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Mzf1 Gene Detail
Summary
  • Symbol
    Mzf1
  • Name
    myeloid zinc finger 1
  • Synonyms
    Mzf2, Zfp121, Zfp98, Znf42
Location &
Maps
more
  • Sequence Map
    Chr7:12776230-12788691 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 7.73 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    375 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107457
 protein coding gene Chr7:12776230-12792244 (-)
129S1/SvImJ ENSMUSG00200039646
 protein coding gene Chr7:6817490-6829954 (-)
A/J ENSMUSG00195047012
 protein coding gene Chr7:6502048-6514531 (-)
AKR/J ENSMUSG00220020936
 protein coding gene Chr7:5984498-5997000 (-)
BALB/cJ ENSMUSG00180047788
 protein coding gene Chr7:6425161-6437616 (-)
C3H/HeJ ENSMUSG00175036560
 protein coding gene Chr7:6870844-6883309 (-)
C57BL/6NJ ENSMUSG00215043418
 protein coding gene Chr7:7098486-7110947 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029201
 protein coding gene Chr7:11889406-11901985 (-)
CAST/EiJ ENSTCUG00005027727
 protein coding gene Chr7:6579464-6591923 (-)
CBA/J ENSMUSG00210046146
 protein coding gene Chr7:6140599-6153062 (-)
DBA/2J ENSMUSG00185034429
 protein coding gene Chr7:9673250-9685707 (-)
FVB/NJ ENSMUSG00205032384
 protein coding gene Chr7:6884946-6897402 (-)
JF1/MsJ ENSUMUG00000038083
 protein coding gene Chr7:9321290-9333670 (-)
LP/J ENSMUSG00230043518
 protein coding gene Chr7:13855764-13868230 (-)
NOD/ShiLtJ ENSMUSG00190049057
 protein coding gene Chr7:10763812-10776267 (-)
NZO/HlLtJ ENSMUSG00225053565
 protein coding gene Chr7:11336756-11349227 (-)
PWK/PhJ ENSLUMG00010041936
 protein coding gene Chr7:10487452-10499800 (-)
SPRET/EiJ ENSMSPG00010038859
 protein coding gene Chr7:6650949-6663286 (-)
WSB/EiJ ENSIUOG00005051728
 protein coding gene Chr7:18393465-18405964 (+)



Homology
more
  • Human Ortholog
    MZF1, myeloid zinc finger 1
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MZF1, myeloid zinc finger 1
  • Synonyms
    MZF-1, MZF1B, ZFP98, ZNF42, ZSCAN6
  • Links
    NCBI Gene ID: 7593
    UniProt: P28698

  • Chr Location
    19q13.43; chr19:58561915-58573597 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutants are prone to late-onset (>2 yr) neoplasias characterized by infiltration, enlargement and disruption of the liver by monomorphic cells of myeloid origin; hemopoietic progenitors show increased ability to sustain long-term hemopoiesis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    22
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    744
  • Tissues
    126
  • cDNA Data
    13
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000030380 Ensembl Gene Model | MGI Sequence Detail 12462 C57BL/6J ±  kb
    transcript ENSMUST00000182490 Ensembl | MGI Sequence Detail 2872 Not Applicable  
    polypeptide ENSMUSP00000138271 Ensembl | MGI Sequence Detail 814 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 15
      Genomic 1
      cDNA 14

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGD-MRK-35928, MGI:1858228
    References
    more
    • Summaries
      All 43
      Developmental Gene Expression 5
      Gene Ontology 5
      Phenotypes 7
    • Earliest
      J:38835 Hromas R, et al., A retinoic acid-responsive human zinc finger gene, MZF-1, preferentially expressed in myeloid cells. J Biol Chem. 1991 Aug 5;266(22):14183-7
    • Latest
      J:380639 Qu Z, et al., Myeloid zinc finger 1 knockdown promotes osteoclastogenesis and bone loss in part by regulating RANKL-induced ferroptosis of osteoclasts through Nrf2/GPX4 signaling pathway. J Leukoc Biol. 2024 Apr 29;115(5):946-957
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory