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Traf5 Gene Detail
Summary
  • Symbol
    Traf5
  • Name
    TNF receptor-associated factor 5
  • Feature Type
    protein coding gene
  • IDs
    MGI:107548
    NCBI Gene: 22033
  • Alliance
    genome feature page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:191729166-191776868 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 97.11 cM
  • Mapping Data
    7 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1060 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107548
 protein coding gene Chr1:191729164-191776899 (-)
129S1/SvImJ ENSMUSG00200003800
 protein coding gene Chr1:189508325-189555111 (-)
A/J ENSMUSG00195008151
 protein coding gene Chr1:189080631-189129059 (-)
AKR/J ENSMUSG00220004413
 protein coding gene Chr1:188324485-188372913 (-)
BALB/cJ ENSMUSG00180015943
 protein coding gene Chr1:189146070-189194488 (-)
C3H/HeJ ENSMUSG00175021172
 protein coding gene Chr1:189333981-189382403 (-)
C57BL/6NJ ENSMUSG00215013459
 protein coding gene Chr1:188561346-188609774 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015058
 protein coding gene Chr1:181799286-181849556 (-)
CAST/EiJ ENSTCUG00005001995
 protein coding gene Chr1:187116324-187164788 (-)
CBA/J ENSMUSG00210003436
 protein coding gene Chr1:189003379-189050153 (-)
DBA/2J ENSMUSG00185010170
 protein coding gene Chr1:193616650-193663429 (-)
FVB/NJ ENSMUSG00205004267
 protein coding gene Chr1:187992072-188040497 (-)
JF1/MsJ ENSUMUG00000006704
 protein coding gene Chr1:192591895-192639702 (-)
LP/J ENSMUSG00230024529
 protein coding gene Chr1:193144861-193193292 (-)
NOD/ShiLtJ ENSMUSG00190024606
 protein coding gene Chr1:188971896-189020318 (-)
NZO/HlLtJ ENSMUSG00225015398
 protein coding gene Chr1:196897255-196945671 (-)
PWK/PhJ ENSLUMG00010005973
 protein coding gene Chr1:187835606-187882388 (-)
SPRET/EiJ ENSMSPG00010021941
 protein coding gene Chr1:191376134-191422202 (-)
WSB/EiJ ENSIUOG00005004485
 protein coding gene Chr1:188334578-188382994 (-)



Homology
more
  • Human Ortholog
    TRAF5, TNF receptor associated factor 5
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TRAF5, TNF receptor associated factor 5
  • Synonyms
    MGC:39780, RNF84
  • Links
    NCBI Gene ID: 7188
    UniProt: O00463

  • Chr Location
    1q32.3; chr1:211326325-211375036 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    27 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice show defects in lymphocyte activation but are otherwise viable and develop normally.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    47
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    631
  • Tissues
    17
  • cDNA Data
    14
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    • All Sequences
      43
    • RefSeq
      6
    • UniProt
      3
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000026637 Ensembl Gene Model | MGI Sequence Detail 47703 C57BL/6J ±  kb
    transcript ENSMUST00000195815 Ensembl | MGI Sequence Detail 2214 Not Applicable  
    polypeptide ENSMUSP00000141931 Ensembl | MGI Sequence Detail 558 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 15
      cDNA 15

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-36119
    References
    more
    • Summaries
      All 72
      Developmental Gene Expression 2
      Gene Ontology 14
      Phenotypes 27
    • Earliest
      J:33749 Nakano H, et al., TRAF5, an activator of NF-kappaB and putative signal transducer for the lymphotoxin-beta receptor. J Biol Chem. 1996 Jun 21;271(25):14661-4
    • Latest
      J:376034 Hikosaka-Kuniishi M, et al., The Role of TNF Receptor-Associated Factor 5 in the Formation of Germinal Centers by B Cells During the Primary Phase of the Immune Response in Mice. Int J Mol Sci. 2024 Nov 17;25(22)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory