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Cct8 Gene Detail
Summary
  • Symbol
    Cct8
  • Name
    chaperonin containing TCP1 subunit 8
  • Synonyms
    Cctq, Tcpq
  • Feature Type
    protein coding gene
  • IDs
    MGI:107183
    NCBI Gene: 12469
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:87280213-87292757 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 49.57 cM, cytoband C3.3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    486 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107183
 protein coding gene Chr16:87280213-87292761 (-)
129S1/SvImJ ENSMUSG00200036662
 protein coding gene Chr16:84144313-84156862 (-)
A/J ENSMUSG00195025823
 protein coding gene Chr16:83946473-83959027 (-)
AKR/J ENSMUSG00220015440
 protein coding gene Chr16:84147485-84160034 (-)
BALB/cJ ENSMUSG00180014426
 protein coding gene Chr16:84028152-84040700 (-)
C3H/HeJ ENSMUSG00175014321
 protein coding gene Chr16:84354127-84366681 (-)
C57BL/6NJ ENSMUSG00215021743
 protein coding gene Chr16:84160428-84172975 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020900
 protein coding gene Chr16:81991086-82003539 (-)
CAST/EiJ ENSTCUG00005019747
 protein coding gene Chr16:83720296-83732877 (-)
CBA/J ENSMUSG00210037162
 protein coding gene Chr16:84254000-84266548 (-)
DBA/2J ENSMUSG00185032338
 protein coding gene Chr16:84207002-84219549 (-)
FVB/NJ ENSMUSG00205015352
 protein coding gene Chr16:83997633-84010187 (-)
JF1/MsJ ENSUMUG00000027280
 protein coding gene Chr16:84300467-84312696 (-)
LP/J ENSMUSG00230032639
 protein coding gene Chr16:86705380-86717929 (-)
NOD/ShiLtJ ENSMUSG00190023424
 protein coding gene Chr16:84163310-84175864 (-)
NZO/HlLtJ ENSMUSG00225030707
 protein coding gene Chr16:89884522-89897070 (-)
PWK/PhJ ENSLUMG00010012078
 protein coding gene Chr16:83958585-83970935 (-)
SPRET/EiJ ENSMSPG00010029191
 protein coding gene Chr16:85075036-85086222 (-)
WSB/EiJ ENSIUOG00005018549
 protein coding gene Chr16:84153822-84166381 (-)



Homology
more
  • Human Ortholog
    CCT8, chaperonin containing TCP1 subunit 8
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CCT8, chaperonin containing TCP1 subunit 8
  • Synonyms
    C21orf112, Cctq, D21S246, PRED71
  • Links
    NCBI Gene ID: 10694
    UniProt: P50990

  • Chr Location
    21q21.3; chr21:29055805-29073797 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    1 images
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele show complete embryonic lethality prior to organogenesis. In vitro, embryos fail to hatch from the zona pellucida and die after 3 days in culture, never forming outgrowths.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    34
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    665
  • Tissues
    66
  • cDNA Data
    407
  • Literature Summary
    4
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 12469 NCBI Gene Model | MGI Sequence Detail 12545 C57BL/6J ±  kb
transcript NM_009840 RefSeq | MGI Sequence Detail 2391 C57BL/6  
polypeptide P42932 UniProt | EBI | MGI Sequence Detail 548 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    12 Sequences
  • Protein Ontology
    PR:000005157 T-complex protein 1 subunit theta
    (term hierarchy)
  • EC
    3.6.1.-
  • InterPro Domains
    IPR002423 Chaperonin Cpn60/GroEL/TCP-1 family
    IPR002194 Chaperonin TCP-1, conserved site
    IPR027409 GroEL-like apical domain superfamily
    IPR027413 GroEL-like equatorial domain superfamily
    IPR017998 T-complex protein 1
    IPR012721 T-complex protein 1, theta subunit
    IPR027410 TCP-1-like chaperonin intermediate domain superfamily
  • GlyGen
    P42932 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 409
    cDNA 407
    Primer pair 1
    Other 1

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-35644, MGI:2146380
References
more
  • Summaries
    All 70
    Developmental Gene Expression 4
    Gene Ontology 13
    Phenotypes 21
  • Earliest
    J:18119 O'Bryan JP, et al., axl, a transforming gene isolated from primary human myeloid leukemia cells, encodes a novel receptor tyrosine kinase. Mol Cell Biol. 1991 Oct;11(10):5016-31
  • Latest
    J:361105 Tateossian H, et al., DYRK1A kinase triplication is the major cause of Otitis Media in Down Syndrome. Elife. 2025;
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/01/2026
MGI 6.24 		The Jackson Laboratory