About   Help   FAQ
Chpf Gene Detail
Summary
  • Symbol
    Chpf
  • Name
    chondroitin polymerizing factor
  • Synonyms
    1700028N03Rik, D1Bwg1363e
  • Feature Type
    protein coding gene
  • IDs
    MGI:106576
    NCBI Gene: 74241
  • Alliance
    genome feature page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:75451213-75455951 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 39.14 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    109 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_106576
 protein coding gene Chr1:75451213-75456115 (-)
129S1/SvImJ ENSMUSG00200034976
 protein coding gene Chr1:73111966-73116666 (-)
A/J ENSMUSG00195009675
 protein coding gene Chr1:72536220-72540921 (-)
AKR/J ENSMUSG00220009833
 protein coding gene Chr1:72687437-72692138 (-)
BALB/cJ ENSMUSG00180019117
 protein coding gene Chr1:72798103-72802807 (-)
C3H/HeJ ENSMUSG00175017571
 protein coding gene Chr1:72936574-72941276 (-)
C57BL/6NJ ENSMUSG00215009532
 protein coding gene Chr1:72843435-72848138 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014301
 protein coding gene Chr1:68957771-68962281 (-)
CAST/EiJ ENSTCUG00005024977
 protein coding gene Chr1:72561069-72565776 (-)
CBA/J ENSMUSG00210040519
 protein coding gene Chr1:72620168-72624871 (-)
DBA/2J ENSMUSG00185029544
 protein coding gene Chr1:73715412-73720113 (-)
FVB/NJ ENSMUSG00205024636
 protein coding gene Chr1:72298936-72303636 (-)
JF1/MsJ ENSUMUG00000003105
 protein coding gene Chr1:72613354-72618065 (-)
LP/J ENSMUSG00230011388
 protein coding gene Chr1:73705030-73709730 (-)
NOD/ShiLtJ ENSMUSG00190030380
 protein coding gene Chr1:72852364-72857063 (-)
NZO/HlLtJ ENSMUSG00225039681
 protein coding gene Chr1:76920176-76924876 (-)
PWK/PhJ ENSLUMG00010011601
 protein coding gene Chr1:72193853-72198562 (-)
SPRET/EiJ ENSMSPG00010017081
 protein coding gene Chr1:74278566-74283065 (-)
WSB/EiJ ENSIUOG00005012508
 protein coding gene Chr1:72467465-72472164 (-)



Homology
more
  • Human Ortholog
    CHPF, chondroitin polymerizing factor
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CHPF, chondroitin polymerizing factor
  • Synonyms
    CHPF1, CHSY2, CSS2
  • Links
    NCBI Gene ID: 79586
    UniProt: Q8IZ52

  • Chr Location
    2q35; chr2:219538949-219543818 (-)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 4 alleles in 3 genetic backgrounds
    30 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mice are viable and no detectable mutant phenotype is reported. Mice homozygous for another knock-out allele exhibit slight reduction in femur and tibia length.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    33
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    705
  • Tissues
    99
  • cDNA Data
    58
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000032997 Ensembl Gene Model | MGI Sequence Detail 4739 C57BL/6J ±  kb
    transcript ENSMUST00000079205 Ensembl | MGI Sequence Detail 2892 Not Applicable  
    polypeptide ENSMUSP00000078199 Ensembl | MGI Sequence Detail 774 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000005448 chondroitin sulfate synthase 2
      (term hierarchy)
    • InterPro Domains
      IPR008428 Chondroitin N-acetylgalactosaminyltransferase
      IPR051227 Chondroitin sulfate glycosyltransferase
    • GlyGen
      Q6IQX7 3 sites, 2 N-linked glycans (3 sites)
    Molecular
    Reagents
    less
    • All nucleic 65
      Genomic 2
      cDNA 58
      Primer pair 3
      Other 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-34270, MGI:1921491, MGI:2138222
    References
    more
    • Summaries
      All 73
      Developmental Gene Expression 6
      Diseases 1
      Gene Ontology 12
      Phenotypes 30
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory