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Cct2 Gene Detail
Summary
  • Symbol
    Cct2
  • Name
    chaperonin containing TCP1 subunit 2
  • Synonyms
    Cctb
  • Feature Type
    protein coding gene
  • IDs
    MGI:107186
    NCBI Gene: 12461
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:116886906-116899719 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 65.07 cM, cytoband D2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    490 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107186
 protein coding gene Chr10:116886902-116899757 (-)
129S1/SvImJ ENSMUSG00200024980
 protein coding gene Chr10:113297157-113309964 (-)
A/J ENSMUSG00195019970
 protein coding gene Chr10:113731916-113744729 (-)
AKR/J ENSMUSG00220014588
 protein coding gene Chr10:113305526-113318340 (-)
BALB/cJ ENSMUSG00180016120
 protein coding gene Chr10:113748850-113761664 (-)
C3H/HeJ ENSMUSG00175023858
 protein coding gene Chr10:113694077-113706904 (-)
C57BL/6NJ ENSMUSG00215012345
 protein coding gene Chr10:113390138-113402951 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015827
 protein coding gene Chr10:109837914-109851752 (-)
CAST/EiJ ENSTCUG00005031134
 protein coding gene Chr10:112714438-112727649 (-)
CBA/J ENSMUSG00210020597
 protein coding gene Chr10:113543658-113556485 (-)
DBA/2J ENSMUSG00185007901
 protein coding gene Chr10:113668212-113681025 (-)
FVB/NJ ENSMUSG00205016268
 protein coding gene Chr10:112992800-113005614 (-)
JF1/MsJ ENSUMUG00000012852
 protein coding gene Chr10:114986046-114999074 (-)
LP/J ENSMUSG00230022604
 protein coding gene Chr10:115617963-115630790 (-)
NOD/ShiLtJ ENSMUSG00190017846
 protein coding gene Chr10:113793368-113806181 (-)
NZO/HlLtJ ENSMUSG00225017181
 protein coding gene Chr10:119872026-119884839 (-)
PWK/PhJ ENSLUMG00010012336
 protein coding gene Chr10:113371424-113384476 (-)
SPRET/EiJ ENSMSPG00010014767
 protein coding gene Chr10:115313091-115325766 (-)
WSB/EiJ ENSIUOG00005012851
 protein coding gene Chr10:113387143-113400014 (-)



Homology
more
  • Human Ortholog
    CCT2, chaperonin containing TCP1 subunit 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CCT2, chaperonin containing TCP1 subunit 2
  • Synonyms
    99D8.1, CCTB, CCT-beta, HEL-S-100n, PRO1633, TCP-1-beta
  • Links
    NCBI Gene ID: 10576
    UniProt: P78371

  • Chr Location
    12q15; chr12:69585423-69601577 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Cct2 mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 2 alleles in 2 genetic backgrounds
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    42
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    610
  • Tissues
    11
  • cDNA Data
    643
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000034024 Ensembl Gene Model | MGI Sequence Detail 12814 C57BL/6J ±  kb
    transcript ENSMUST00000047672 Ensembl | MGI Sequence Detail 1959 Not Applicable  
    polypeptide ENSMUSP00000036288 Ensembl | MGI Sequence Detail 535 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 646
      cDNA 643
      Primer pair 1
      Other 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-35647
    References
    more
    • Summaries
      All 62
      Developmental Gene Expression 4
      Diseases 1
      Gene Ontology 13
      Phenotypes 14
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:380488 Liu L, et al., Ubiquitin ligase subunit FBXO9 inhibits V-ATPase assembly and impedes lung cancer metastasis. Exp Hematol Oncol. 2024 Mar 14;13(1):32
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory