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Dock9 Gene Detail
Summary
  • Symbol
    Dock9
  • Name
    dedicator of cytokinesis 9
  • Synonyms
    B230309H04Rik, D14Wsu89e, mKIAA1058, Zizimin1
  • Feature Type
    protein coding gene
  • IDs
    MGI:106321
    NCBI Gene: 105445
  • Alliance
    gene page
  • Transcription Start Sites
    18 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:121779458-122035249 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 65.28 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2043 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_106321
 protein coding gene Chr14:121772026-122038465 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021663
 protein coding gene Chr14:119365288-119654980 (-)
A/J MGP_AJ_G0021623
 protein coding gene Chr14:114750673-115012558 (-)
AKR/J MGP_AKRJ_G0021599
 protein coding gene Chr14:118464085-118735079 (-)
BALB/cJ MGP_BALBcJ_G0021629
 protein coding gene Chr14:115293863-115559857 (-)
C3H/HeJ MGP_C3HHeJ_G0021407
 protein coding gene Chr14:118357359-118626544 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022069
 protein coding gene Chr14:123963018-124249276 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019607
 protein coding gene Chr14:110643275-110897446 (-)
CAST/EiJ MGP_CASTEiJ_G0020922
 protein coding gene Chr14:116255852-116538328 (-)
CBA/J MGP_CBAJ_G0021375
 protein coding gene Chr14:128687316-128985342 (-)
DBA/2J MGP_DBA2J_G0021498
 protein coding gene Chr14:114621864-114881002 (-)
FVB/NJ MGP_FVBNJ_G0021476
 protein coding gene Chr14:112956014-113231902 (-)
LP/J MGP_LPJ_G0021566
 protein coding gene Chr14:120302132-120576458 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021503
 protein coding gene Chr14:133698447-133982435 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022092
 protein coding gene Chr14:118026320-118306707 (-)
PWK/PhJ MGP_PWKPhJ_G0020666
 protein coding gene Chr14:111672078-111933492 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020504
 protein coding gene Chr14:114218124-114502394 (-)
WSB/EiJ MGP_WSBEiJ_G0020978
 protein coding gene Chr14:118736723-119005450 (-)



Homology
more
  • Human Ortholog
    DOCK9, dedicator of cytokinesis 9
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DOCK9, dedicator of cytokinesis 9
  • Synonyms
    ZIZ1, ZIZIMIN1
  • Links
    NCBI Gene ID: 23348
    neXtProt AC: NX_Q9BZ29
    UniProt: Q9BZ29

  • Chr Location
    13q32.3; chr13:98793429-99088619 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    12 phenotypes from 2 alleles in 2 genetic backgrounds
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele are healthy and viable with no apparent phenotype.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    8
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    724
  • Tissues
    5
  • cDNA Data
    184
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000025558 Ensembl Gene Model | MGI Sequence Detail 255792 C57BL/6J ±  kb
    transcript ENSMUST00000040700 Ensembl | MGI Sequence Detail 7803 Not Applicable  
    polypeptide ENSMUSP00000047881 Ensembl | MGI Sequence Detail 2113 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 188
      cDNA 184
      Primer pair 4

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-34013, MGI:2145584, MGI:2145822, MGI:2444581
    References
    more
    • Summaries
      All 39
      Developmental Gene Expression 3
      Gene Ontology 6
      Phenotypes 8
    • Earliest
      J:50869 Ko MSH, et al., Genome-wide mapping of unselected transcripts from extraembryonic tissue of 7.5-day mouse embryos reveals enrichment in the t-complex and under-representation on the X chromosome. Hum Mol Genet. 1998 Nov;7(12):1967-78
    • Latest
      J:300632 Namekata K, et al., Roles of the DOCK-D family proteins in a mouse model of neuroinflammation. J Biol Chem. 2020 May 8;295(19):6710-6720
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory