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Hmx3 Gene Detail
Summary
  • Symbol
    Hmx3
  • Name
    H6 homeobox 3
  • Synonyms
    Nkx5-1, Nkx5.1
  • Feature Type
    protein coding gene
  • IDs
    MGI:107160
    NCBI Gene: 15373
  • Alliance
    gene page
Location &
Maps
more
  • Sequence Map
    Chr7:131144596-131146654 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 74.32 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    9 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107160
 protein coding gene Chr7:131143263-131147756 (+)
129S1/SvImJ MGP_129S1SvImJ_G0033106
 protein coding gene Chr7:136178922-136180980 (+)
A/J MGP_AJ_G0033088
 protein coding gene Chr7:132456386-132458444 (+)
AKR/J MGP_AKRJ_G0033020
 protein coding gene Chr7:135964478-135966536 (+)
BALB/cJ MGP_BALBcJ_G0033089
 protein coding gene Chr7:132136162-132138220 (+)
C3H/HeJ MGP_C3HHeJ_G0032803
 protein coding gene Chr7:135815161-135817219 (+)
C57BL/6NJ MGP_C57BL6NJ_G0033600
 protein coding gene Chr7:141381023-141383081 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030571
 protein coding gene Chr7:133720379-133722438 (+)
CAST/EiJ MGP_CASTEiJ_G0032133
 protein coding gene Chr7:127668919-127670980 (+)
CBA/J MGP_CBAJ_G0032776
 protein coding gene Chr7:146240417-146242475 (+)
DBA/2J MGP_DBA2J_G0032928
 protein coding gene Chr7:130434443-130436501 (+)
FVB/NJ MGP_FVBNJ_G0032881
 protein coding gene Chr7:130296295-130298353 (+)
LP/J MGP_LPJ_G0033022
 protein coding gene Chr7:137669079-137671137 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0032913
 protein coding gene Chr7:147177762-147179820 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0033620
 protein coding gene Chr7:134959257-134961315 (+)
PWK/PhJ MGP_PWKPhJ_G0031839
 protein coding gene Chr7:123465846-123467914 (+)
SPRET/EiJ MGP_SPRETEiJ_G0031685
 protein coding gene Chr7:121743813-121745874 (+)
WSB/EiJ MGP_WSBEiJ_G0032244
 protein coding gene Chr7:135861589-135863647 (+)



Homology
more
  • Human Ortholog
    HMX3, H6 family homeobox 3
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HMX3, H6 family homeobox 3
  • Synonyms
    Nkx5-1, NKX-5.1, NKX5.1
  • Links
    NCBI Gene ID: 340784
    neXtProt AC: NX_A6NHT5
    UniProt: A6NHT5

  • Chr Location
    10q26.13; chr10:123135970-123139423 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    37 phenotypes from 4 alleles in 4 genetic backgrounds
    11 phenotypes from multigenic genotypes
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit hyperactivity and circling behavior, and severe vestibular defects. Mutant females are infertile due to failure of implantation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    15
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1004
  • Tissues
    213
  • cDNA Data
    9
  • Literature Summary
    58
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000040148 Ensembl Gene Model | MGI Sequence Detail 2059 C57BL/6J ±  kb
    transcript ENSMUST00000046093 Ensembl | MGI Sequence Detail 1457 Not Applicable  
    polypeptide ENSMUSP00000039018 Ensembl | MGI Sequence Detail 356 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 28
      Genomic 8
      cDNA 11
      Primer pair 2
      Other 7

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-12895, MGD-MRK-35621
    References
    more
    • Summaries
      All 86
      Developmental Gene Expression 58
      Gene Ontology 6
      Phenotypes 7
    • Earliest
      J:17126 Bober E, et al., A novel NK-related mouse homeobox gene: expression in central and peripheral nervous structures during embryonic development. Dev Biol. 1994 Mar;162(1):288-303
    • Latest
      J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/09/2024
    MGI 6.23     		The Jackson Laboratory