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Rtcb Gene Detail
Summary
  • Symbol
    Rtcb
  • Name
    RNA 2',3'-cyclic phosphate and 5'-OH ligase
  • Synonyms
    D10Wsu52e, HSPC117
  • Feature Type
    protein coding gene
  • IDs
    MGI:106379
    NCBI Gene: 28088
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:85774501-85793657 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 41.81 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    90 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_106379
 protein coding gene Chr10:85774501-85793687 (-)
129S1/SvImJ MGP_129S1SvImJ_G0017605
 protein coding gene Chr10:86878886-86900655 (-)
A/J MGP_AJ_G0017585
 protein coding gene Chr10:83987452-84007973 (-)
AKR/J MGP_AKRJ_G0017545
 protein coding gene Chr10:86335816-86361876 (-)
BALB/cJ MGP_BALBcJ_G0017548
 protein coding gene Chr10:84215511-84235243 (-)
C3H/HeJ MGP_C3HHeJ_G0017371
 protein coding gene Chr10:86368233-86387124 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018005
 protein coding gene Chr10:89836527-89860259 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015689
 protein coding gene Chr10:79814321-79835570 (-)
CAST/EiJ MGP_CASTEiJ_G0016937
 protein coding gene Chr10:86225514-86245108 (-)
CBA/J MGP_CBAJ_G0017340
 protein coding gene Chr10:93546638-93568661 (-)
DBA/2J MGP_DBA2J_G0017447
 protein coding gene Chr10:83100426-83120523 (-)
FVB/NJ MGP_FVBNJ_G0017440
 protein coding gene Chr10:82368311-82387145 (-)
LP/J MGP_LPJ_G0017519
 protein coding gene Chr10:87559512-87578405 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0017468
 protein coding gene Chr10:95185863-95207620 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018042
 protein coding gene Chr10:86212131-86231570 (-)
PWK/PhJ MGP_PWKPhJ_G0016718
 protein coding gene Chr10:83104898-83123692 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016507
 protein coding gene Chr10:84857583-84876223 (-)
WSB/EiJ MGP_WSBEiJ_G0016995
 protein coding gene Chr10:86172235-86191053 (-)



Homology
more
  • Human Ortholog
    RTCB, RNA 2',3'-cyclic phosphate and 5'-OH ligase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RTCB, RNA 2',3'-cyclic phosphate and 5'-OH ligase
  • Synonyms
    C22orf28, DJ149A16.6, FAAP, HSPC117
  • Links
    NCBI Gene ID: 51493
    neXtProt AC: NX_Q9Y3I0
    UniProt: Q9Y3I0

  • Chr Location
    22q12.3; chr22:32387582-32412248 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 2 alleles in 2 genetic backgrounds
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice lacking expression in B cells show impaired immunoglobin secretion.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    27
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    759
  • Tissues
    22
  • cDNA Data
    241
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 28088 NCBI Gene Model | MGI Sequence Detail 19157 C57BL/6J ±  kb
    transcript NM_145422 RefSeq | MGI Sequence Detail 1979 ZRU/MplStud  
    polypeptide Q99LF4 UniProt | EBI | MGI Sequence Detail 505 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 244
      cDNA 241
      Primer pair 3

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-34072, MGI:2143544, MGI:2143620
    References
    more
    • Summaries
      All 39
      Developmental Gene Expression 4
      Gene Ontology 7
      Phenotypes 9
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:330334 Zhang H, et al., The RNA ligase RNA terminal phosphate cyclase B regulates mRNA alternative splicing and is required for mouse oocyte development and maintenance. Development. 2022 Oct 1;149(19):dev200497
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory