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Vps25 Gene Detail
Summary
  • Symbol
    Vps25
  • Name
    vacuolar protein sorting 25
  • Synonyms
    1110020N13Rik, D11Wsu68e
  • Feature Type
    protein coding gene
  • IDs
    MGI:106354
    NCBI Gene: 28084
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:101144533-101150375 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 64.48 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    15 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_106354
 protein coding gene Chr11:101144533-101150377 (+)
129S1/SvImJ MGP_129S1SvImJ_G0019189
 protein coding gene Chr11:104094534-104102694 (+)
A/J MGP_AJ_G0019157
 protein coding gene Chr11:99719867-99726629 (+)
AKR/J MGP_AKRJ_G0019126
 protein coding gene Chr11:102817968-102823736 (+)
BALB/cJ MGP_BALBcJ_G0019131
 protein coding gene Chr11:100207215-100213014 (+)
C3H/HeJ MGP_C3HHeJ_G0018940
 protein coding gene Chr11:102991474-102997779 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019580
 protein coding gene Chr11:107325320-107338135 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017206
 protein coding gene Chr11:97134418-97140095 (+)
CAST/EiJ MGP_CASTEiJ_G0018494
 protein coding gene Chr11:103980402-103986614 (+)
CBA/J MGP_CBAJ_G0018909
 protein coding gene Chr11:111773133-111780626 (+)
DBA/2J MGP_DBA2J_G0019021
 protein coding gene Chr11:99247088-99253562 (+)
FVB/NJ MGP_FVBNJ_G0019011
 protein coding gene Chr11:98794297-98800310 (+)
LP/J MGP_LPJ_G0019090
 protein coding gene Chr11:104640570-104647652 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019042
 protein coding gene Chr11:111339358-111346308 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019618
 protein coding gene Chr11:103144432-103153347 (+)
PWK/PhJ MGP_PWKPhJ_G0018257
 protein coding gene Chr11:100304056-100309729 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018049
 protein coding gene Chr11:102884556-102890593 (+)
WSB/EiJ MGP_WSBEiJ_G0018543
 protein coding gene Chr11:103140559-103146383 (+)



Homology
more
  • Human Ortholog
    VPS25, vacuolar protein sorting 25 homolog
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    VPS25, vacuolar protein sorting 25 homolog
  • Synonyms
    DERP9, EAP20, FAP20
  • Links
    NCBI Gene ID: 84313
    neXtProt AC: NX_Q9BRG1
    UniProt: Q9BRG1

  • Chr Location
    17q21.2; chr17:42773449-42779599 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    22 phenotypes from 3 alleles in 4 genetic backgrounds
    4 phenotypes from multigenic genotypes
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit embryonic lethality before E8.5. Mice homozygous for a hypomorphic allele exhibit short limbs, polydactyly and craniofacial defects.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    14
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    801
  • Tissues
    45
  • cDNA Data
    161
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000078656 Ensembl Gene Model | MGI Sequence Detail 5843 C57BL/6J ±  kb
    transcript ENSMUST00000107280 Ensembl | MGI Sequence Detail 876 Not Applicable  
    polypeptide ENSMUSP00000102901 Ensembl | MGI Sequence Detail 184 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • Protein Ontology
      PR:000017326 vacuolar protein-sorting-associated protein 25
      (term hierarchy)
    • InterPro Domains
      IPR008570 ESCRT-II complex, Vps25 subunit
      IPR014041 ESCRT-II complex, Vps25 subunit, N-terminal winged helix
      IPR036390 Winged helix DNA-binding domain superfamily
      IPR036388 Winged helix-like DNA-binding domain superfamily
    Molecular
    Reagents
    less
    • All nucleic 164
      cDNA 161
      Primer pair 3

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-34046, MGI:1915833, MGI:2144496
    References
    more
    • Summaries
      All 40
      Developmental Gene Expression 3
      Gene Ontology 4
      Phenotypes 12
    • Earliest
      J:50869 Ko MSH, et al., Genome-wide mapping of unselected transcripts from extraembryonic tissue of 7.5-day mouse embryos reveals enrichment in the t-complex and under-representation on the X chromosome. Hum Mol Genet. 1998 Nov;7(12):1967-78
    • Latest
      J:339600 Hermosilla Aguayo V, et al., ESCRT-dependent control of craniofacial morphogenesis with concomitant perturbation of NOTCH signaling. Dev Biol. 2023 Aug 10;503:25-42
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory