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Ereg Gene Detail
Summary
  • Symbol
    Ereg
  • Name
    epiregulin
  • Synonyms
    EPR
  • Feature Type
    protein coding gene
  • IDs
    MGI:107508
    NCBI Gene: 13874
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:91222481-91241505 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 44.78 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    620 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107508
 protein coding gene Chr5:91222476-91241508 (+)
129S1/SvImJ ENSMUSG00200007203
 protein coding gene Chr5:86951270-86969491 (+)
A/J ENSMUSG00195024593
 protein coding gene Chr5:86123448-86142473 (+)
AKR/J ENSMUSG00220011906
 protein coding gene Chr5:86249333-86267568 (+)
BALB/cJ ENSMUSG00180022293
 protein coding gene Chr5:85963279-85981508 (+)
C3H/HeJ ENSMUSG00175042384
 protein coding gene Chr5:88058896-88077123 (+)
C57BL/6NJ ENSMUSG00215017184
 protein coding gene Chr5:86822579-86841605 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027401
 protein coding gene Chr5:84213837-84232265 (+)
CAST/EiJ ENSTCUG00005036598
 protein coding gene Chr5:85709101-85728045 (+)
CBA/J ENSMUSG00210005724
 protein coding gene Chr5:86858665-86876896 (+)
DBA/2J ENSMUSG00185037430
 protein coding gene Chr5:88779599-88797838 (+)
FVB/NJ ENSMUSG00205022490
 protein coding gene Chr5:85679485-85697722 (+)
JF1/MsJ ENSUMUG00000036074
 protein coding gene Chr5:93065432-93083820 (+)
LP/J no annotation
NOD/ShiLtJ ENSMUSG00190027079
 protein coding gene Chr5:85741144-85759383 (+)
NZO/HlLtJ no annotation
PWK/PhJ ENSLUMG00010027555
 protein coding gene Chr5:85738045-85756443 (+)
SPRET/EiJ ENSMSPG00010034415
 protein coding gene Chr5:88118692-88135459 (+)
WSB/EiJ ENSIUOG00005029051
 protein coding gene Chr5:88751464-88769679 (+)



Homology
more
  • Human Ortholog
    EREG, epiregulin
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    EREG, epiregulin
  • Synonyms
    Ep, EPR, ER
  • Links
    NCBI Gene ID: 2069
    UniProt: O14944

  • Chr Location
    4q13.3; chr4:74365145-74388749 (+)  GRCh38
Human Diseases
more
  • Diseases
    3 with human EREG associations

Human Disease Mouse Models
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 2 alleles in 2 genetic backgrounds
    4 phenotypes from multigenic genotypes
    1 images
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice for one allele develop chronic dermatitis. Homozygous null mice for another allele display increased sensitivity to dextran sulfate sodium.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    119
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    632
  • Tissues
    25
  • cDNA Data
    16
  • Literature Summary
    16
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000029377 Ensembl Gene Model | MGI Sequence Detail 19025 C57BL/6J ±  kb
    transcript ENSMUST00000031324 Ensembl | MGI Sequence Detail 4128 Not Applicable  
    polypeptide ENSMUSP00000031324 Ensembl | MGI Sequence Detail 162 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 20
      cDNA 17
      Primer pair 3
      Antibodies 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-36078
    References
    more
    • Summaries
      All 98
      Developmental Gene Expression 16
      Gene Ontology 14
      Phenotypes 21
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:377110 Pham V, et al., IRF6 regulates adherens junction proteins and inflammatory cytokines in salivary acinar cells and its expression is elevated in Sjgren's syndrome. Arch Oral Biol. 2025 Oct;178:106348
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/15/2026
    MGI 6.29     		The Jackson Laboratory