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Etfdh Gene Detail
Summary
  • Symbol
    Etfdh
  • Name
    electron transferring flavoprotein, dehydrogenase
  • Synonyms
    0610010I20Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:106100
    NCBI Gene: 66841
  • Alliance
    genome feature page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:79511095-79536074 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 34.91 cM
  • Mapping Data
    7 experiments
Strain
Comparison
more
  • SNPs within 2kb
    820 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_106100
 protein coding gene Chr3:79511095-79536807 (-)
129S1/SvImJ ENSMUSG00200018848
 protein coding gene Chr3:76292006-76316689 (-)
A/J ENSMUSG00195011397
 protein coding gene Chr3:76354940-76380002 (-)
AKR/J ENSMUSG00220001454
 protein coding gene Chr3:76368096-76393162 (-)
BALB/cJ ENSMUSG00180001822
 protein coding gene Chr3:76446860-76471927 (-)
C3H/HeJ ENSMUSG00175007275
 protein coding gene Chr3:76293103-76318161 (-)
C57BL/6NJ ENSMUSG00215001993
 protein coding gene Chr3:76743774-76768851 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025086
 protein coding gene Chr3:72358978-72381423 (-)
CAST/EiJ ENSTCUG00005001684
 protein coding gene Chr3:75854791-75886891 (-)
CBA/J ENSMUSG00210025540
 protein coding gene Chr3:76375513-76400575 (-)
DBA/2J ENSMUSG00185012496
 protein coding gene Chr3:76531598-76556660 (-)
FVB/NJ ENSMUSG00205006321
 protein coding gene Chr3:75388264-75413334 (-)
JF1/MsJ ENSUMUG00000000851
 protein coding gene Chr3:76118461-76142913 (-)
LP/J ENSMUSG00230008895
 protein coding gene Chr3:78546658-78571339 (-)
NOD/ShiLtJ ENSMUSG00190002566
 protein coding gene Chr3:76866014-76891077 (-)
NZO/HlLtJ ENSMUSG00225006007
 protein coding gene Chr3:81261915-81286979 (-)
PWK/PhJ ENSLUMG00010006280
 protein coding gene Chr3:76187723-76212226 (-)
SPRET/EiJ ENSMSPG00010016697
 protein coding gene Chr3:76920667-76945193 (-)
WSB/EiJ ENSIUOG00005002813
 protein coding gene Chr3:76777072-76802151 (-)



Homology
more
  • Human Ortholog
    ETFDH, electron transfer flavoprotein dehydrogenase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ETFDH, electron transfer flavoprotein dehydrogenase
  • Synonyms
    ETFQO, MADD
  • Links
    NCBI Gene ID: 2110
    UniProt: Q16134

  • Chr Location
    4q32.1; chr4:158671968-158710758 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human ETFDH associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 2 alleles in 2 genetic backgrounds
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    47
  • GO References
    16
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    763
  • Tissues
    144
  • cDNA Data
    102
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 66841 NCBI Gene Model | MGI Sequence Detail 24980 C57BL/6J ±  kb
    transcript NM_025794 RefSeq | MGI Sequence Detail 2281 ZRU/MplStud  
    polypeptide Q921G7 UniProt | EBI | MGI Sequence Detail 616 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000007217 electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial
      (term hierarchy)
    • EC
      1.5.5.1
    • InterPro Domains
      IPR017896 4Fe-4S ferredoxin-type, iron-sulphur binding domain
      IPR040156 Electron transfer flavoprotein-ubiquinone oxidoreductase
      IPR049398 ETF-QO/FixC, ubiquinone-binding
      IPR007859 ETF-QO/FixX, C-terminal domain
      IPR036188 FAD/NAD(P)-binding domain superfamily
    • GlyGen
      Q921G7 2 sites, 1 O-linked glycan (2 sites)
    Molecular
    Reagents
    less
    • All nucleic 106
      cDNA 105
      Primer pair 1
      Antibodies 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-33787, MGI:1914091, MGI:2139921
    References
    more
    • Summaries
      All 60
      Developmental Gene Expression 5
      Diseases 1
      Gene Ontology 16
      Phenotypes 15
    • Earliest
      J:32424 White RA, et al., Assignment of Etfdh, Etfb, and Etfa to chromosomes 3, 7, and 13: the mouse homologs of genes responsible for glutaric acidemia type II in human. Genomics. 1996 Apr 1;33(1):131-4
    • Latest
      J:367358 Ramalingam H, et al., An RNA transmethylation pathway governs kidney nephrogenic potential. Nat Commun. 2025 May 28;16(1):4930
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory