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Rtn2 Gene Detail
Summary
  • Symbol
    Rtn2
  • Name
    reticulon 2 (Z-band associated protein)
  • Synonyms
    Nspl1
  • Feature Type
    protein coding gene
  • IDs
    MGI:107612
    NCBI Gene: 20167
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:19016549-19030085 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 9.54 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    99 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107612
 protein coding gene Chr7:19016549-19030089 (+)
129S1/SvImJ MGP_129S1SvImJ_G0031769
 protein coding gene Chr7:17271628-17290797 (+)
A/J MGP_AJ_G0031745
 protein coding gene Chr7:16925690-16939115 (+)
AKR/J MGP_AKRJ_G0031671
 protein coding gene Chr7:17386838-17401942 (+)
BALB/cJ MGP_BALBcJ_G0031750
 protein coding gene Chr7:17128416-17141993 (+)
C3H/HeJ MGP_C3HHeJ_G0031472
 protein coding gene Chr7:17653239-17669758 (+)
C57BL/6NJ MGP_C57BL6NJ_G0032216
 protein coding gene Chr7:18139919-18153904 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029282
 protein coding gene Chr7:18572658-18586990 (+)
CAST/EiJ MGP_CASTEiJ_G0030815
 protein coding gene Chr7:14060065-14071159 (+)
CBA/J MGP_CBAJ_G0031434
 protein coding gene Chr7:18810432-18824295 (+)
DBA/2J MGP_DBA2J_G0031589
 protein coding gene Chr7:16866284-16881233 (+)
FVB/NJ MGP_FVBNJ_G0031541
 protein coding gene Chr7:16728340-16742857 (+)
LP/J MGP_LPJ_G0031672
 protein coding gene Chr7:17592743-17606656 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0031577
 protein coding gene Chr7:18660137-18676319 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0032244
 protein coding gene Chr7:16994989-17009588 (+)
PWK/PhJ MGP_PWKPhJ_G0030539
 protein coding gene Chr7:13954863-13970859 (+)
SPRET/EiJ MGP_SPRETEiJ_G0030366
 protein coding gene Chr7:11710289-11724814 (+)
WSB/EiJ MGP_WSBEiJ_G0030915
 protein coding gene Chr7:17213655-17228942 (+)



Homology
more
  • Human Ortholog
    RTN2, reticulon 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RTN2, reticulon 2
  • Synonyms
    NSP2, NSPL1, NSPLI, SPG12
  • Links
    NCBI Gene ID: 6253
    neXtProt AC: NX_O75298
    UniProt: O75298

  • Chr Location
    19q13.32; chr19:45485294-45497055 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human RTN2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    4 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice heterozygous and homozygous for an allele disrupting the skeletal isoform exhibit abollished or severely impaired glucose uptake in skeletal muscle.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    15
  • GO References
    8
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    972
  • Tissues
    244
  • cDNA Data
    57
  • Literature Summary
    10
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000030401 Ensembl Gene Model | MGI Sequence Detail 13537 C57BL/6J ±  kb
    transcript ENSMUST00000032559 Ensembl | MGI Sequence Detail 1990 Not Applicable  
    polypeptide ENSMUSP00000032559 Ensembl | MGI Sequence Detail 471 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 68
      Genomic 2
      cDNA 59
      Primer pair 6
      Other 1

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGD-MRK-36186
    References
    more
    • Summaries
      All 41
      Developmental Gene Expression 10
      Gene Ontology 8
      Phenotypes 4
    • Earliest
      J:2957 Lazo PS, et al., Structure and mapping of the fosB gene. FosB downregulates the activity of the fosB promoter. Nucleic Acids Res. 1992 Jan 25;20(2):343-50
    • Latest
      J:343450 Zhou J, et al., Reticulons 1 and 3 are essential for axonal growth and synaptic maintenance associated with intellectual development. Hum Mol Genet. 2023 Aug 7;32(16):2587-2599
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory