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Sema5a Gene Detail
Summary
  • Symbol
    Sema5a
  • Name
    sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A
  • Synonyms
    9130201M22Rik, M-Sema D, Semaf, semF
  • Feature Type
    protein coding gene
  • IDs
    MGI:107556
    NCBI Gene: 20356
  • Alliance
    genome feature page
  • Transcription Start Sites
    13 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:32244959-32696487 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 13.02 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    14066 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107556
 protein coding gene Chr15:32244956-32696487 (+)
129S1/SvImJ ENSMUSG00200027001
 protein coding gene Chr15:29329110-29789460 (+)
A/J ENSMUSG00195013855
 protein coding gene Chr15:29176955-29622438 (+)
AKR/J ENSMUSG00220023970
 protein coding gene Chr15:29061789-29513501 (+)
BALB/cJ ENSMUSG00180005305
 protein coding gene Chr15:29133670-29579199 (+)
C3H/HeJ ENSMUSG00175004491
 protein coding gene Chr15:29304521-29756584 (+)
C57BL/6NJ ENSMUSG00215004759
 protein coding gene Chr15:29156564-29608204 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019715
 protein coding gene Chr15:27361471-27804896 (+)
CAST/EiJ ENSTCUG00005014928
 protein coding gene Chr15:29233195-29692531 (+)
CBA/J ENSMUSG00210024125
 protein coding gene Chr15:29258182-29710247 (+)
DBA/2J ENSMUSG00185023294
 protein coding gene Chr15:29243699-29695545 (+)
FVB/NJ ENSMUSG00205013106
 protein coding gene Chr15:29134018-29579517 (+)
JF1/MsJ ENSUMUG00000010104
 protein coding gene Chr15:29250575-29708209 (+)
LP/J ENSMUSG00230011071
 protein coding gene Chr15:32728496-33186019 (+)
NOD/ShiLtJ ENSMUSG00190011871
 protein coding gene Chr15:29232535-29683909 (+)
NZO/HlLtJ ENSMUSG00225030706
 protein coding gene Chr15:32938916-33390680 (+)
PWK/PhJ ENSLUMG00010021548
 protein coding gene Chr15:29405393-29866136 (+)
SPRET/EiJ ENSMSPG00010023337
 protein coding gene Chr15:30041923-30399401 (+)
WSB/EiJ ENSIUOG00005020506
 protein coding gene Chr15:29235763-29714239 (+)



Homology
more
  • Human Ortholog
    SEMA5A, semaphorin 5A
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SEMA5A, semaphorin 5A
  • Synonyms
    SEMAF, semF
  • Links
    NCBI Gene ID: 9037
    UniProt: Q13591

  • Chr Location
    5p15.31; chr5:9035033-9546142 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 3 alleles in 3 genetic backgrounds
    11 phenotypes from multigenic genotypes
    22 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for one null mutation die during organogenesis and display defects in branching of cranial vessels. Mice homozygous for another null mutation appear normal.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    54
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1224
  • Tissues
    484
  • cDNA Data
    66
  • Literature Summary
    40
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 20356 NCBI Gene Model | MGI Sequence Detail 451529 C57BL/6J ±  kb
    transcript NM_009154 RefSeq | MGI Sequence Detail 10809 ZRU/MplStud  
    polypeptide Q62217 UniProt | EBI | MGI Sequence Detail 1077 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 82
      cDNA 72
      Primer pair 4
      Other 6
      Antibodies 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-36127, MGI:2146024, MGI:2445048
    References
    more
    • Summaries
      All 97
      Developmental Gene Expression 40
      Gene Ontology 12
      Phenotypes 22
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:375548 Ko SY, et al., Systems consolidation reorganizes hippocampal engram circuitry. Nature. 2025 Jul;643(8072):735-743
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory