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Pcsk7 Gene Detail
Summary
  • Symbol
    Pcsk7
  • Name
    proprotein convertase subtilisin/kexin type 7
  • Synonyms
    SPC7
  • Feature Type
    protein coding gene
  • IDs
    MGI:107421
    NCBI Gene: 18554
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:45817795-45841024 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 25.32 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    116 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107421
 protein coding gene Chr9:45817745-45843405 (+)
129S1/SvImJ MGP_129S1SvImJ_G0034743
 protein coding gene Chr9:44503073-44533978 (+)
A/J MGP_AJ_G0034724
 protein coding gene Chr9:43251618-43274539 (+)
AKR/J MGP_AKRJ_G0034651
 protein coding gene Chr9:44134849-44157864 (+)
BALB/cJ MGP_BALBcJ_G0034715
 protein coding gene Chr9:42975228-42998611 (+)
C3H/HeJ MGP_C3HHeJ_G0034426
 protein coding gene Chr9:44610463-44634691 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035236
 protein coding gene Chr9:45788308-45812438 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032150
 protein coding gene Chr9:42789853-42813052 (+)
CAST/EiJ MGP_CASTEiJ_G0033748
 protein coding gene Chr9:44460922-44484022 (+)
CBA/J MGP_CBAJ_G0034398
 protein coding gene Chr9:47467605-47491653 (+)
DBA/2J MGP_DBA2J_G0034557
 protein coding gene Chr9:43125115-43148747 (+)
FVB/NJ MGP_FVBNJ_G0034498
 protein coding gene Chr9:42392931-42415607 (+)
LP/J MGP_LPJ_G0034638
 protein coding gene Chr9:44827243-44851662 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0034542
 protein coding gene Chr9:49242844-49267582 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035257
 protein coding gene Chr9:44048443-44072510 (+)
PWK/PhJ MGP_PWKPhJ_G0033453
 protein coding gene Chr9:43031890-43055597 (+)
SPRET/EiJ MGP_SPRETEiJ_G0033289
 protein coding gene Chr9:44373199-44395983 (+)
WSB/EiJ MGP_WSBEiJ_G0033861
 protein coding gene Chr9:44096747-44120465 (+)



Homology
more
  • Human Ortholog
    PCSK7, proprotein convertase subtilisin/kexin type 7
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PCSK7, proprotein convertase subtilisin/kexin type 7
  • Synonyms
    LPC, PC7, PC8, SPC7
  • Links
    NCBI Gene ID: 9159
    neXtProt AC: NX_Q16549
    UniProt: Q16549

  • Chr Location
    11q23.3; chr11:117204337-117232525 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    7 phenotype references
Mice homozygous for a knock-out allele exhibit normal response to LPS.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    8
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    712
  • Tissues
    6
  • cDNA Data
    12
  • Literature Summary
    5
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000035382 Ensembl Gene Model | MGI Sequence Detail 23230 C57BL/6J ±  kb
transcript ENSMUST00000216672 Ensembl | MGI Sequence Detail 3599 Not Applicable  
polypeptide ENSMUSP00000150393 Ensembl | MGI Sequence Detail 770 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 14
    cDNA 12
    Primer pair 2

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-35891, MGI:2142967
References
more
  • Summaries
    All 35
    Developmental Gene Expression 5
    Gene Ontology 4
    Phenotypes 7
  • Earliest
    J:34068 Constam DB, et al., SPC4, SPC6, and the novel protease SPC7 are coexpressed with bone morphogenetic proteins at distinct sites during embryogenesis. J Cell Biol. 1996 Jul;134(1):181-91
  • Latest
    J:343652 Sachan V, et al., PCSK7: A novel regulator of apolipoprotein B and a potential target against non-alcoholic fatty liver disease. Metabolism. 2024 Jan;150:155736
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory