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Pfkfb1 Gene Detail
Summary
  • Symbol
    Pfkfb1
  • Name
    6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1
  • Synonyms
    PFK-2/FBPase-2 gene A
  • Feature Type
    protein coding gene
  • IDs
    MGI:107816
    NCBI Gene: 18639
  • Alliance
    genome feature page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:149371225-149426874 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 68.46 cM, cytoband F2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    959 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107816
 protein coding gene ChrX:149370441-149426874 (+)
129S1/SvImJ ENSMUSG00200030673
 protein coding gene ChrX:126167046-126222694 (+)
A/J ENSMUSG00195020170
 protein coding gene ChrX:131174939-131224216 (+)
AKR/J ENSMUSG00220033488
 protein coding gene ChrX:123175105-123231902 (+)
BALB/cJ ENSMUSG00180036360
 protein coding gene ChrX:126562768-126612042 (+)
C3H/HeJ ENSMUSG00175029118
 protein coding gene ChrX:131085569-131141216 (+)
C57BL/6NJ ENSMUSG00215019873
 protein coding gene ChrX:126850622-126906275 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0033486
 protein coding gene ChrX:139366929-139412434 (+)
CAST/EiJ ENSTCUG00005034519
 protein coding gene ChrX:128886158-128930077 (+)
CBA/J ENSMUSG00210030598
 protein coding gene ChrX:128562929-128618580 (+)
DBA/2J ENSMUSG00185041693
 protein coding gene ChrX:143384367-143440018 (+)
FVB/NJ ENSMUSG00205015844
 protein coding gene ChrX:127128975-127178246 (+)
JF1/MsJ ENSUMUG00000022787
 protein coding gene ChrX:163605403-163651656 (+)
LP/J ENSMUSG00230030534
 protein coding gene ChrX:150186557-150242207 (+)
NOD/ShiLtJ ENSMUSG00190037075
 protein coding gene ChrX:127679576-127728849 (+)
NZO/HlLtJ ENSMUSG00225041559
 protein coding gene ChrX:153683364-153739013 (+)
PWK/PhJ ENSLUMG00010030326
 protein coding gene ChrX:125139942-125186219 (+)
SPRET/EiJ ENSMSPG00010035302
 protein coding gene ChrX:129977827-130024020 (+)
WSB/EiJ ENSIUOG00005037631
 protein coding gene ChrX:128157814-128213474 (+)



Homology
more
  • Human Ortholog
    PFKFB1, 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PFKFB1, 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1
  • Synonyms
    F6PK, HL2K, PFRX
  • Links
    NCBI Gene ID: 5207
    UniProt: P16118

  • Chr Location
    Xp11.21; chrX:54931434-54998789 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    51
  • GO References
    16
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    695
  • Tissues
    97
  • cDNA Data
    23
  • Literature Summary
    3
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000025271 Ensembl Gene Model | MGI Sequence Detail 55650 C57BL/6J ±  kb
transcript ENSMUST00000112713 Ensembl | MGI Sequence Detail 1872 Not Applicable  
polypeptide ENSMUSP00000108333 Ensembl | MGI Sequence Detail 471 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 25
    cDNA 24
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-36393
References
more
  • Summaries
    All 51
    Developmental Gene Expression 3
    Gene Ontology 16
    Phenotypes 11
  • Earliest
    J:331947 Van Schaftingen E, et al., Inhibition of fructose-1,6-bisphosphatase by fructose 2,6-biphosphate. Proc Natl Acad Sci U S A. 1981 May;78(5):2861-3
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory