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Gpx2 Gene Detail
Summary
  • Symbol
    Gpx2
  • Name
    glutathione peroxidase 2
  • Synonyms
    GI-GPx, GPx-GI, intestinal GPx
  • Feature Type
    protein coding gene
  • IDs
    MGI:106609
    NCBI Gene: 14776
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:76839107-76842273 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 33.73 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    23 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_106609
 protein coding gene Chr12:76839107-76842328 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019865
 protein coding gene Chr12:76918789-76922000 (-)
A/J MGP_AJ_G0019823
 protein coding gene Chr12:73988618-73991839 (-)
AKR/J MGP_AKRJ_G0019798
 protein coding gene Chr12:76230368-76233587 (-)
BALB/cJ MGP_BALBcJ_G0019802
 protein coding gene Chr12:74460941-74464158 (-)
C3H/HeJ MGP_C3HHeJ_G0019608
 protein coding gene Chr12:76695932-76699153 (-)
C57BL/6NJ MGP_C57BL6NJ_G0020254
 protein coding gene Chr12:79272407-79275749 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017872
 protein coding gene Chr12:71331518-71334693 (-)
CAST/EiJ MGP_CASTEiJ_G0019159
 protein coding gene Chr12:71507856-71511060 (-)
CBA/J MGP_CBAJ_G0019578
 protein coding gene Chr12:82340640-82343861 (-)
DBA/2J MGP_DBA2J_G0019694
 protein coding gene Chr12:73861953-73865170 (-)
FVB/NJ MGP_FVBNJ_G0019681
 protein coding gene Chr12:72684361-72687790 (-)
LP/J MGP_LPJ_G0019766
 protein coding gene Chr12:76892737-76895948 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019720
 protein coding gene Chr12:85346490-85349709 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0020290
 protein coding gene Chr12:75718638-75721859 (-)
PWK/PhJ MGP_PWKPhJ_G0018925
 protein coding gene Chr12:68201885-68205162 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018719
 protein coding gene Chr12:70218114-70221343 (-)
WSB/EiJ MGP_WSBEiJ_G0019211
 protein coding gene Chr12:76325918-76329133 (-)



Homology
more
  • Human Ortholog
    GPX2, glutathione peroxidase 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GPX2, glutathione peroxidase 2
  • Synonyms
    GI-GPx, GPRP, GPRP-2, GPx-2, GPx-GI, GSHPx-2, GSHPX-GI
  • Links
    NCBI Gene ID: 2877
    neXtProt AC: NX_P18283
    UniProt: P18283

  • Chr Location
    14q23.3; chr14:64939152-64942746 (-)  GRCh38
Human Diseases
less
  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 2 alleles in 1 genetic background
    15 phenotypes from multigenic genotypes
    24 phenotype references
Homozygotes for a targeted null allele appear normal, but double knockouts of Gpx1 and Gpx2 exhibit symptoms of inflammatory bowel disease, including perianal ulceration, growth retardation, and hypothermia, a condition that is sometimes fatal not observed in either single knockout.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    23
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1115
  • Tissues
    288
  • cDNA Data
    11
  • Literature Summary
    11
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000042808 Ensembl Gene Model | MGI Sequence Detail 3167 C57BL/6J ±  kb
transcript ENSMUST00000082431 Ensembl | MGI Sequence Detail 1010 Not Applicable  
polypeptide ENSMUSP00000081012 Ensembl | MGI Sequence Detail 190 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 18
    Genomic 2
    cDNA 13
    Primer pair 3

    Microarray probesets 2
Other
Accession IDs
less
MGD-MRK-35066
References
more
  • Summaries
    All 64
    Developmental Gene Expression 11
    Diseases 1
    Gene Ontology 10
    Phenotypes 24
  • Earliest
    J:32889 Chu FF, et al., The mouse glutathione peroxidase Gpx2 gene maps to chromosome 12; its pseudogene Gpx2-ps maps to chromosome 7. Genomics. 1996 May 1;33(3):516-8
  • Latest
    J:259708 Lennicke C, et al., Loss of epithelium-specific GPx2 results in aberrant cell fate decisions during intestinal differentiation. Oncotarget. 2018 Jan 2;9(1):539-552
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory