (+)
AKR/J no annotation
BALB/cJ MGP_BALBcJ_G0020006
 protein coding gene Chr12:102156409-102167060 (+)
C3H/HeJ MGP_C3HHeJ_G0019810
 protein coding gene Chr12:105233503-105238572 (+)
C57BL/6NJ MGP_C57BL6NJ_G0020453
 protein coding gene Chr12:109171293-109176338 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0018069
 protein coding gene Chr12:98533709-98548217 (+)
CAST/EiJ MGP_CASTEiJ_G0019350
 protein coding gene Chr12:99967896-99979901 (+)
CBA/J no annotation
DBA/2J MGP_DBA2J_G0019893
 protein coding gene Chr12:101278681-101287444 (+)
FVB/NJ MGP_FVBNJ_G0019879
 protein coding gene Chr12:100102565-100122548 (+)
LP/J MGP_LPJ_G0019968
 protein coding gene Chr12:105698601-105705024 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019917
 protein coding gene Chr12:116656818-116669515 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0020481
 protein coding gene Chr12:104212192-104217142 (+)
PWK/PhJ MGP_PWKPhJ_G0019114
 protein coding gene Chr12:95847454-95852527 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018914
 protein coding gene Chr12:98413527-98418539 (+)
WSB/EiJ MGP_WSBEiJ_G0019409
 protein coding gene Chr12:105062590-105072280 (+)



Homology
more
  • Human Ortholog
    SERPINA5, serpin family A member 5
  • Vertebrate Orthologs
    7
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SERPINA5, serpin family A member 5
  • Synonyms
    PAI3, PAI-3, PCI, PCI-B, PLANH3, PROCI
  • Links
    NCBI Gene ID: 5104
    neXtProt AC: NX_P05154
    UniProt: P05154

  • Chr Location
    14q32.13; chr14:94561442-94593118 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    12 phenotypes from 2 alleles in 2 genetic backgrounds
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene are phenotypically normal with the exception that males are infertile.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    53
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    766
  • Tissues
    54
  • cDNA Data
    10
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000041550 Ensembl Gene Model | MGI Sequence Detail 5025 C57BL/6J ±  kb
    transcript ENSMUST00000021495 Ensembl | MGI Sequence Detail 2162 Not Applicable  
    polypeptide ENSMUSP00000021495 Ensembl | MGI Sequence Detail 405 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 13
      Genomic 3
      cDNA 10

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-36394
    References
    more
    • Summaries
      All 40
      Developmental Gene Expression 3
      Gene Ontology 7
      Phenotypes 10
    • Earliest
      J:34281 Zechmeister-Machhart M, et al., Molecular cloning and tissue distribution of mouse protein C inhibitor (PCI). Immunopharmacology. 1996 May;32(1-3):96-8
    • Latest
      J:292644 Whiley PAF, et al., Activin A Determines Steroid Levels and Composition in the Fetal Testis. Endocrinology. 2020 Jul 1;161(7)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory