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Epx Gene Detail
Summary
  • Symbol
    Epx
  • Name
    eosinophil peroxidase
  • Synonyms
    EPO
  • Feature Type
    protein coding gene
  • IDs
    MGI:107569
    NCBI Gene: 13861
  • Alliance
    genome feature page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:87754826-87766362 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 52.25 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    142 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107569
 protein coding gene Chr11:87754824-87766362 (-)
129S1/SvImJ ENSMUSG00200020164
 protein coding gene Chr11:84890562-84902072 (-)
A/J ENSMUSG00195008264
 protein coding gene Chr11:84745447-84756958 (-)
AKR/J ENSMUSG00220011305
 protein coding gene Chr11:84945019-84956527 (-)
BALB/cJ ENSMUSG00180010954
 protein coding gene Chr11:84952222-84963730 (-)
C3H/HeJ ENSMUSG00175031301
 protein coding gene Chr11:84892028-84903536 (-)
C57BL/6NJ ENSMUSG00215023726
 protein coding gene Chr11:84530486-84542022 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016940
 protein coding gene Chr11:83086501-83097576 (-)
CAST/EiJ ENSTCUG00005016884
 protein coding gene Chr11:84440640-84452080 (-)
CBA/J ENSMUSG00210034706
 protein coding gene Chr11:84709574-84721080 (-)
DBA/2J ENSMUSG00185019303
 protein coding gene Chr11:85026294-85037802 (-)
FVB/NJ ENSMUSG00205015469
 protein coding gene Chr11:84905202-84916707 (-)
JF1/MsJ ENSUMUG00000017952
 protein coding gene Chr11:85351850-85363395 (-)
LP/J ENSMUSG00230028494
 protein coding gene Chr11:86059385-86070910 (-)
NOD/ShiLtJ ENSMUSG00190018643
 protein coding gene Chr11:85057563-85069071 (-)
NZO/HlLtJ ENSMUSG00225039116
 protein coding gene Chr11:88175350-88186874 (-)
PWK/PhJ ENSLUMG00010031762
 protein coding gene Chr11:84903027-84914598 (-)
SPRET/EiJ ENSMSPG00010022426
 protein coding gene Chr11:85303416-85313762 (-)
WSB/EiJ ENSIUOG00005007768
 protein coding gene Chr11:84864063-84875575 (-)



Homology
more
  • Human Ortholog
    EPX, eosinophil peroxidase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    EPX, eosinophil peroxidase
  • Synonyms
    EPO, EPP, EPXD, EPX-PEN
  • Links
    NCBI Gene ID: 8288
    UniProt: P11678

  • Chr Location
    17q22; chr17:58192726-58205174 (+)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 3 alleles in 3 genetic backgrounds
    1 phenotype from multigenic genotypes
    73 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Targeted deletion of this gene results in ultrastructural changes of the eosinophil secondary granule but does not significantly alter the course of inflammation or development of allergic pulmonary pathologies in an ovalbumin-challenge model of pulmonary inflammation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    27
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    700
  • Tissues
    103
  • cDNA Data
    17
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000052234 Ensembl Gene Model | MGI Sequence Detail 11537 C57BL/6J ±  kb
    transcript ENSMUST00000049768 Ensembl | MGI Sequence Detail 2689 Not Applicable  
    polypeptide ENSMUSP00000050497 Ensembl | MGI Sequence Detail 716 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 21
      Genomic 3
      cDNA 17
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-36141
    References
    more
    • Summaries
      All 106
      Developmental Gene Expression 2
      Diseases 1
      Gene Ontology 10
      Phenotypes 73
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:378486 Yu J, et al., GPR43 in eosinophils suppresses the emergence of pathogenic Siglec-F(hi) neutrophils in allergic airway inflammation in mice. Nat Commun. 2025 Nov 26;16(1):10548
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory