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Aqp5 Gene Detail
Summary
  • Symbol
    Aqp5
  • Name
    aquaporin 5
  • Feature Type
    protein coding gene
  • IDs
    MGI:106215
    NCBI Gene: 11830
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:99488909-99492710 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 56.13 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    155 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_106215
 protein coding gene Chr15:99488663-99492710 (+)
129S1/SvImJ ENSMUSG00200050364
 protein coding gene Chr15:96691651-96695698 (+)
A/J ENSMUSG00195037596
 protein coding gene Chr15:96558386-96562433 (+)
AKR/J ENSMUSG00220047052
 protein coding gene Chr15:96565228-96569275 (+)
BALB/cJ ENSMUSG00180044352
 protein coding gene Chr15:96466818-96470864 (+)
C3H/HeJ ENSMUSG00175039072
 protein coding gene Chr15:96738397-96742445 (+)
C57BL/6NJ ENSMUSG00215047494
 protein coding gene Chr15:96527097-96531145 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020270
 protein coding gene Chr15:93300062-93303897 (+)
CAST/EiJ ENSTCUG00005043759
 protein coding gene Chr15:96008701-96012768 (+)
CBA/J ENSMUSG00210030113
 protein coding gene Chr15:96523761-96527807 (+)
DBA/2J ENSMUSG00185038891
 protein coding gene Chr15:96571636-96575683 (+)
FVB/NJ ENSMUSG00205044600
 protein coding gene Chr15:96276327-96280372 (+)
JF1/MsJ ENSUMUG00000044875
 protein coding gene Chr15:96026713-96030741 (+)
LP/J ENSMUSG00230037562
 protein coding gene Chr15:99915021-99919068 (+)
NOD/ShiLtJ ENSMUSG00190039878
 protein coding gene Chr15:96541864-96545911 (+)
NZO/HlLtJ ENSMUSG00225042095
 protein coding gene Chr15:100163982-100168029 (+)
PWK/PhJ ENSLUMG00010042557
 protein coding gene Chr15:96246940-96250985 (+)
SPRET/EiJ ENSMSPG00010046756
 protein coding gene Chr15:98051008-98055054 (+)
WSB/EiJ ENSIUOG00005035761
 protein coding gene Chr15:96652489-96656535 (+)



Homology
more
  • Human Ortholog
    AQP5, aquaporin 5
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    AQP5, aquaporin 5
  • Synonyms
    AQP-5, PPKB
  • Links
    NCBI Gene ID: 362
    UniProt: P55064

  • Chr Location
    12q13.12; chr12:49961811-49965682 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Aqp5 mouse models; 1 with human AQP5 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    20 phenotypes from 3 alleles in 4 genetic backgrounds
    4 phenotypes from multigenic genotypes
    91 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mutants exhibit reduced growth on solid food and secrete diminished amounts of hypertonic, viscous saliva.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    55
  • GO References
    21
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    963
  • Tissues
    139
  • cDNA Data
    98
  • Literature Summary
    161
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 11830 NCBI Gene Model | MGI Sequence Detail 3802 C57BL/6J ±  kb
    transcript NM_009701 RefSeq | MGI Sequence Detail 1551 ZRU/MplStud  
    polypeptide Q9WTY4 UniProt | EBI | MGI Sequence Detail 265 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 128
      Genomic 2
      cDNA 99
      Primer pair 24
      Other 3
      Antibodies 18

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-33907
    References
    more
    • Summaries
      All 313
      Developmental Gene Expression 161
      Diseases 2
      Gene Ontology 21
      Phenotypes 91
    • Earliest
      J:34248 Steinman RM, et al., Dendritic cells are the principal stimulators of the primary mixed leukocyte reaction in mice. J Exp Med. 1983 Feb 1;157(2):613-27
    • Latest
      J:387680 Ahn B, et al., Disorganization of Transcriptional Regulation and Alteration of Keratin Family Gene Expression in Hairy Ear Mice. Genes (Basel). 2026 Jan 31;17(2)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory