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Eif3b Gene Detail
Summary
  • Symbol
    Eif3b
  • Name
    eukaryotic translation initiation factor 3, subunit B
  • Synonyms
    D5Wsu45e, EIF3-P116, Eif3s9
  • Feature Type
    protein coding gene
  • IDs
    MGI:106478
    NCBI Gene: 27979
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:140405083-140429115 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 78.97 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    42 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_106478
 protein coding gene Chr5:140405060-140429115 (+)
129S1/SvImJ MGP_129S1SvImJ_G0030299
 protein coding gene Chr5:145485666-145513921 (+)
A/J MGP_AJ_G0030268
 protein coding gene Chr5:139298904-139325582 (+)
AKR/J MGP_AKRJ_G0030200
 protein coding gene Chr5:143653783-143676948 (+)
BALB/cJ MGP_BALBcJ_G0030285
 protein coding gene Chr5:140539137-140562565 (+)
C3H/HeJ MGP_C3HHeJ_G0029996
 protein coding gene Chr5:144428712-144453130 (+)
C57BL/6NJ MGP_C57BL6NJ_G0030730
 protein coding gene Chr5:150876837-150901802 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027948
 protein coding gene Chr5:133143871-133167426 (+)
CAST/EiJ MGP_CASTEiJ_G0029401
 protein coding gene Chr5:143855897-143878900 (+)
CBA/J MGP_CBAJ_G0029966
 protein coding gene Chr5:157071705-157101077 (+)
DBA/2J MGP_DBA2J_G0030116
 protein coding gene Chr5:139108354-139134110 (+)
FVB/NJ MGP_FVBNJ_G0030071
 protein coding gene Chr5:138255879-138282519 (+)
LP/J MGP_LPJ_G0030202
 protein coding gene Chr5:146097489-146127277 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0030102
 protein coding gene Chr5:159663603-159688887 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030770
 protein coding gene Chr5:143486463-143512467 (+)
PWK/PhJ MGP_PWKPhJ_G0029116
 protein coding gene Chr5:138130615-138154276 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028952
 protein coding gene Chr5:141189245-141212103 (+)
WSB/EiJ MGP_WSBEiJ_G0029475
 protein coding gene Chr5:144266979-144290310 (+)



Homology
more
  • Human Ortholog
    EIF3B, eukaryotic translation initiation factor 3 subunit B
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    EIF3B, eukaryotic translation initiation factor 3 subunit B
  • Synonyms
    EIF3-ETA, EIF3-P110, EIF3-P116, EIF3S9, PRT1
  • Links
    NCBI Gene ID: 8662
    neXtProt AC: NX_P55884
    UniProt: P55884

  • Chr Location
    7p22.3; chr7:2354086-2380745 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous embryos die prenatally prior to the blastocyst stage.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    28
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    738
  • Tissues
    25
  • cDNA Data
    277
  • Literature Summary
    4
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000056076 Ensembl Gene Model | MGI Sequence Detail 24033 C57BL/6J ±  kb
transcript ENSMUST00000100507 Ensembl | MGI Sequence Detail 2945 Not Applicable  
polypeptide ENSMUSP00000098076 Ensembl | MGI Sequence Detail 803 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000006974 eukaryotic translation initiation factor 3 subunit B
    (term hierarchy)
  • InterPro Domains
    IPR034363 eIF3B, RNA recognition motif
    IPR011400 Eukaryotic translation initiation factor 3 subunit B
    IPR012677 Nucleotide-binding alpha-beta plait domain superfamily
    IPR035979 RNA-binding domain superfamily
    IPR000504 RNA recognition motif domain
    IPR013979 Translation initiation factor, beta propellor-like domain
    IPR015943 WD40/YVTN repeat-like-containing domain superfamily
Molecular
Reagents
less
  • All nucleic 279
    cDNA 277
    Primer pair 2

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-34172, MGI:2141022, MGI:2141024, MGI:2141170
References
more
  • Summaries
    All 45
    Developmental Gene Expression 4
    Gene Ontology 11
    Phenotypes 7
  • Earliest
    J:44426 Neidhardt LM, et al., A mouse gene of the paired-related homeobox class expressed in the caudal somite compartment and in the developing vertebral column, kidney and nervous system. Dev Genes Evol. 1997 OCT;207(5):330-339
  • Latest
    J:346062 Perez RC, et al., TOB1 and TOB2 mark distinct RNA processing granules in differentiating lens fiber cells. J Mol Histol. 2024 Feb;55(1):121-138
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory