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Dync1i2 Gene Detail
Summary
  • Symbol
    Dync1i2
  • Name
    dynein cytoplasmic 1 intermediate chain 2
  • Synonyms
    3110079H08Rik, Dncic2
  • Feature Type
    protein coding gene
  • IDs
    MGI:107750
    NCBI Gene: 13427
  • Alliance
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:71042050-71093647 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 2, 42.38 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    389 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107750
protein coding gene Chr2:71041999-71093647 (+)
129S1/SvImJ MGP_129S1SvImJ_G0025820
protein coding gene Chr2:71298511-71353118 (+)
A/J MGP_AJ_G0025797
protein coding gene Chr2:68515773-68567990 (+)
AKR/J MGP_AKRJ_G0025766
protein coding gene Chr2:70385049-70439184 (+)
BALB/cJ MGP_BALBcJ_G0025792
protein coding gene Chr2:68706600-68758119 (+)
C3H/HeJ MGP_C3HHeJ_G0025552
protein coding gene Chr2:70600591-70653322 (+)
C57BL/6NJ MGP_C57BL6NJ_G0026239
protein coding gene Chr2:73447400-73504274 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023642
protein coding gene Chr2:65748878-65799898 (+)
CAST/EiJ MGP_CASTEiJ_G0025016
protein coding gene Chr2:70786676-70843590 (+)
CBA/J MGP_CBAJ_G0025532
protein coding gene Chr2:76167055-76226144 (+)
DBA/2J MGP_DBA2J_G0025663
protein coding gene Chr2:68154557-68207930 (+)
FVB/NJ MGP_FVBNJ_G0025626
protein coding gene Chr2:67539143-67590888 (+)
LP/J MGP_LPJ_G0025752
protein coding gene Chr2:71157074-71214319 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0025655
protein coding gene Chr2:78141493-78193511 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0026296
protein coding gene Chr2:70485974-70541464 (+)
PWK/PhJ MGP_PWKPhJ_G0024757
protein coding gene Chr2:68016080-68070553 (+)
SPRET/EiJ MGP_SPRETEiJ_G0024564
protein coding gene Chr2:70681672-70734767 (+)
WSB/EiJ MGP_WSBEiJ_G0025084
protein coding gene Chr2:70918755-70972915 (+)



Homology
more
  • Human Ortholog
    DYNC1I2, dynein cytoplasmic 1 intermediate chain 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DYNC1I2, dynein cytoplasmic 1 intermediate chain 2
  • Synonyms
    DIC74, DNCI2, IC2, NEDMIBA
  • Links
    NCBI Gene ID: 1781
    neXtProt AC: NX_Q13409
    UniProt: Q13409

  • Chr Location
    2q31.1; chr2:171687409-171750158 (+)  GRCh38

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 2 alleles in 2 genetic backgrounds
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for an ENU-induced allele exhibit a trend towards slight locomotor deficit.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000027012 Ensembl Gene Model | MGI Sequence Detail 51598 C57BL/6J ±  kb
    transcript ENSMUST00000112140 Ensembl | MGI Sequence Detail 2573 Not Applicable  
    polypeptide ENSMUSP00000107768 Ensembl | MGI Sequence Detail 638 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 210
      cDNA 207
      Primer pair 2
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-36326, MGI:1925763, MGI:2139394
    References
    more
    • Summaries
      All 59
      Developmental Gene Expression 13
      Gene Ontology 7
      Phenotypes 14
    • Earliest
      J:34934 Vaughan KT, et al., Multiple mouse chromosomal loci for dynein-based motility. Genomics. 1996 Aug 15;36(1):29-38
    • Latest
      J:334512 He S, et al., Distinct dynein complexes defined by DYNLRB1 and DYNLRB2 regulate mitotic and male meiotic spindle bipolarity. Nat Commun. 2023 Mar 27;14(1):1715

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    03/19/2024
    MGI 6.23
    The Jackson Laboratory