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Rps2 Gene Detail
Summary
  • Symbol
    Rps2
  • Name
    ribosomal protein S2
  • Synonyms
    Llrep3, Rps2
  • Feature Type
    protein coding gene
  • IDs
    MGI:105110
    NCBI Gene: 16898
  • Alliance
    genome feature page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:24939037-24940901 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 12.51 cM, cytoband A3.3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    184 from dbSNP Build 142
  • Strain Annotations
    23
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_105110
 protein coding gene Chr17:24937090-24940903 (+)
129S1/SvImJ ENSMUSG00200004201
 protein coding gene Chr6:50201646-50202582 (-)
129S1/SvImJ ENSMUSG00200049435
 protein coding gene Chr17:20384120-20387939 (+)
129S1/SvImJ ENSMUSG00200037519
 protein coding gene ChrX:35883196-35884156 (+)
A/J no annotation
AKR/J no annotation
BALB/cJ ENSMUSG00180037352
 protein coding gene Chr17:20682317-20686141 (+)
BALB/cJ ENSMUSG00180032405
 protein coding gene ChrX:36380162-36381110 (+)
C3H/HeJ ENSMUSG00175041141
 protein coding gene Chr17:20440676-20444500 (+)
C3H/HeJ ENSMUSG00175041157
 protein coding gene ChrX:39414781-39415728 (+)
C3H/HeJ ENSMUSG00175015142
 protein coding gene Chr6:49993889-49994825 (-)
C57BL/6NJ ENSMUSG00215050768
 protein coding gene Chr17:20445203-20449016 (+)
C57BL/6NJ ENSMUSG00215046986
 protein coding gene ChrX:36387865-36388825 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021201
 protein coding gene Chr17:20551908-20556240 (+)
CAST/EiJ no annotation
CBA/J ENSMUSG00210017772
 protein coding gene Chr6:50038209-50039145 (-)
CBA/J ENSMUSG00210036757
 protein coding gene ChrX:36638238-36639188 (+)
CBA/J ENSMUSG00210050330
 protein coding gene Chr17:20279505-20283329 (+)
DBA/2J no annotation
FVB/NJ ENSMUSG00205049727
 protein coding gene Chr2:21501354-21502279 (+)
FVB/NJ ENSMUSG00205042900
 protein coding gene Chr17:20742367-20746192 (+)
FVB/NJ ENSMUSG00205027633
 protein coding gene ChrX:34978446-34979392 (+)
JF1/MsJ no annotation
LP/J ENSMUSG00230027935
 protein coding gene ChrX:53886632-53887592 (+)
LP/J ENSMUSG00230012709
 protein coding gene Chr6:51698848-51699784 (-)
LP/J ENSMUSG00230054995
 protein coding gene Chr17:23888746-23893163 (+)
NOD/ShiLtJ ENSMUSG00190053738
 protein coding gene Chr17:20380049-20383868 (+)
NZO/HlLtJ no annotation
PWK/PhJ no annotation
SPRET/EiJ ENSMSPG00010048485
 protein coding gene Chr17:21183670-21186237 (+)
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    RPS2, ribosomal protein S2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RPS2, ribosomal protein S2
  • Synonyms
    LLREP3, S2, uS5
  • Links
    NCBI Gene ID: 6187
    UniProt: P15880

  • Chr Location
    16p13.3; chr16:1962050-1965510 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 1 allele in 1 genetic background
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for an allele with a point mutation die prior to weaning. Mice heterozygous for the allele exhibit reduced body fat, mild muscle weakness, and increased circulating creatine kinase level.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    36
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    604
  • Tissues
    4
  • cDNA Data
    25
  • Literature Summary
    8
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 16898 NCBI Gene Model | MGI Sequence Detail 1865 C57BL/6J ±  kb
    transcript NM_008503 RefSeq | MGI Sequence Detail 952 C57BL/6  
    polypeptide P25444 UniProt | EBI | MGI Sequence Detail 293 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 29
      Genomic 2
      cDNA 26
      Other 1

      Microarray probesets 17
    Other
    Accession IDs
    less
    MGD-MRK-32150
    References
    more
    • Summaries
      All 57
      Developmental Gene Expression 8
      Gene Ontology 10
      Phenotypes 8
    • Earliest
      J:19957 Heller DL, et al., A highly conserved mouse gene with a propensity to form pseudogenes in mammals. Mol Cell Biol. 1988 Jul;8(7):2797-803
    • Latest
      J:340704 Li J, et al., USP25 deficiency promotes T cell dysfunction and transplant acceptance via mitochondrial dynamics. Int Immunopharmacol. 2023 Feb 21;117:109917
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory