About   Help   FAQ
Usp17le Gene Detail
Summary
  • Symbol
    Usp17le
  • Name
    ubiquitin specific peptidase 17-like E
  • Synonyms
    Dub3, Gm6596
  • Feature Type
    protein coding gene
  • IDs
    MGI:107697
    NCBI Gene: 625530
  • Alliance
    gene page
Location &
Maps
more
  • Sequence Map
    Chr7:104417256-104426677 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 55.69 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    39 from dbSNP Build 142
  • Strain Annotations
    16
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107697
 protein coding gene Chr7:104417168-104426677 (-)
129S1/SvImJ MGP_129S1SvImJ_G0032657
 protein coding gene Chr7:106554081-106555875 (+)
A/J MGP_AJ_G0032704
 protein coding gene Chr7:105216382-105219864 (+)
AKR/J MGP_AKRJ_G0032637
 protein coding gene Chr7:107783391-107787127 (-)
BALB/cJ MGP_BALBcJ_G0032712
 protein coding gene Chr7:104796783-104799159 (-)
C3H/HeJ no annotation
C57BL/6NJ MGP_C57BL6NJ_G0033214
 protein coding gene Chr7:112183685-112185212 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030204
 protein coding gene Chr7:107276477-107279578 (+)
CAST/EiJ MGP_CASTEiJ_G0031753
 protein coding gene Chr7:99755336-99759212 (-)
CBA/J MGP_CBAJ_G0032396
 protein coding gene Chr7:115927652-115930348 (-)
DBA/2J MGP_DBA2J_G0032547
 protein coding gene Chr7:103512537-103515879 (+)
FVB/NJ MGP_FVBNJ_G0032499
 protein coding gene Chr7:103139552-103241649 (-)
LP/J MGP_LPJ_G0032638
 protein coding gene Chr7:109245026-109246392 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0032533
 protein coding gene Chr7:117417114-117418687 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0033236
 protein coding gene Chr7:106924912-106926491 (-)
PWK/PhJ MGP_PWKPhJ_G0031395
 protein coding gene Chr7:95012094-95013860 (-)
SPRET/EiJ no annotation
WSB/EiJ MGP_WSBEiJ_G0031867
 protein coding gene Chr7:107603308-107613254 (-)



Homology
more
  • Human Ortholog
    USP17L1, ubiquitin specific peptidase 17 like family member 1
  • Vertebrate Orthologs
    29
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    USP17L1, ubiquitin specific peptidase 17 like family member 1
  • Synonyms
    USP17L1P
  • Links
    NCBI Gene ID: 401447
    neXtProt AC: NX_Q7RTZ2
    UniProt: Q7RTZ2

  • Chr Location
    8p23.1; chr8:7332387-7333979 (+)  GRCh38
  • Human Ortholog
    USP17L10, ubiquitin specific peptidase 17 like family member 10
  • Links
    NCBI Gene ID: 100287144
    neXtProt AC: NX_C9JJH3
    UniProt: C9JJH3

  • Chr Location
    chr4:9210657-9212249 (+)  GRCh38
  • Human Ortholog
    USP17L11, ubiquitin specific peptidase 17 like family member 11
  • Links
    NCBI Gene ID: 100287178
    neXtProt AC: NX_C9JVI0
    UniProt: C9JVI0

  • Chr Location
    chr4:9215405-9216997 (+)  GRCh38
  • Human Ortholog
    USP17L12, ubiquitin specific peptidase 17 like family member 12
  • Links
    NCBI Gene ID: 100287205
    neXtProt AC: NX_C9JPN9
    UniProt: C9JPN9

  • Chr Location
    chr4:9220152-9221744 (+)  GRCh38
  • Human Ortholog
    USP17L13, ubiquitin specific peptidase 17 like family member 13
  • Links
    NCBI Gene ID: 100287238
    neXtProt AC: NX_C9JLJ4
    UniProt: C9JLJ4

  • Chr Location
    chr4:9224896-9226488 (+)  GRCh38
  • Human Ortholog
    USP17L15, ubiquitin specific peptidase 17 like family member 15
  • Links
    NCBI Gene ID: 100288520
    UniProt: C9J2P7

  • Chr Location
    chr4:9234385-9236046 (+)  GRCh38
  • Human Ortholog
    USP17L17, ubiquitin specific peptidase 17 like family member 17
  • Links
    NCBI Gene ID: 100287327
    neXtProt AC: NX_D6RBQ6
    UniProt: D6RBQ6

  • Chr Location
    chr4:9243879-9245471 (+)  GRCh38
  • Human Ortholog
    USP17L18, ubiquitin specific peptidase 17 like family member 18
  • Links
    NCBI Gene ID: 100287364
    neXtProt AC: NX_D6R9N7
    UniProt: D6R9N7

  • Chr Location
    chr4:9248630-9250222 (+)  GRCh38
  • Human Ortholog
    USP17L19, ubiquitin specific peptidase 17 like family member 19
  • Links
    NCBI Gene ID: 100287404
    neXtProt AC: NX_D6RCP7
    UniProt: D6RCP7

  • Chr Location
    chr4:9253378-9254970 (+)  GRCh38
  • Human Ortholog
    USP17L2, ubiquitin specific peptidase 17 like family member 2
  • Synonyms
    DUB3, DUB-3, USP17
  • Links
    NCBI Gene ID: 377630
    neXtProt AC: NX_Q6R6M4
    UniProt: Q6R6M4

  • Chr Location
    8p23.1; chr8:12136435-12138849 (-)  GRCh38
  • Human Ortholog
    USP17L20, ubiquitin specific peptidase 17 like family member 20
  • Links
    NCBI Gene ID: 100287441
    neXtProt AC: NX_D6RJB6
    UniProt: D6RJB6

  • Chr Location
    chr4:9258124-9259716 (+)  GRCh38
  • Human Ortholog
    USP17L21, ubiquitin specific peptidase 17 like family member 21
  • Links
    NCBI Gene ID: 100287478
    neXtProt AC: NX_D6R901
    UniProt: D6R901

  • Chr Location
    chr4:9262872-9264464 (+)  GRCh38
  • Human Ortholog
    USP17L22, ubiquitin specific peptidase 17 like family member 22
  • Links
    NCBI Gene ID: 100287513
    neXtProt AC: NX_D6RA61
    UniProt: D6RA61

  • Chr Location
    chr4:9267619-9269211 (+)  GRCh38
  • Human Ortholog
    USP17L23, ubiquitin specific peptidase 17 like family member 23
  • Links
    NCBI Gene ID: 101241878
    UniProt: D6RBM5

  • Chr Location
    4p16.1; chr4:9272364-9272914 (+)  GRCh38
  • Human Ortholog
    USP17L24, ubiquitin specific peptidase 17 like family member 24
  • Synonyms
    USP17L25, USP17L26, USP17L27, USP17L28, USP17L29, USP17L30
  • Links
    NCBI Gene ID: 728369
    neXtProt AC: NX_Q0WX57
    UniProt: Q0WX57

  • Chr Location
    4p16.1; chr4:9325165-9326757 (+)  GRCh38
  • Human Ortholog
    USP17L25, ubiquitin specific peptidase 17 like family member 25
  • Links
    NCBI Gene ID: 728373
    neXtProt AC: NX_Q0WX57

  • Chr Location
    4p16.1; chr4:9329911-9331503 (+)  GRCh38
  • Human Ortholog
    USP17L26, ubiquitin specific peptidase 17 like family member 26
  • Links
    NCBI Gene ID: 728379
    neXtProt AC: NX_Q0WX57

  • Chr Location
    4p16.1; chr4:9334658-9336250 (+)  GRCh38
  • Human Ortholog
    USP17L27, ubiquitin specific peptidase 17 like family member 27
  • Links
    NCBI Gene ID: 728393
    neXtProt AC: NX_Q0WX57

  • Chr Location
    4p16.1; chr4:9344148-9345740 (+)  GRCh38
  • Human Ortholog
    USP17L28, ubiquitin specific peptidase 17 like family member 28
  • Links
    NCBI Gene ID: 728400
    neXtProt AC: NX_Q0WX57

  • Chr Location
    4p16.1; chr4:9348893-9350485 (+)  GRCh38
  • Human Ortholog
    USP17L29, ubiquitin specific peptidase 17 like family member 29
  • Links
    NCBI Gene ID: 728405
    neXtProt AC: NX_Q0WX57

  • Chr Location
    4p16.1; chr4:9353638-9355230 (+)  GRCh38
  • Human Ortholog
    USP17L3, ubiquitin specific peptidase 17 like family member 3
  • Synonyms
    USP17B, USP17F
  • Links
    NCBI Gene ID: 645836
    neXtProt AC: NX_A6NCW0
    UniProt: A6NCW0

  • Chr Location
    8p23.1; chr8:7976393-7977985 (-)  GRCh38
  • Human Ortholog
    USP17L30, ubiquitin specific peptidase 17 like family member 30
  • Links
    NCBI Gene ID: 728419
    neXtProt AC: NX_Q0WX57

  • Chr Location
    4p16.1; chr4:9363129-9364721 (+)  GRCh38
  • Human Ortholog
    USP17L4, ubiquitin specific peptidase 17 like family member 4
  • Links
    NCBI Gene ID: 645402
    neXtProt AC: NX_A6NCW7
    UniProt: A6NCW7

  • Chr Location
    8p23.1; chr8:7337115-7338707 (+)  GRCh38
  • Human Ortholog
    USP17L5, ubiquitin specific peptidase 17 like family member 5
  • Links
    NCBI Gene ID: 728386
    neXtProt AC: NX_A8MUK1
    UniProt: A8MUK1

  • Chr Location
    4p16.1; chr4:9339403-9340995 (+)  GRCh38
  • Human Ortholog
    USP17L6P, ubiquitin specific peptidase 17 like family member 6, pseudogene
  • Synonyms
    DUB4, USP17L6, vDUB4
  • Links
    NCBI Gene ID: 391622
    UniProt: Q6QN14

  • Chr Location
    4p16.1; chr4:9367874-9369070 (+)  GRCh38
  • Human Ortholog
    USP17L7, ubiquitin specific peptidase 17 like family member 7
  • Links
    NCBI Gene ID: 392197
    neXtProt AC: NX_P0C7H9
    UniProt: P0C7H9

  • Chr Location
    8p23.1; chr8:12132417-12134099 (-)  GRCh38
  • Human Ortholog
    USP17L8, ubiquitin specific peptidase 17 like family member 8
  • Synonyms
    USP17L10
  • Links
    NCBI Gene ID: 392188
    neXtProt AC: NX_P0C7I0
    UniProt: P0C7I0

  • Chr Location
    8p23.1; chr8:7971661-7973253 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotype references
  • All Mutations and Alleles
    2
  • Chemically induced (other)
    1
  • Radiation induced
    1
  • Genomic Mutations
    2 involving Usp17le
  • Incidental Mutations
    APF
  • Find Mice (IMSR)
    20 strains or lines available
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    38
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000043073 Ensembl Gene Model | MGI Sequence Detail 9422 C57BL/6J ±  kb
transcript ENSMUST00000211384 Ensembl | MGI Sequence Detail 1885 Not Applicable  
polypeptide ENSMUSP00000147776 Ensembl | MGI Sequence Detail 540 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    3 Sequences
  • EC
    3.4.19.12
  • InterPro Domains
    IPR038765 Papain-like cysteine peptidase superfamily
    IPR001394 Peptidase C19, ubiquitin carboxyl-terminal hydrolase
    IPR018200 Ubiquitin specific protease, conserved site
    IPR028889 Ubiquitin specific protease domain
Molecular
Reagents
less
  • All nucleic 1
    Genomic 1
Other
Accession IDs
less
MGD-MRK-36273, MGI:3643640
References
more
  • Summaries
    All 30
    Gene Ontology 5
    Phenotypes 9
  • Earliest
    J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
  • Latest
    J:206170 van der Laan S, et al., High Dub3 expression in mouse ESCs couples the G1/S checkpoint to pluripotency. Mol Cell. 2013 Nov 7;52(3):366-79
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
04/09/2024
MGI 6.23 		The Jackson Laboratory