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Slc16a1 Gene Detail
Summary
  • Symbol
    Slc16a1
  • Name
    solute carrier family 16 (monocarboxylic acid transporters), member 1
  • Synonyms
    MCT1
  • Feature Type
    protein coding gene
  • IDs
    MGI:106013
    NCBI Gene: 20501
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:104545984-104565778 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 45.70 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    410 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_106013
 protein coding gene Chr3:104545980-104565778 (+)
129S1/SvImJ ENSMUSG00200041011
 protein coding gene Chr3:101152601-101172412 (+)
A/J ENSMUSG00195024457
 protein coding gene Chr3:101573485-101593277 (+)
AKR/J ENSMUSG00220038320
 protein coding gene Chr3:99931710-99951530 (+)
BALB/cJ ENSMUSG00180018209
 protein coding gene Chr3:101504546-101524343 (+)
C3H/HeJ ENSMUSG00175025778
 protein coding gene Chr3:101053876-101073665 (+)
C57BL/6NJ ENSMUSG00215019141
 protein coding gene Chr3:101816822-101836616 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025463
 protein coding gene Chr3:98692312-98711948 (+)
CAST/EiJ ENSTCUG00005019076
 protein coding gene Chr3:101775683-101795456 (+)
CBA/J ENSMUSG00210007508
 protein coding gene Chr3:101675923-101695712 (+)
DBA/2J ENSMUSG00185021866
 protein coding gene Chr3:102152930-102172724 (+)
FVB/NJ ENSMUSG00205027137
 protein coding gene Chr3:100737150-100756960 (+)
JF1/MsJ ENSUMUG00000037142
 protein coding gene Chr3:100893624-100913402 (+)
LP/J ENSMUSG00230014347
 protein coding gene Chr3:104080540-104100355 (+)
NOD/ShiLtJ ENSMUSG00190034545
 protein coding gene Chr3:102356543-102376337 (+)
NZO/HlLtJ ENSMUSG00225016338
 protein coding gene Chr3:106549111-106568906 (+)
PWK/PhJ ENSLUMG00010028037
 protein coding gene Chr3:100978231-100998008 (+)
SPRET/EiJ ENSMSPG00010030097
 protein coding gene Chr3:101161093-101178174 (+)
WSB/EiJ ENSIUOG00005004122
 protein coding gene Chr3:101699831-101719607 (+)



Homology
more
  • Human Ortholog
    SLC16A1, solute carrier family 16 member 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SLC16A1, solute carrier family 16 member 1
  • Synonyms
    HHF7, MCT, MCT1, MCT1D
  • Links
    NCBI Gene ID: 6566
    UniProt: P53985

  • Chr Location
    1p13.2; chr1:112911847-112957593 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human SLC16A1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    21 phenotypes from 1 allele in 1 genetic background
    1 images
    38 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes are non-viable, while heterozygous animals are resistant to diet-induced obesity.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    87
  • GO References
    18
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1181
  • Tissues
    190
  • cDNA Data
    208
  • Literature Summary
    56
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000032902 Ensembl Gene Model | MGI Sequence Detail 19795 C57BL/6J ±  kb
    transcript ENSMUST00000046212 Ensembl | MGI Sequence Detail 4426 Not Applicable  
    polypeptide ENSMUSP00000045216 Ensembl | MGI Sequence Detail 493 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 214
      cDNA 209
      Primer pair 4
      Other 1
      Antibodies 5

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-33695, MGI:2139849
    References
    more
    • Summaries
      All 144
      Developmental Gene Expression 56
      Diseases 1
      Gene Ontology 18
      Phenotypes 38
    • Earliest
      J:20825 Garcia CK, et al., cDNA cloning of the human monocarboxylate transporter 1 and chromosomal localization of the SLC16A1 locus to 1p13.2-p12. Genomics. 1994 Sep 15;23(2):500-3
    • Latest
      J:391320 Kokorudz C, et al., The imprinted Peg3 gene is a potent regulator of the DNA methylome in trophoblast cells. Stem Cell Reports. 2026 Aug 11;21(8):103021
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory