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Shc2 Gene Detail
Summary
  • Symbol
    Shc2
  • Name
    SHC (Src homology 2 domain containing) transforming protein 2
  • Synonyms
    ShcB, Sli
  • Feature Type
    protein coding gene
  • IDs
    MGI:106180
    NCBI Gene: 216148
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:79453885-79473752 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 39.72 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    420 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_106180
 protein coding gene Chr10:79453768-79473752 (-)
129S1/SvImJ ENSMUSG00200041109
 protein coding gene Chr10:76076104-76098781 (-)
A/J ENSMUSG00195041187
 protein coding gene Chr10:76471603-76494281 (-)
AKR/J ENSMUSG00220046140
 protein coding gene Chr10:76069179-76091855 (-)
BALB/cJ ENSMUSG00180050752
 protein coding gene Chr10:76482106-76504782 (-)
C3H/HeJ ENSMUSG00175051645
 protein coding gene Chr10:76352803-76375480 (-)
C57BL/6NJ ENSMUSG00215052574
 protein coding gene Chr10:76094483-76117158 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015530
 protein coding gene Chr10:73595699-73615216 (-)
CAST/EiJ ENSTCUG00005048241
 protein coding gene Chr10:75978672-76001453 (-)
CBA/J ENSMUSG00210048480
 protein coding gene Chr10:76208893-76231567 (-)
DBA/2J ENSMUSG00185051077
 protein coding gene Chr10:76551266-76573942 (-)
FVB/NJ ENSMUSG00205049323
 protein coding gene Chr10:76264050-76286729 (-)
JF1/MsJ ENSUMUG00000050800
 protein coding gene Chr10:77781834-77804616 (-)
LP/J ENSMUSG00230047171
 protein coding gene Chr10:78321041-78343716 (-)
NOD/ShiLtJ ENSMUSG00190044384
 protein coding gene Chr10:76465104-76487779 (-)
NZO/HlLtJ ENSMUSG00225050098
 protein coding gene Chr10:82607503-82630179 (-)
PWK/PhJ ENSLUMG00010050402
 protein coding gene Chr10:76141153-76163923 (-)
SPRET/EiJ ENSMSPG00010044617
 protein coding gene Chr10:77765631-77782553 (-)
WSB/EiJ ENSIUOG00005047960
 protein coding gene Chr10:76168586-76191293 (-)



Homology
more
  • Human Ortholog
    SHC2, SHC adaptor protein 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SHC2, SHC adaptor protein 2
  • Synonyms
    SCK, SHCB, SLI
  • Links
    NCBI Gene ID: 25759
    UniProt: P98077

  • Chr Location
    19p13.3; chr19:416589-461100 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    5 phenotypes from multigenic genotypes
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene display sensory nerve defects related to nociception.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    4
  • GO References
    2
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    843
  • Tissues
    62
  • cDNA Data
    31
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000020312 Ensembl Gene Model | MGI Sequence Detail 19868 C57BL/6J ±  kb
    transcript ENSMUST00000020564 Ensembl | MGI Sequence Detail 3243 Not Applicable  
    polypeptide ENSMUSP00000020564 Ensembl | MGI Sequence Detail 573 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 36
      Genomic 1
      cDNA 33
      Primer pair 1
      Other 1
      Antibodies 4

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-33870
    References
    more
    • Summaries
      All 40
      Developmental Gene Expression 4
      Gene Ontology 2
      Phenotypes 11
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:351573 Sasner M, et al., In vivo validation of late-onset Alzheimer's disease genetic risk factors. Alzheimers Dement. 2024 Jul;20(7):4970-4984
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory