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Pcsk7 Gene Detail
Summary
  • Symbol
    Pcsk7
  • Name
    proprotein convertase subtilisin/kexin type 7
  • Synonyms
    SPC7
  • Feature Type
    protein coding gene
  • IDs
    MGI:107421
    NCBI Gene: 18554
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:45817795-45841024 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 25.32 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    398 from dbSNP Build 142
  • Strain Annotations
    19
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107421
 protein coding gene Chr9:45817745-45843405 (+)
129S1/SvImJ ENSMUSG00200018451
 protein coding gene Chr9:42900605-42923964 (+)
A/J ENSMUSG00195020841
 protein coding gene Chr9:42664809-42688047 (+)
AKR/J ENSMUSG00220032013
 protein coding gene Chr9:42742445-42765666 (+)
BALB/cJ ENSMUSG00180029047
 protein coding gene Chr9:42776455-42799685 (+)
C3H/HeJ ENSMUSG00175012665
 protein coding gene Chr9:42788344-42811572 (+)
C57BL/6NJ ENSMUSG00215023109
 protein coding gene Chr9:42738469-42761700 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032150
 protein coding gene Chr9:42789853-42813052 (+)
CAST/EiJ ENSTCUG00005013284
 protein coding gene Chr9:42731524-42754762 (+)
CBA/J ENSMUSG00210016031
 protein coding gene Chr9:42828176-42851393 (+)
DBA/2J ENSMUSG00185011565
 protein coding gene Chr9:42903052-42926284 (+)
FVB/NJ ENSMUSG00205017961
 protein coding gene Chr9:43142310-43165538 (+)
JF1/MsJ ENSUMUG00000013315
 protein coding gene Chr9:42940845-42964206 (+)
LP/J ENSMUSG00230037413
 protein coding gene Chr9:43190925-43214283 (+)
NOD/ShiLtJ ENSMUSG00190019578
 protein coding gene Chr9:42981717-43004944 (+)
NZO/HlLtJ ENSMUSG00225041625
 protein coding gene Chr9:43152768-43175986 (+)
PWK/PhJ ENSLUMG00010018285
 protein coding gene Chr9:42897700-42921008 (+)
SPRET/EiJ ENSMSPG00010010357
 protein coding gene Chr9:43659492-43682684 (+)
WSB/EiJ ENSIUOG00005017628
 protein coding gene Chr9:42391043-42414267 (+)



Homology
more
  • Human Ortholog
    PCSK7, proprotein convertase subtilisin/kexin type 7
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PCSK7, proprotein convertase subtilisin/kexin type 7
  • Synonyms
    LPC, PC7, PC8, SPC7
  • Links
    NCBI Gene ID: 9159
    UniProt: Q16549

  • Chr Location
    11q23.3; chr11:117204337-117232528 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from multigenic genotypes
    7 phenotype references
Mice homozygous for a knock-out allele exhibit normal response to LPS.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    14
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    605
  • Tissues
    8
  • cDNA Data
    12
  • Literature Summary
    5
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000035382 Ensembl Gene Model | MGI Sequence Detail 23230 C57BL/6J ±  kb
transcript ENSMUST00000216672 Ensembl | MGI Sequence Detail 3599 Not Applicable  
polypeptide ENSMUSP00000150393 Ensembl | MGI Sequence Detail 770 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 15
    cDNA 12
    Primer pair 3

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-35891, MGI:2142967
References
more
  • Summaries
    All 39
    Developmental Gene Expression 5
    Gene Ontology 7
    Phenotypes 7
  • Earliest
    J:34068 Constam DB, et al., SPC4, SPC6, and the novel protease SPC7 are coexpressed with bone morphogenetic proteins at distinct sites during embryogenesis. J Cell Biol. 1996 Jul;134(1):181-91
  • Latest
    J:343652 Sachan V, et al., PCSK7: A novel regulator of apolipoprotein B and a potential target against non-alcoholic fatty liver disease. Metabolism. 2024 Jan;150:155736
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/15/2026
MGI 6.29 		The Jackson Laboratory